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Development of evaluation system for artificial organs from the viewpoints of clinical study, engineering, and statistics.

Research Project

Project/Area Number 15591491
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionSHIBAURA INSTITUTE OF TECHNOLOGY

Principal Investigator

FUJIMOTO Tetsuo  SHIBAURA INSTITUTE OF TECHNOLOGY, DEPARTMENT OF ENGINEERING, PROFESSOR, 工学部, 教授 (50267473)

Co-Investigator(Kenkyū-buntansha) UMEZU Mitsuo  WASEDA UNIVERSITY, GRADUATE SCHOOL OF SCIENCE AND ENGINEERING, PROFESSOR, 大学院・理工学研究科, 教授 (90132927)
OWASAKI Kiyotaka  WASEDA UNIVERSITY, GRADUATE SCHOOL OF SCIENCE AND ENGINEERING, ASSISTANT PROFESSOR, 大学院・理工学研究科, 講師 (20339691)
KAWAZOE Kohei  IWATE MEDICAL UNIVERSITY, SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (50075561)
北村 信夫  京都府立医科大学, 心臓血管外科, 教授 (70075513)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsartificial organ / circulatory simulator / arterial prosthetic graft / artificial heart valve / ventricular assist system / medical database / medical statistics / hemodynamics
Research Abstract

A circulatory simulator was developed in order to evaluate artificial organs such as ventricular assist systems, artificial heart valves, and arterial prosthetic grafts from the view point of hemodynamics. Some experiments were conducted to demonstrate characteristics of a rotary pump used for a right ventricular assist system and a newly designed aortofemoral prosthetic Y graft in the simulator. As a result, it was revealed that there was definitely an incremental increase in the branch diameter increasing the flow rate through the graft. In this study, a newly designed pressure transducer and an expandable tube for clinical application were devised. The former is enough small to be fixed into artificial organs in which the pressure can be measured. The latter was designed to expand the diameter of the tube as a tracheal tube and a cannula for left ventricular bypass. These inventions are lodging patent applications. In addition, a new database system was developed in order to analyze clinical data statistically. Clinical data including pulse wave velocity (PWV) were analyzed actually by the system and it was revealed the tendency that the risk of the death increases accompanied by increase in PWV as a result. It is supposed that the combination of the simulator and the database system will be useful to evaluate artificial organs from the viewpoints of clinical study, engineering, and statistics.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (51 results)

All 2006 2005 2004 2003 Other

All Journal Article (42 results) Book (2 results) Patent(Industrial Property Rights) (3 results) Publications (4 results)

  • [Journal Article] 医療機器産業における低競争力分野の原因検証研究(1)-薬事工業生産動態統計による国内市場の分析結果から-2006

    • Author(s)
      中野壮陛, 藤本哲男
    • Journal Title

      「医科器械学」に掲載決定 76・6

      Pages: 361-369

    • NAID

      110004749523

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 医療機器産業における低競争力分野の原因検証研究(1)〜薬事工業生産動態統計による国内市場の分析結果から〜2006

    • Author(s)
      中野壮陛, 藤本哲男
    • Journal Title

      医科器械学 (掲載決定)

    • NAID

      110004749523

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Numerical analysis for designing a new aortic cannula2005

    • Author(s)
      T.Fujimoto, et al.
    • Journal Title

      Int J Artif Organs 28-9

      Pages: 920-920

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of a newly-designed artificial myocardial assist device using biometal2005

    • Author(s)
      Y.Shiraishi, T.Fujimoto, et al.
    • Journal Title

      Int J Artif Organs 28・9

      Pages: 910-910

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 拡張管設計のための構造解析2005

    • Author(s)
      有賀睦, 藤本哲男, 他
    • Journal Title

      福祉工学シンポジウム2005講演論文集 05・44

      Pages: 95-98

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 脳動脈瘤の弾性体モデルによる力学的検討2005

    • Author(s)
      関根佑輔, 藤本哲男, 他
    • Journal Title

      福祉工学シンポジウム2005講演論文集 05・44

      Pages: 235-238

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantification of the Secondary Flow in a Radial Coupled Centrifugal Blood Pump Based on Particle Tracking Velocimetry2005

