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Study on the difference in the relative contribution of lean and fat mass components to bone mineral density with generation.

Research Project

Project/Area Number 15591767
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKagoshima University

Principal Investigator

DOUCHI Tsutomu  Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (60150413)

Co-Investigator(Kenkyū-buntansha) OKI Toshimichi  Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Assistant Professor, 医学部・歯学部附属病院, 講師 (60253879)
IWAMOTO Ichiro  Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Research Associate, 医学部・歯学部附属病院, 助手 (50281225)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsLean body mass / body fat mass / menopause / aging / percentage of body fat / lumbar spine bone mineral density (BMD) / total body BMD / エストロゲン / 骨塩量 / 上半身型体脂肪分布 / 体脂肪量増加 / estrogenの低下 / 身体各部位の筋肉量 / 骨密度 / 閉経前女性 / 閉経後女性 / 体脂肪成分 / 除体脂肪成分
Research Abstract

AIM :
To investigate whether the relative contribution of body composition (lean and fat mass component) to bone mineral density (BMD) differs depending on generation or menopause.
METHODS :
Subjects were 302 premenopausal women aged 30-49 years old and 197 postmenopausal women aged 50-69 years old. They were classified into four subgroups with 10-year increments. Age, height, weight and years since menopause (YSM) were recorded. Lumbar spine (L2-4), total body BMD, body fat mass, lean body mass (LBM), and the percentage of body fat (%fat) were measured using dual-energy X-ray absorptiometry. The correlation of body composition with BMD was investigated.
RESULTS :
The mean age at menopause was 50.2 +/- 4.1 years old. On Pearson's correlation test, LBM was positively correlated with BMD of the two sites in all groups. In a group aged 60-69 years, both the %fat and body fat mass were correlated with BMD. On multiple regression analysis, LBM was the principal BMD determinant in women aged less than 60 years, while body fat mass and percentage fat were the principal BMD determinants in women aged 60-69 years. Mean %fat in the group aged 60-69 years was 35.5 +/- 7.3%, which was significantly higher than that in the group aged 50-59 years (33.0 +/- 6.7%, P<0.05).
CONCLUSION :
Although LBM still influences BMD up to 10 years after menopause, the body fat mass initially influences BMD after 60 years of age. These differences may be attributable to certain aging-related factor(s).

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (41 results)

All 2006 2005 2004 2003 Other

All Journal Article (32 results) Publications (9 results)

  • [Journal Article] Difference in the relative contribution of lean and fat mass components to bone mineral density with generation.2006

    • Author(s)
      Mizuma Nobuhisa
    • Journal Title

      J Obstet Gynaecol Res 32

      Pages: 184-189

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome.2005

    • Author(s)
      Iwamoto Ichiro
    • Journal Title

      Obstet Gynecol 96

      Pages: 870-872

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Zinc finger domain of Snail function as a nuclear localization signal for important β-mediated nuclear import pathway.2005

    • Author(s)
      Yamasaki Hideki
    • Journal Title

      Genes to Cell 10

      Pages: 455-464

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Menopause status influences the relationship between serumghrelin levels and fat mass in healthy women.2005

    • Author(s)
      Iwamoto Ichiro
    • Journal Title

      J Endocrinol Invest 28

      Pages: 405-409

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Metastasis of uterine leiomyosarcome to the pancreas.2005

    • Author(s)
      Iwamoto Ichiro
    • Journal Title

      J Obstet Gynaecol Res 31

      Pages: 531-553

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Discordance in the decline in regional lean and bone mass with advancing age.2005

    • Author(s)
      Kuwahata Riki
    • Journal Title

      J Obstet Gynaecol Res 31

      Pages: 571-575

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The effect of age at menarche on bone mineral density later in life.2005

    • Author(s)
      Nakae Mitsuhiro
    • Journal Title

      The Kagoshima District Journal of the Japanese Obstetrical and Gynecological Society. 13

