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Radiation-induced oligodendroglial apoptosis and demyelination in the brain

Research Project

Project/Area Number 15591548
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKyorin University

Principal Investigator

KURITA Hiroki  Kyorin University, School of Medicine, Assistant Professor, 医学部, 講師 (70262003)

Co-Investigator(Kenkyū-buntansha) SHIOKAWA Yoshiaki  Kyorin University, School of Medicine, Professor, 医学部, 教授 (20245450)
坪川 民治  杏林大学, 医学部, 助手 (30360100)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsradiosurgery / oligodendroglia / apoptosis / demyelination / radiation necrosis / p53 knockout mouse / oligodendroglia / Radiosurgery / oilgodendrocyte / rasiation necrosis / aminosteroid / optic chiasm / Radiation / Apoptosis / Optic chiasm
Research Abstract

The adverse effect of radiosurgery (single, high-dose irradiation) to the central nervous system remains to be elucidated.
The purpose of this study was to characterize the apoptotic death of oligodendrocyte immediately after the irradiation, and to investigate the relationship between the acute cell loss and delayed demyelinating encephalopathy or radiation necrosis of the brain.
The extent of acute oligodendroglial cell loss several hours after the radiation was well correlated with the extent of delayed encephalopathy in rat radiosurgery model. The radioprotectant drugs, such as aminosteroids and corticosteroids did not block the acute cell death.
Single high-dose irradiation also resulted in vasculopathy of the microvessels of the brain, which caused cyst formation or repetitive bleeding within the irradiated brain. Immunohistopathological investigation confirmed the destruction of tight gap junction of endothelium and exudation to the surrounding tissues.
In conclusion, acute oligodendroglial loss and endothelial damage play a significant role for delayed radiation necrosis in the central nervous system

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (28 results)

All 2006 2005 2004 2003

All Journal Article (28 results)

  • [Journal Article] Management and outcome of hemorrhage after Gamma Knife surgery for arteriovenous malformations of the brain2006

    • Author(s)
      Maruyama K, Shin M, Kurita H, et al.
    • Journal Title

      Journal of Neurosurgery 105

      Pages: 52-57

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Management and outcome of hemorrhage after Gamma Knife surgery for arteriovenous malformations of the brain.2006

    • Author(s)
      Maruyama K, Shin M, Kurita H, et al.
    • Journal Title

      Journal of Neurosurgery 105

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Radiation induced apoptosis of oligodendrocytes in the rat optic chiasm2005

    • Author(s)
      Nagayama K, Kurita H, Nakamura M, et al.
    • Journal Title

      Neurological Research 27

      Pages: 346-350

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gamma knife radiosurgery for hemangioblastomas.2005

    • Author(s)
      Tago M, Terahara A, Kurita H, et al.
    • Journal Title

      Journal of Neurosurgery 102

      Pages: 171-174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gamma knife radiosurgery for arteriovenous malformations involving the corpus callosum.2005

    • Author(s)
      Maruyama K, Shin M, Kurita H, et al.
    • Journal Title

      Journal of Neurosurgery 102

      Pages: 49-52

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The risk of hemorrhage from cerebral arteriovenous malformations treated with radiosurgery.2005

    • Author(s)
      Maruyama K, Kawahara N, Kurita H, et al.
    • Journal Title

      New England Journal of Medicine 352

      Pages: 146-153

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Radiation induced apoptosis of oligodendrocytes in the rat optic chiasm.2005

    • Author(s)
      Nagayama K, Kurita H, Nakamura M, et al.
    • Journal Title

      Neurological Research 27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] G amma knife radiosurgery for hemangioblastomas.2005

    • Author(s)
      Tago M, Terahara A, Kurita H, et al.
    • Journal Title

      Journal of Neurosurgery 102

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Radiation-induced apoptosis of oligodendrocytes in the rat optic chiasm.2005

    • Author(s)
      Nagayama K, Kurita H, et al.
    • Journal Title

      Neurological Research 27

      Pages: 346-350

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Radiation-induced apoptosis of oligodendroglia in the rat optic chiasm2005

