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Monitoring of CD15s Ag in Clinical Renal Tx and xenogereic model.

Research Project

Project/Area Number 15591717
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionTokyo Women's Medical University

Principal Investigator

ISHIDA Hideki  TWMU, Dept of Urology, Clinical fellow, 医学部, 助手 (60246543)

Co-Investigator(Kenkyū-buntansha) TANABE Kazunari  TWMU, Dept of Urology, Assist Professor, 医学部, 助教授 (80188359)
MIYAMOTO Naoshi  TWMU, Dept of Urology, Clinical fellow, 医学部, 助手 (50366332)
SHIRAKAWA Hiroki  TWMU, Dept of Urology, Clinical fellow, 医学部, 助手 (60263539)
TOMA Hiroshi  TWMU, Dept of Urology, Professor, 医学部, 教授 (90075549)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsCD15s antigen / blood type incompatible / Renal Transplantation / Xonotransplantation / immuno suppressive regimen / CD15S抗原 / 血液型不適合腎移植 / 免疫抑制剤の調節
Research Abstract

Renal transplantation across the blood barrier is a unique model for investigating the humoral response to different carbohydrate antigens. However, in such a renal transplantation, the characteristics of B cells as well as of the antibodies produced by B cells are less well defined.
In the present study we investigated B cell subsets, i.e., the CD5(+) B-1 and CD5(-) B-2 subsets, by flow cytometric analysis, and their subclasses of antibody, by ELISA, in patients who had undergone renal transplantation across the blood barrier. The subjects consisted of five recipients with good function (group 1) and five recipients with graft loss (group 2) accompanied by antibody-titer elevation after ABO-incompatible renal transplantation.
The B-cell population analysis revealed that CD5(+) B-1 cells temporarily increased in all patients in both groups soon after transplantation, and that CD5(-) B-2 cells significantly increased one month after transplantation only in group 2. The antibody subclasses analysis showed mild elevation of IgG2 and IgM in group 1 as opposed to remarked elevation of IgG2,IgM and IgG1 in group 2.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (20 results)

All 2005 2004 2003 2002 Other

All Journal Article (15 results) Publications (5 results)

  • [Journal Article] Evaluation of Flow PRA in renal transplant recipients2005

    • Author(s)
      石田英樹
    • Journal Title

      Transplant International 18(2)

      Pages: 163-168

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Evaluation of Flow PRA in renal transplant recipients.2005

    • Author(s)
      Hideki ISHIDA, et al.
    • Journal Title

      Transplant Int 18(2)

      Pages: 163-168

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Efficacy of IgM anti-blood type Ab by ELISA2004

    • Author(s)
      石田英樹
    • Journal Title

      Transplant Proceeding 36

      Pages: 2178-2181

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hepatitis C virus decreases in patients with HF therapy2004

    • Author(s)
      石田英樹
    • Journal Title

      Artificial Organs 28

      Pages: 316-318

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Organ donation problems in Japan2004

    • Author(s)
      石田英樹
    • Journal Title

      Saudi Kidney Dis Transplant 15

      Pages: 125-128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Efficacy of IgM anti-blood type antibody monitoring by ELISA after renal transplantation2004

    • Author(s)
      Hideki ISHIDA, et al.
    • Journal Title

      Transplant Proc 36

      Pages: 2178-2181

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hepatitis C virus dealeses in patients with maintainance hemofiltration therapy2004

    • Author(s)
      Hideki ISHIDA, et al.
    • Journal Title

      Artificial Organs 28

      Pages: 316-318

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Efficiency of IgM anti-blood type Ab by ELISA2004

    • Author(s)
      石田英樹
    • Journal Title

      Transplant Proceeding 36

      Pages: 2178-2181

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hepatitis C virus decreases in patients with Hf therapy2004

    • Author(s)
      石田英樹
    • Journal Title

      Artificial Organs 28

      Pages: 316-318

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Therapeutic apheresis for ABO incompatible renal transplant2003

    • Author(s)
      石田英樹
    • Journal Title

      Therapeutic Apheresis 7(6)

      Pages: 520-528

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 腎移植における術後合併症とその対策2003

    • Author(s)
      石田英樹
    • Journal Title

      Medical Science Digest 29

      Pages: 18-21

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Therapeutic apheresis therapy for ABO-incompatible renal transplantiations2003

    • Author(s)
      Hideki ISHIDA, et al.
    • Journal Title

      Therapeutic Apheresis 7(6)

      Pages: 520-528

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Therapeutic apheresis for ABO incompatible renal transplantat2003

    • Author(s)
      石田英樹
    • Journal Title

      Therapeutic Apheresis 7(6)

      Pages: 520-528

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Outcome of ABO incompatible renal transplantation without splenectomy2002

    • Author(s)
      Hideki ISHIDA, et al.
    • Journal Title

      Transplant Int 15(8)

      Pages: 56-58

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Anti-gal A/B, a novel antiblood group antibody identified in recipients of ABO-incompatible kidney allografts2002

    • Author(s)
      Galili Uri, Hideki Ishida et al.
    • Journal Title

      Transplantation 74(11)

      Pages: 1574-1580

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] 石田英樹: "ABO血液型不適合腎移植における新しい知見"腎と透析. 55号. 603-608 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 石田英樹 ら: "日本の腎移植の現状と問題点"慢性腎不全(新しい診断と治療のABC) 最新医学社. 初. 184-190 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hideki ISHIDA, et al.: "Therapeutic Apheresis Therapy for ABO-incompatible Renal Transplantations"Ther Apher. 7・6. 520-528 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 石田英樹 ら: "血液型不適合移植後の患者に認められた抗α-gal抗体の上昇"ABO血液型不適合移植の新戦略2003. 76-80 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 石田英樹 ら: "腎移植における術後合併症とその対策"Medical Science Digest. 29・9. 18-21 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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