      Pages: 18-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Correlation between the number of remaining teeth, occlusive force, and percentage of body fat and bone mineral density.2005

    • Author(s)
      Mizuma Nobuhisa
    • Journal Title

      The Kagoshima District Journal of the Japanese Obstetrical and Gynecological Society. 13

      Pages: 27-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome.2005

    • Author(s)
      Iwamoto Ichiro
    • Journal Title

      Obstet Gynecol 96

      Pages: 870-872

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The effect of age at menarche on bone mineral density later in life.2005

    • Author(s)
      Nakae Mistuhiro
    • Journal Title

      The Kagoshima District Journal of the Japanese Obstetrical and Gynecological Society. 13

      Pages: 18-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Body fat patterning in polycystic ovary syndrome women as a predictor of the response to clomiphene.2004

    • Author(s)
      Douchi Tsutomu
    • Journal Title

      Acta Obstet Gynecol Scand 83

      Pages: 838-841

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Verrucous carcinoma of the vulva in Turner syndrome.2004

    • Author(s)
      Iwamoto Ichiro
    • Journal Title

      Gynecol Oncol 92

      Pages: 380-383

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Relationship of ultrasonographic endometrial thickness and uterine size to bone mineral density in postmenopausal women.2004

    • Author(s)
      Douchi Tsutomu
    • Journal Title

      Maturitas 48

      Pages: 219-223

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The leptin receptor in human osteoblasts and the direct effect of leptin on bone metabolism.2004

    • Author(s)
      Iwamoto Ichiro
    • Journal Title

      Gynecological Endocrinology 19

      Pages: 97-104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Overian hyperstimulation syndrome associated with tamoxifen therapy in premenopausal breast cancer patients.2004

    • Author(s)
      Nakae Mitsuhiro
    • Journal Title

      The Kagoshima District Journal of the Japanese Obstetrical and Gynecological Society 12

      Pages: 13-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Relationship of ultrasonographic endometrial thickness anduterine size to bone mineral density in postmenopausal women.2004

    • Author(s)
      Douchi Tsutomu
    • Journal Title

      Maturitas 48

      Pages: 219-223

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ovarian hyperstimulation syndrome associated with tamoxifen therapy in premenopausal breast cancer patients.2004

    • Author(s)
      Nakae Mitsuhiro
    • Journal Title

      The Kagoshima District Journal of the Japanese Obstetrical and Gynecological Society 12

      Pages: 13-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Body fat patterning in polycystic ovary syndrome women as a predictor of the response to clomiphene.2004

    • Author(s)
      Douchi T, Oki T, Nagata Y
    • Journal Title

      Acta Obstetrica et Gynecologica Scandinavica 83

      Pages: 838-841

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Verrucous carcinoma of the vulva in Turner syndrome.2004

    • Author(s)
      Iwamoto I, Kijima Y, Douchi T
    • Journal Title

      Gynecologic Oncology 92

      Pages: 380-383

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Relationship of ultrasonographic endometrial thickness and uterine size to bone mineral density in postmenopausal women.2004

    • Author(s)
      Douchi T, Ijuin M, Ijuin Y
    • Journal Title

      Maturitas 48

      Pages: 219-223

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Fatty acid synthase expression and clinicopathological findings in endometrial cancer.2004

    • Author(s)
      Tsuji T, Yoshinaga M, Douchi T
    • Journal Title

      Acta Obstetrica et Gynecologica Scandinavica 83

      Pages: 586-590

    • Related Report
      2004 Annual Research Report
  • [Journal Article] SOCS1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein.2004

    • Author(s)
      Kamio M, Yoshida T, Douchi T
    • Journal Title

      Oncogene 23

      Pages: 3107-3117

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Uterine lipoleiomyoma : A histopathological review of 17 cases.2004

    • Author(s)
      Aung T, Goto M, Douchi T
    • Journal Title

      Pathology International 54

      Pages: 751-758

    • NAID

      10017450492

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The leptin receptor in human osteoblasts and the direct effect of leptin on bone metabolism.2004