    • Author(s)
      Nobuo Watanabe, Tetsuo Fujimoto, et al.
    • Journal Title

      Artif Organs 29-1

      Pages: 26-35

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Basic flow characteristics of a pulsatile blood pump driven by two different drivers2005

    • Author(s)
      K.Ito, T.Fujimoto, et al.
    • Journal Title

      Abstract 8^<th> Japanese-Polish Seminar on New Engineering Method Supporting Human Life

      Pages: 51-51

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Numerical analysis for designing a new aortic cannula2005

    • Author(s)
      T.Fujimoto, M.Ariga, N.Kabei, M.Yoshida, M.Umezu
    • Journal Title

      Int J Artif Organs Vol.28-9

      Pages: 920-920

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Basic flow characteristics of a pulsatile blood pump driven by two different drivers2005

    • Author(s)
      K.Ito, T.Sudo, T.Shima, Y.Kouno, Y.Ohnishi, T.Tanaka, K.Iwasaki, T.Fujimoto, M.Umezu
    • Journal Title

      Abstract 8^<th> Japanese-Polish Seminar on New Engineering Method Supporting Human Life 51

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of a newly-designed artificial myocardial assist device using biometal2005

    • Author(s)
      Y.Shiraishi, T.Yambe, K.Sekine, N.Masumoto, J.Nagatoshi, S.Itoh, E.Okamoto, M.Higa, T Fujimoto, et al.
    • Journal Title

      Int J Artif Organs Vol.28-9

      Pages: 910-910

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantification of the Secondary Flow in a Radial Coupled Centrifugal Blood Pump Based on Particle Tracking Velocimetry2005

    • Author(s)
      Nobuo Watanabe, Takaya Masuda, Tomoya Iida, Hiroyuki Kataoka, Tetsuo Fujimoto, Setsuo Takatani
    • Journal Title

      Artif Organs Vol.29-1

      Pages: 26-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structure analysis for expanding tube design2005

    • Author(s)
      Mutsumi Aruga, Tetsuo Fujimoto, et al.
    • Journal Title

      Proceedings of the Welfare Engineering Symposium 2005 No.05-44

      Pages: 95-98

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Study on cerebral aneurysm in elastic simulation model2005

    • Author(s)
      Yusuke Sekine, Tetsuo Fujimoto, et al.
    • Journal Title

      Proceedings of the Welfare Engineering Symposium 2005 No.05-44

      Pages: 235-238

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Numerical analysis for designing a new aortic cannlula2005

    • Author(s)
      T.Fujimoto, et al.
    • Journal Title

      Int J Artif Organs 28-9

      Pages: 920-920

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Development of a newly-designed artificial myocardial assist device using biometal2005

    • Author(s)
      Y.Shiraishi, T.Fujimoto, et al.
    • Journal Title

      Int J Artif Organs 28-9

      Pages: 910-910

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 拡張管設計のための構造解析2005

    • Author(s)
      有賀睦, 藤本哲男, 他
    • Journal Title

      福祉工学シンポジウム2005講演論文集 05-44

      Pages: 95-98

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 脳動脈瘤の弾性体モデルによる力学的検討2005

    • Author(s)
      関根佑輔, 藤本哲男, 他
    • Journal Title

      福祉工学シンポジウム2005講演論文集 05-44

      Pages: 235-238

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of the elastic conditions around a stentless valvular bioprosthesis on opening behavior2004

    • Author(s)
      Tetsuo Fujimoto, et al.
    • Journal Title

      J Artif Organs 7・3

      Pages: 133-136

    • NAID

      10014228309

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A newly designed cannula for left ventricular bypass2004

    • Author(s)
      Tetsuo Fujimoto, et al.
    • Journal Title

      Int J Artif Organs 27-7

      Pages: 624-624

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Computational fluid dynamics (CFD) analysis of flow field inside a centrifugal blood pump2004

    • Author(s)
      Nobuo Watanabe, Tetsuo Fujimoto, et al.
    • Journal Title

      Reports of the institute of biomaterials and bioengineering Tokyo medical and dental university 37