    • Author(s)
      Nagayama K, Kurita H, et al.
    • Journal Title

      Neurological Research (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Morphologic changes in neo-intimal proliferation in an experimental aneurysm after coil embolization.2004

    • Author(s)
      Hino K, Konishi Y, Kurita H, et al.
    • Journal Title

      Neuroradiology 46

      Pages: 996-1005

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] High plasma concentration of brain natriuretic peptide in patients with ruptured Acom aneurysms.2004

    • Author(s)
      Tsubokawa T, Shiokawa Y, Kurita H, et al.
    • Journal Title

      Neurological Research 26

      Pages: 893-896

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Proposed treatment strategy for cavernous sinus meningiomas : a prospective study2004

    • Author(s)
      Maruyama K, Shin M, Kurita H, et al.
    • Journal Title

      Neurosurgery 55

      Pages: 1068-1075

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Schwannoma involving the sphenoid sinus2004

    • Author(s)
      Tanaka C, Kurita H, Shiokawa Y, et al.
    • Journal Title

      Acta Neurochirurugica 146

      Pages: 1159-1160

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Histopathological findings of symptomatic degenerate AVMs after radiosurgery2004

    • Author(s)
      Tanaka C, Kurita H, Nakamura M, et al.
    • Journal Title

      Stereotactic Radiotherapy 8

      Pages: 27-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Defecation-induced vertigo2004

    • Author(s)
      Kurita H, Nitta Y, Nakamura M, et al.
    • Journal Title

      Archives of Neurology 61

      Pages: 1137-1138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Analysis of nidus obliteration rates after gamma knife surgery for AVMs based on long-term follow-up data.2004

    • Author(s)
      Shin M, Maruyama K, Kurita H, et al.
    • Journal Title

      Journal of Neurosurgery 101

      Pages: 18-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Meningiomatosis in a survivor of Hiroshima2004

    • Author(s)
      Hino K, Kurita H, Shiokawa Y
    • Journal Title

      Journal of Neurology 251

      Pages: 99-99

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stereotactic radiosurgery in current neurosurgical practice2004

    • Author(s)
      Kurita H
    • Journal Title

      Teishin-Igaku 56

      Pages: 5-25

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Morphologic changes in neo-intimal proliferation in an experimental aneurysm after coil embolization : effect of factor XIII administration2004

    • Author(s)
      Hino K, Konishi Y, Kurita H, et al.
    • Journal Title

      Neuroradiology 46

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] High plasma concentration of brain natriuretic peptide in patients with ruptured Acorn aneurysms.2004

    • Author(s)
      Tsubokawa T, Shiokawa Y, Kurita H, et al.
    • Journal Title

      Neurological Research 26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Histopathological findings of symptomatic degenerate AVMs after radiosurgery.2004

    • Author(s)
      Tanaka C, Kurita H, Nakamura M, et al.
    • Journal Title

      Stereotactic Radiotherapy 8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Meningiomatosis in a survivor of Hiroshima.2004

    • Author(s)
      Hino K, Kurita H, Shiokawa Y
    • Journal Title

      Journal of Neurology 251

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stereotactic radiosurgery in current neurosurgical practice.2004

    • Author(s)
      Kurita H
    • Journal Title

      Teishin-Igaku 56

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Adverse effects of radiosurgery for cerebral arteriovenous malformations2003

    • Author(s)
      Maruyama K, Shin M, Kurita H, et al.
    • Journal Title

      Stereotactic Radiotherapy 7

      Pages: 33-37

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Salvage surgery for symptomatic degenerate AVMs after radiosurgery2003

    • Author(s)
      Kurita H, Nakamura M, Shiokawa Y, et al.
    • Journal Title

      Stereotactic Radiotherapy 7

      Pages: 39-43

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Adverse effects of radiosurgery for cerebral arteriovenous malformations.2003

    • Author(s)
      Maruyama K, Shin M, Kurita H, et al.
    • Journal Title

      Stereotactic Radiotherapy 7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Salvage surgery for symptomatic degenerate AVMs after radiosurgery.2003

    • Author(s)
      Kurita H, Nakamura M, Shiokawa Y, et al.
    • Journal Title

      Stereotactic Radiotherapy 7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2003-04-01   Modified: 2016-04-21  

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