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Effects of delta-opioid on neuronal injury after spinal cord ischemia

Research Project

Project/Area Number 15591657
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNara Medical University

Principal Investigator

FURUYA Hitoshi (2004-2006)  Nara Medical University, Anesthesiology, professor, 医学部, 教授 (70183598)

坂本 尚典 (2003)  奈良県立医科大学, 医学部, 助手 (40275334)

Co-Investigator(Kenkyū-buntansha) KAWAGUCHI Masahiko  Nara Medical University, Anesthesiology, Associate professor, 医学部, 助教授 (60275328)
INOUE Satoki  Nara Medical University, Anesthesiology, Assistant professor, 医学部, 講師 (50295789)
古家 仁  奈良県立医科大学, 医学部, 教授 (70183598)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsspinal cord ischemia / rat / opioid / white matter / 軽度低体温 / デルタオピオイド / 神経保護
Research Abstract

The effects of delta-opioid agonist SNC80 on neuronal injury after spinal cord ischemia were evaluated in rats. Spinal ischemia was conducted using 2 Fr Fogarty catheter with hypotension by blood withdrawal. SNC80 was administered intrathecally.
Study 1: The effects of SNC80 on neuronal injury after 9min and 11 min of spinal cord ischemia. SNC80 was intrathecally administered 15 min prior to spinal cord ischemia. The results indicated that intrathecal administration of SNC80 significantly attenuated the neuronal injury in the gray matter in rats subjected to 9 and 11 min of spinal cord ischemia.
Study 2: Changes in white matter injury after spinal cord ischemia were evaluated in a rat model of spinal cord ischemia. White matter injury was evaluated based on the extent of vacuolation and amyloid precursor protein immnoreactivity. The results indicated that both gray and white matter were injured after spinal cord ischemia.
Study 3: The effects of SNC80 on gray and white matter injury after spinal cord ischemia were evaluated in rats under normothermia and hypothermia. The results indicated that SNC80 significantly attenuated white matter damage under normothermia and hypothermia, whereas its effects on gray matter damage were only noted under normothermic conditions.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (10 results)

All 2007 2005 2004 Other

All Journal Article (9 results) Publications (1 results)

  • [Journal Article] Delta opioid receptors stimulation with [d-Ala(2), d-Leu(5)] enkephalin does not provide neuroprotection in the hippocampus in rats subjected to forebrain ischemia2007

    • Author(s)
      Iwata M, Inoue S, Kawaguchi M, et al.
    • Journal Title

      Neurosci Lett 414(3)

      Pages: 242-246

    • Related Report
      2006 Annual Research Report
  • [Journal Article] An evaluation of white matter injury after spinal cord ischemia in rats : a comparison with gray matter injury2005

    • Author(s)
      Kurita N, Kawaguchi M, et al.
    • Journal Title

      Anesth Analg 100

      Pages: 847-854

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] An evaluation of white matter injury after spinal cord ischemia in rats : A comparison with gray matter injury2005

    • Author(s)
      Kurita N, Kawaguchi M, Horiuchi T, Inoue S, Sakamoto T, Nakamura M, Konishi N, Furuya H
    • Journal Title

      Anesth Analg 100

      Pages: 847-854

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] An evaluation of white matter injury after spinal cord ischemia in rats2005

    • Author(s)
      Kurita N, Kawaguchi M, Horiuchi T, et al.
    • Journal Title

      Anesth Analg 100(3)

      Pages: 847-857

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The effects of the delta-opioid agonist SNC80 on hind-limb motor function and neuronal injury after spinal cord ischemia in rats.2004

    • Author(s)
      Horiuchi T, Kawaguchi M, et al.
    • Journal Title

      Anesth An alg 99

      Pages: 235-240

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effects of the delta-opioid agonist SNC80 on hind-limb motor function and neuronal injury after spinal cord ischemia in rats2004

    • Author(s)
      Horiuchi T, Kawaguchi M, Sakamoto T, Kurita N, Inoue S, Nakamura M, Konishi N, Furuya H
    • Journal Title

      Anesth Analg 99

      Pages: 235-240

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effects of the delta-opioid agonist SNC80 on hind-limb motor function and neuronal injury 〜2004

    • Author(s)
      Horiuchi T, Kawaguchi M, Sakamoto T, et al.
    • Journal Title

      Anesth Analg 99(1)

      Pages: 235-240

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The effects of the delta-opioid agonist SNC80 on white matter injury after spinal cord ischemia in normothermic and mildly hypothermic rats.

    • Author(s)
      Horiuchi T, Kawaguchi M, et al.
    • Journal Title

      J Anesth (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effects of the delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats.

    • Author(s)
      Horiuchi T, Kawaguchi M, Kurita N, Inoue S, Sakamoto T, Nakamura M, Konishi N, Furuya H.
    • Journal Title

      J Anesth (in press)

    • NAID

      10024128545

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Publications] T SAKAMOTO, et al.: "Long-term assessment of hind limb motor function and neuronal injury following spinal cord ischemia in rats"Journal of Neurosurgical Anesthesiology. 15. 104-109 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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