    • Author(s)
      Iwamoto I, Fujino T, Douchi T
    • Journal Title

      Gynecological Endocrinology 19

      Pages: 97-104

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Use of heparin to lower the incidence of phlebitis induced by anti-neoplastic agents used in ovarian cancer.2004

    • Author(s)
      Ikeda T, Douchi T, Nagata Y
    • Journal Title

      Journal of Obstetrics and Gynaecology Research 30

      Pages: 381-385

    • NAID

      10014112850

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ovarian hyperstimulation syndrome associated with tamoxifen therapy in premenopausal breast cancer patients.2004

    • Author(s)
      Nakae M, Iwamoto I, Douch T
    • Journal Title

      The Kagoshima District Journal of the Japanese Obstetrical and Gynecological Society 12

      Pages: 13-15

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Factors affecting bone mineral density (BMD) do not always have a general influence on BMD throughout all stages of the life cycle.2003

    • Author(s)
      Douchi Tsutomu
    • Journal Title

      J Jpn Menopause Soc 11

      Pages: 140-144

    • NAID

      10012826858

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lean body mass and bone mineral density in physically exercising postmenopausal women.2003

    • Author(s)
      Douchi Tsutomu
    • Journal Title

      Maturitas 45

      Pages: 185-190

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Precedence of bone loss over changes in body composition and body fat distribution.2003

    • Author(s)
      Douchi Tsutomu
    • Journal Title

      Maturitas 46

      Pages: 133-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Age-related changes in the strength of correlation of lumbar spine bone mineral density with other regions.2003

    • Author(s)
      Douchi Tsutomu
    • Journal Title

      Maturitas 46

      Pages: 55-59

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Relationship of head lean mass to regional bone mineral density in elderly postmenopausal women.2003

    • Author(s)
      Douchi Tsutomu
    • Journal Title

      Maturitas 46

      Pages: 225-230

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Changes in anthropometry with testosterone therapy in a female with gender identity disorder.2003

    • Author(s)
      Yamasaki Hideki
    • Journal Title

      Endocr J 50

      Pages: 729-731

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Matsuo T, Douchi T, Nakae M, Uto H, Oki T, Nagata Y: "Relationship of upper body fat distribution to higher regional lean mass and bone mineral density."Journal of Bone and Mineral Metabolism. 21. 179-184 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Douchi T, Kuwahata T, Iwamoto I, Nagata Y: "Changes in serum leptin levels during GnRH agonist therapy."Endocrin Journal. 50. 355-359 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Douchi T, Matsuo T, Uto H, Oki T, Kuwahata R, Nagata Y: "Lean body mass and bone mineral density in physically exercising postmenopausal women."Maturitas. 45. 185-190 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Douchi T, Kosha S, Uto H, Oki T, Nakae M, Nagata Y: "Precedence of bone loss over changes in body composition and body fat distribution."Maturitas. 46. 133-138 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Douchi T, Kuwahata R, Matsuo T, Nagata Y: "Age-related changes in the strength of correlation of lumbar spine bone mineral density with other regions."Maturitas. 46. 55-59 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iwamoto I, Fujino T, Douchi T, Nagata Y: "Association of estrogen receptor α and β3-adrenergic receptor polymorphisms with endometrial cancer."Obstetrics and Gynecology. 102. 506-511 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iwamoto I, Kijima Y, Fujino T, Yoshinaga M, Douchi T: "Verrucous carcinoma of the vulva in Turner syndrome."Gynecologic Oncology. 92. 380-383 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamasaki H, Douchi T, Nagata Y: "Changes in anthropometry with testosterone therapy in a female with gender identity disorder."Endocrine Journal. 50. 729-731 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshimitsu N, Douchi T, Nagata Y, Kadota T: "Circulating leptin levels during the perioperation period."The Kagoshima District Journal of the Japanease Obstetrical And Gynecological Society. 11. 20-28 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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