| Project/Area Number |
15591541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
OGASAWARA Kuniaki Iwate Medical University, Department of Neurosurgery, Associate professor, 医学部, 助教授 (00305989)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Akira Iwate Medical University, Department of Neurosurgery, Professor, 医学部, 教授 (10204067)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2003: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Hemodynamic cerebral ischemia / Acetazolamide / Positron emission tomography / Cerebral oxygen extraction fraction / position emission tomography |
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| Research Abstract |
The aim of this study was to clarify relationship between sequential changes of cerebral blood flow (CBF) after acetazolamide loading and cerebral oxygen metabolism (CMRO_2). The subjects consisted of 30 patients with severe stenosis or occlusion of the internal carotid or middle cerebral or vertebro-basilar artery. Regional CBF was measured at the resting state and at 6, 16 and 30 minutes after the intravenous administration of 1 g acetazolamide using the [^<15>O]H_2 O bolus-injection method and positron emission tomography. Prior to CBF study, regional cerebral oxygen extraction fraction (OEF) was measured using the [^<15>O]O_2 inhalation method. Regional CMRO_2 was calculated based on CBF and OEF. Good response type (CBF increase rate more than 20% at 6 minutes after acetazolamide loading), paradoxical response type (decrease of CBF at 6 minutes after acetazolamide loading) and poor response type (CBF increase rate less than 20% at 6 minutes after acetazolamide loading) were identified in 39, 11 and 10 areas, respectively. Areas with good response type showed normal OEF and normal CMRO_2. Areas with paradoxical response type showed increased OEF. Areas with poor response type showed normal GEF and decreased CMRO_2. In view of these findings, the author concludes that sequential measurement of cerebral blood flow (CBF) after acetazolamide loading enables to know regional cerebral oxygen metabolic state in patients with hemodynamic ischemia, and CBF should be measured early after the administration of acetazolamide to accurately detect misery perfusion.
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