      Pages: 68-74

    • NAID

      40006167023

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 脳動脈瘤の力学的解析用モデルの開発2004

    • Author(s)
      新井邦明, 藤本哲男, 他
    • Journal Title

      福祉工学シンポジウム2004講演論文集(日本機械学会) No.04-42

      Pages: 127-129

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] オシロメトリック信号の解析を目的とした血圧-空気圧の計算モデルの開発2004

    • Author(s)
      臺寛史, 藤本哲男, 他
    • Journal Title

      福祉工学シンポジウム2004講演論文集(日本機械学会) No.04-42

      Pages: 131-134

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of the elastic conditions around a stentless valvular bioprosthesis on opening behavior2004

    • Author(s)
      Tetsuo Fujimoto, Daisuke Kawaguchi, Yasuyuki Shiraishi, Kiyotaka Iwasaki, Makoto Arita, Takashi Tanaka, Mitsuo Umezu
    • Journal Title

      J Artif Organs Vol.7-3

      Pages: 133-136

    • NAID

      10014228309

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Novel Cell Sheet Manipulator to Fabricate Three-Dimensional Tissue and to Quantify Cell Sheet Adhesiveness2004

    • Author(s)
      Sato, K, Shimizu, T, Isoi, Y, Yamato, M, Kikuchi, A, Fujimoto, T, Okano, T
    • Journal Title

      Transactions of 7th World Biomaterials Congress - 2004 1849

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A newly designed cannula for left ventricular bypass2004

    • Author(s)
      T.Fujimoto, A.Yonekawa, M.Aruga, N.Kabei, M.Yoshida, M.Umez
    • Journal Title

      Int J Artif Organs Vol.27-7

      Pages: 624-624

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Computational fluid dynamics (CFD) analysis of flow field inside a centrifugal blood pump2004

    • Author(s)
      Nobuo Watanabe, Tetsuo Fujimoto, Helmut Reul, Setsuo Takatani
    • Journal Title

      Reports of the institute of biomaterials and bioengineering Tokyo medical and dental university Vol.37

      Pages: 68-74

    • NAID

      40006167023

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of mechanical model with simulated cerebral aneurysm2004

    • Author(s)
      Kuniaki Arai, Tetsuo Fujimoto, et al.
    • Journal Title

      Proceedings of the Welfare Engineering Symposium 2004 No.04-42

      Pages: 127-129

    • NAID

      110004078960

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of a mechanical oscillation model for analyzing oscillometric signals2004

    • Author(s)
      Hiroshi Dai, Tetsuo Fujimoto, et al.
    • Journal Title

      Proceedings of the Welfare Engineering Symposium 2004 No.04-42

      Pages: 131-134

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of the elastic conditions around a stentless valvular bioprosthesis on opening behavior2004

    • Author(s)
      Tetsuo Fujimoto, et al.
    • Journal Title

      J Artif Organs 7-3

      Pages: 133-136

    • NAID

      10014228309

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A newly designed cannula for left ventricular bypass2004

    • Author(s)
      T.Fujimoto, et al.
    • Journal Title

      Int J Artif Organs 27-7

      Pages: 624-624

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 脳動脈瘤の力学的解析用モデルの開2004

    • Author(s)
      新井邦明, 藤本哲男, 他
    • Journal Title

      福祉工学シンポジウム2004講演論文集 04-42

      Pages: 4-42

    • Related Report
      2004 Annual Research Report
  • [Journal Article] オシロメトリック信号の解析を目的とした血圧-空気圧の計算モデルの開発 第2報2004

    • Author(s)
      臺寛史, 藤本哲男, 他
    • Journal Title

      福祉工学シンポジウム2004講演論文集 04-42

      Pages: 131-134

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Evaluation of freestyle bioprosthesis behavior in mechanical circulatory system2003

    • Author(s)
      Tetsuo Fujimoto, et al.
    • Journal Title

      Biocybernetics and Biomedical Engineering 23-2

      Pages: 51-55

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of bifurcation on pressure loss in aortofemoral prosthetic Y grafts2003

    • Author(s)
      Tetsuo Fujimoto, et al.
    • Journal Title

      Int J Artif Organs 26-7

      Pages: 629-629

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dynamic and static evaluation of two types of annuloplasty rings at mitral position using a mock circuit with fresh porcine valve2003

