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Prevention of neurodegeneration after head injury by activated maicroglia with antisense method

Research Project

Project/Area Number 15591537
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNagoya City University

Principal Investigator

AIHARA Noritaka  Nagoya City University, Garduae School of Medical Sciences, Research Associate, 大学院・医学研究科, 講師 (00264739)

Co-Investigator(Kenkyū-buntansha) YAMADA Kazuo  Nagoya City University, Garduae School of Medical Sciences, Professor, 大学院・医学研究科, 教授 (90150341)
MASE Mitsuhito  Nagoya City University, Garduae School of Medical Sciences, Associate Professor, 大学院・医学研究科, 助教授 (60238920)
KATANO Hiroyuki  Nagoya City University, Garduae School of Medical Sciences, Associate Professor, 大学院・医学研究科, 助教授 (30295612)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsactivated microglia / traumatic brain injury / Brain-deraived neurotrophic factor / myelencephalon-specific protease / hjigher cortical dysfunction / MAPK / degenerarting neuron / CMRO2 / 頭部外傷 / 神経変性
Research Abstract

In order to clarify after the pathophysiological of cognitive impairment after traumatic brain injury. Fifty-two patients with mild traumatic brain injury were devided into three groups based on magneteic resonance images (MRI). Findings. Regional cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2) were measured by PET. Higher cortical dysfunction was evaluated using Wechsler Adult Intelligence Scale-Revised (WAIS R). We concluded that the severity of higher cortical dysfmction is correlated with decrease of CMR02. To elucidated temporal pattern of histological changes in diffuse brain injury, we developed the rat diffuse brain injurt model We examined the histological changes after difi'use brain injury using silver impregnation method for selcive demonstration of collapsed neurons. Quantitative evaluation revealed that the number of dark axons at the cerebral peduncles invreased during the experimental peropd. We revealed that axon progressively degenerate after diffse brain injury in rat model. Activated microglia infiltrates in degenerated neuron. Activated microglia were evaluated phosphorylation of p38 mitogen-activated protein kinase (MAPK). Activated microglia produce Brain-deraived neurotrophic factor (BDNF), but the amount of BDNF is insufficient for the rescue of degenerarting neuron. We also examined the expression of myelencephalon-specific protease (MSP) after rat brain injury model. The gene of MSP is a member of the kallikrein gene fatnihy and in rats is expressed mainly in the central nervous system. MSP was expressed mainly in oligodendrocytes. We suggest that the expression of MSP may be related to turnover of myelin-associated proteins and extracelluar matrix proteins after brain injury. The regulation of active MSP may be important in the physiological or pathological changes involved in remyelination or demyelination.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (12 results)

All 2005 2004 2003

All Journal Article (12 results)

  • [Journal Article] Expression of Myelencephalon-Specific Protease after cryogentic leasioning of the rat parietal cortex2005

    • Author(s)
      Y.Oka, et al.
    • Journal Title

      Jounal of Neurotrauma 22

      Pages: 501-510

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cerebral blood flow and metabolism in patients with cognitive impairments after minor traumatic brain injury : PET study in chronic state2004

    • Author(s)
      M.Mase, et al.
    • Journal Title

      International Congress Series 1259

      Pages: 365-369

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Upregulation of aquaporin-1 in experimental hydrocephalus ameliorated with shunting2004

    • Author(s)
      K.Isomura, et al.
    • Journal Title

      Nagoya Medical Journal 46・4

      Pages: 181-194

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Microcirculation と遺伝子発現2004

    • Author(s)
      片野 広之ほか
    • Journal Title

      CLINICAL NEUROSCIENCE 22・4

      Pages: 399-402

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of myelospecific protease intransient meddle cerebral artery occusion model of rat2004

    • Author(s)
      Asushi Ueda, et al.
    • Journal Title

      Molecular Brain Research 126

      Pages: 129-136

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cerebral blood flow and metabolism in patients with cognitiveimpairments after minor traumatic brain injury : PET study in chronic state2004

    • Author(s)
      M.Mase, et al.
    • Journal Title

      International Congress Series 1259

      Pages: 365-369

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Upregulation of aquaporin-1 in experimental hydrocephalus ameliorated with shunting2004

    • Author(s)
      K.Isomura, et al.
    • Journal Title

      Nagoya Medical Journal 46.4

      Pages: 181-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Microcirculationと遺伝子発現2004

    • Author(s)
      片野 広之ほか
    • Journal Title

      CLINICAL NEUROSCIENCE 22・4

      Pages: 399-402

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression of myelospecific protease intransient meddle cerebral artery occusion model of rat brain2003

    • Author(s)
      A.Ueda, et al.
    • Journal Title

      Molecular Brain Research 126

      Pages: 129-136

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Neurodegeneratio accompanied with macrophage/microglia infiltration after intrastriatal hemorrhage n of substantia nigra2003

    • Author(s)
      N.Imamura, et al.
    • Journal Title

      Neuroscience Research 46

      Pages: 289-293

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Neurodegeneration of substantia nigra accompanied with macrophage/microglia infiltration after intrastriatal hemorrhage2003

    • Author(s)
      N.Imamura, et al.
    • Journal Title

      Neuroscience Research 46

      Pages: 289-293

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Lipocalin-type prostaglandin D synthase (beta-trace) in cerebrospinal fluid : a useful marker for the diagnosis of normal pressure hydrocephalus2003

    • Author(s)
      M.Mase, et al.
    • Journal Title

      Neuroscience Research 47

      Pages: 455-459

    • NAID

      10016209493

    • Related Report
      2004 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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