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Functional analysis of the neuronal network in patients with functional disorder of basal ganglia using non-invasive neurotransmitter imaging

Research Project

Project/Area Number 15591538
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

SASAJIMA Hiroyasu  Kyoto Prefectural University of Medicine, School of Medicine, Assistant professor, 医学研究科, 講師 (80196188)

Co-Investigator(Kenkyū-buntansha) MINEURA Katsuyoshi  Kyoto Prefectural University of Medicine, School of Medicine, Professor, 医学研究科, 教授 (70134103)
IMAHORI Yoshio  Kyoto Prefectural University of Medicine, School of Medicine, Associate professor, 医学研究科, 助教授 (80191899)
INOUE Yasuo  Kyoto Prefectural University of Medicine, School of Medicine, Assistant professor, 医学研究科, 助手 (60363975)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2003: ¥3,100,000 (Direct Cost: ¥3,100,000)
Keywordsbasal ganglia / PET / ^<18>F-fluorodopa / ^<11>C-diacylglycerol / brain tumor / cerebral infarction / network plasticity / neurotransmitter / パーキンソン病
Research Abstract

The basal ganglia are undoubtedly among the most complex and least understood structures in the mammalian forebrain. In this study, we evaluated phosphoinositide turnover in the cerebrum and dopamine metabolism in the basal ganglia using ^<11>C-diacylglycerol-positron emission computed tomography(PET) and ^<18>F-fluorodopa-PET in patients with functional disorder of basal ganglia before and after treatment.
^<11>C-diacylglycerol-PET of Parkinson's disease showed acceleration of the phosphoinositide turnover of the bilateral striatum and functional supression of the ipsilateral thalamus. These results indicate the superiority of the indirect pathway through subthalamic nucleus in patients with Parkinson's disease.
^<11>C-diacylglycerol-PET studies in patients with cerebral infarction revealed hyperaccumlation in the prefrontal area in the subacute stage of cerebral infarction. The hyperaccumlation of ^<11>C-diacylglycerol in the prefrontal area in the subacute stage may indicate network plasticity in the cerebrum.
Serial ^<18>F-fluorodopa-PET studies revealed hyperfunction of the presynaptic dopaminergic cells of the bilateral striatum in bobble-head doll syndrome. The suppression of output systems caused by hyperfunction of the presynaptic dopaminergic cells may play an important role of the occurrence of bobble-head doll movement.
In the diffuse infiltrating tumor of the basal ganglia, ^<18>F-fluorodopa-PET study revealed that the presynaptic dopaminergic cells of the bilateral striatum were consistent within the tumor. In the expansive tumor such as metastatic tumors, ^<18>F-fluorodopa-PET showed accumulation of ^<18>F-fluorodopa in the striatum around the tumor. These results indicate that ^<18>F-fluorodopa-PET studies contribute to a qualitative diagnosis of the tumor in the basal ganglia.
These PET data will be practical use for in vivo analysis of human basal ganglia and direct prediction of the network plasticity in the cerebrum.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (17 results)

All 2004 2003 Other

All Journal Article (12 results) Book (1 results) Publications (4 results)

  • [Journal Article] 運動の高次脳機能イメージング2004

    • Author(s)
      峯浦一喜, 笹島浩泰, 今堀良夫
    • Journal Title

      臨床スポーツ医学 21(9)

      Pages: 1047-1055

    • NAID

      10013670502

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 不安障害におけるPET所見と臨床心理学的評価2004

    • Author(s)
      今堀良夫, 前川晶代, 大和田敬, 笹島浩泰, 峯浦一喜
    • Journal Title

      Progress in medicine 24(11)

      Pages: 3016-3019

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 高齢者眼窩内腫瘍の手術2004

    • Author(s)
      大和田敬, 笹島浩泰, 立澤和典, 峯浦一喜
    • Journal Title

      Geriatric Neurosurgery 16

      Pages: 97-100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Functional brain mapping image in physical exercise.2004

    • Author(s)
      Mineura K, Sasajima H, Imahori Y.
    • Journal Title

      The Journal of Clinical Sports Medicine 21(9)

      Pages: 1407-1055

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] FDG-PET mapping of regional brain activity in patients with panic disorder.2004

    • Author(s)
      Imahori Y, Maekawa A, Owada K, Sasajima H, Mineura K.
    • Journal Title

      Progress in medicine 24(11)

      Pages: 3016-3019

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Surgical treatment of intraorbital tumors using a transcranial orbitofrontal approach in the elderly.2004

    • Author(s)
      Owada K, Sasajima H, Tatsuzawa K, Mineura K.
    • Journal Title

      Geriatric Neurosurgery 16

      Pages: 97-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Brain fiber tracking with clinically feasible diffusion-tensor MR imaging. Initial experience2003

    • Author(s)
      Yamada K, Kizu O, Mori S, Ito H, Nakamura H, Sasajima H, et al.
    • Journal Title

      Radiology 227(1)

      Pages: 295-301

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 分子画像診断.放射性トレーサーの現状と今後の展開2003

    • Author(s)
      今堀良夫, 大和田敬, 立澤和典, 笹島浩泰, 峯浦一喜
    • Journal Title

      分子脳血管病 2(2)

      Pages: 149-156

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] FDG-PETとmethionine-PET2003

    • Author(s)
      峯浦一喜, 笹島浩泰, 大和田敬, 今堀良夫
    • Journal Title

      Clinical Neuroscience 21(5)

      Pages: 537-538

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Brain fiber tracking with clinically feasible diffusion-tensor MR imaging. Initial experience.2003

    • Author(s)
      Yamada K, Kizu O, Mori S, Ito H, Nakamura H, Sasajima H, et al.
    • Journal Title

      Radiology 227(1)

      Pages: 295-301

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Current status and future development of radioactive tracer.2003

    • Author(s)
      Imahori Y, Owasa K, tatsuzawa K, Sasajima H, Mineura K
    • Journal Title

      Molecular Cerebrovascular Medicine 2(2)

      Pages: 149-156

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] FDG-PET and methionine-PET.2003

    • Author(s)
      Mineura K, Sasajima H, Owada K, Imahori Y.
    • Journal Title

      Clinical Neuroscience 21(5)

      Pages: 537-538

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] QOL向上を目指した癌の外来化学療法マニュアル.脳腫瘍(垣添忠生(監修))2003

    • Author(s)
      峯浦一喜, 高橋義信, 笹島浩泰, 笹嶋寿郎
    • Total Pages
      335
    • Publisher
      メディカルレビュー社,大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Yamada K, Kizu O, Mori S, Ito H, Nakamura H, Sasajima H, et al.: "Brain fiber tracking with clinically feasible diffusion-tensor MR imaging. Initial experience"Radiology. 227(1). 295-301 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 今堀良夫, 大和田敬, 立澤和典, 笹島浩泰, 峯浦一喜: "分子画像診断.放射性トレーサーの現状と今後の展開"分子脳血管病. 2(2). 149-156 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 峯浦一喜, 笹島浩泰, 大和田敬, 今堀良夫: "FDG-PETとmethionine-PET"Clinical Neuroscience. 21(5). 537-538 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 峯浦一喜, 高橋義信, 笹島浩泰, 笹嶋寿郎: "垣添忠生(監修):QOL向上を目指した癌の外来化学療法マニュアル.脳腫瘍"メディカルレビュー社,大阪. 335 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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