    • Author(s)
      M.Umezu, Tetsuo Fujimoto, et al.
    • Journal Title

      Int J Artif Organs 26-7

      Pages: 659-659

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] オシロメトリック信号の解析を目的とした血圧-空気圧の計算モデルの開発2003

    • Author(s)
      岡本京子, 藤本哲男, 他
    • Journal Title

      日本機械学会第3回福祉工学シンポジウム講演論文集 No.03-28

      Pages: 233-236

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evaluation of freestyle bioprosthesis behavior in mechanical circulatory system2003

    • Author(s)
      T.Fujimoto, D.Kawaguchi, Y.Shiraishi, K.Iwasaki, M.Arita, M.Umezu
    • Journal Title

      Biocybernetics and Biomedical Engineering Vol.23-2

      Pages: 51-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of bifurcation on pressure loss in aortofemoral prosthetic Y grafts2003

    • Author(s)
      T.Fujimoto, H.Ohashi, K.Arai, K.Okamoto, H.Iwamura, Y.Shiraishi, M.Umezu
    • Journal Title

      Int J Artif Organs Vol.26-7

      Pages: 629-629

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dynamic and static evaluation of two types of annuloplasty rings at mitral position using a mock circuit with fresh porcine valve2003

    • Author(s)
      M.Umezu, K.Iwasaki, M.Arita, M.Okuda, H.Doi, T.Yagi, H.Kasegawa, T.Fujimoto
    • Journal Title

      Int J Artif Organs Vol.26-7

      Pages: 659-659

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of a mechanical oscillation model for analyzing oscillometric signals2003

    • Author(s)
      Kyoko Okamoto, Tetsuo Fujimoto, et al.
    • Journal Title

      Proceedings of the 3rd JSME Sumposium on Welfare Engineering No.03-28

      Pages: 233-236

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Research of the principal cause of Japan being a lesser competitive power in the field of medical devices industry

    • Author(s)
      Shohei Nakamo, Tetsuo Fujimoto, et al.
    • Journal Title

      Japanese society of medical instrumentation 76-6

      Pages: 361-369

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 人工臓器で幸せですか?2005

    • Author(s)
      梅津光生, 藤本哲男, 他
    • Total Pages
      144
    • Publisher
      コロナ社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Book] Transactions of 7th World Biomaterials Congress - 20042004

    • Author(s)
      Sato, K, Fujimoto, T, et al.
    • Total Pages
      1849
    • Publisher
      Novel Cell Sheet Manipulator to Fabricate Three-Dimensional Tissue and to Quantify Cell Sheet Adhesiveness
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] アレイ型接触圧センサ2005

    • Inventor(s)
      藤本哲男, 他2名
    • Industrial Property Rights Holder
      株式会社ユネクス佐々木秀人
    • Industrial Property Number
      2005-030232
    • Filing Date
      2005-02-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] アレイ型接触圧センサ2005

    • Inventor(s)
      竹花 良人, 藤本 哲男, 佐々木 秀人
    • Industrial Property Rights Holder
      株式会社ユネクス, 佐々木 秀人
    • Industrial Property Number
      2005-030232
    • Filing Date
      2005-02-07
    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] 挿入管2004

    • Inventor(s)
      藤本哲男, 他2名
    • Industrial Property Rights Holder
      学校法人芝浦工業大学
    • Industrial Property Number
      2004-071761
    • Filing Date
      2004-03-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] T.Fujimoto: "Evaluation of freestyle bioprosthesis behavior in mechanical circulatory system"Biocybernetics and Biomedical Engineering. 23・2. 51-55 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nobuo Watanabe: "Computational fluid dynamics(CFD) analysis of flow field inside a center fugal blood pump"Reports of the institute of biomaterials and bioengineering, Tokyo medical and dental Univ.. 37. 68-74 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tetsuo Fujimoto: "Effect of elastic condition around a stentress valvular biopresthesis on opening behavior"Journal of Artificial Organs. 掲載予定.

    • Related Report
      2003 Annual Research Report
  • [Publications] 岡本京子: "オシロメトリック信号の解析を目的とした血圧-空気圧の計算モデルの開発"日本機械学会第3回福祉工学シンポジウム講演論文集. No.03-28. 233-236 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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