| Project/Area Number |
15591520
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | KYOTO UNIVERSITY |
|---|
Principal Investigator |
IKEDA Akio Kyoto University, Graduate School of Medicine, Lecturer, 医学研究科, 講師 (90212761)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHIGASHI Yoshitaka Kyoto University, Graduate School of Human and Environmental Studies, Professor, 人間・環境学研究科, 教授 (90169053)
MIYAMOTO Susumu National Cardiovascular Center, Head of Department of Neurosurgery, 脳神経外科, 部長 (70239440)
FUKUYAMA Hidenao Kyoto University, Graduate School of Medicine, Professor, 医学研究科, 教授 (90181297)
MIKUNI Nobuhiro Kyoto University, Graduate School of Medicine, Assistant Professor, 医学研究科, 助手 (60314217)
|
|---|
| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
|---|
| Keywords | Language area / Basal temporal language area / Event-related potentials / Chronic implantation of subdural electrode / functional cortical mapping / Wada test |
|---|
| Research Abstract |
We investigated the function and the localization of the left basal temporal language area (LBTA) in patients with intractable left mesial temporal lobe epilepsy as follows.
(1) Functions of LBTA by means of electric cortical stimulation
Reading, writing auditory comprehension were investigated while LBTA was stimulated. It was concluded that (a) LBTA was involved in visual- and auditory-language processing, at least independently, each dealing with morphological/semantic and phonological information, respectively, (b) kanji words and kana non-words were independently processed in the LBRA, and (c) cognitive processing of kanji words and object/picture partly shared the same process in the LBTA.
(2) Event-related potential study in the LBTA for the language function
Event-related potentials were recorded from the patients with intractable left mesial temporal lobe epilepsy by means of subdural electrodes implanted on the left basal temporal cortex and depth electrodes within the hippocampu
… More
s, where the patients were requested to read visually presented kanji/ kana words and to name the presented picture/objects silently. As the result, N200 potentials were recognized in response to the silent reading at or very close to LBTA.
(3) Neuropsychological analysis in association with left selective hippocampectomy
Neuropsychological analysis such as Wechsler Memory Scale-Revised was investigated in patients with intractable left mesial temporal lobe epilepsy after left selective hippocampectomy. After surgery, verbal memory score became higher as compared with before surgery. It could suggest that LBTA could play the significant role in verbal memory function, probably as combined with hippocampus.
(4)Clinical methods define the language dominancy in the cerebral hemispheres
Wada test with amobarbital is one of the most reliable methods to define the language and memory dominancies in the cerebral hemispheres. We demonstrated that clinically propofol was as useful as amobarbital in Wada test for patients before epilepsy surgery and lesion surgery. Less
|
