THE EFFECT OF ADENOSINE METABOLISM ON THE EXPRESSION OF P-SLECTIN IN POSTMENOPAUSAL WOMEN.
| Project/Area Number |
15591785
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
YONEYAMA Yoshio NIPPON MEDICAL SCHOOL, OB-GYN, ASSISTANT PROFESSOR, 医学部, 助教授 (00201096)
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| Co-Investigator(Kenkyū-buntansha) |
SAWA Rintaro NIPPON MEDICAL SCHOOL, OB-GYN, LECTURER, 医学部, 講師 (30267174)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Adenosine / P-selectin / Platelet / Menopause / Cell adhesive molecule / atherosclerosis |
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| Research Abstract |
[PURPOSE]The purpose of this study is to evaluate the relationship between adenosine and P-selectin, platelet activation marker in menopausal women,
[METHOD]We measured plasma adenosine and the expression of P-selectin by flowcytometry,in menopausal women, and then evaluate the relationship between them.
[RESULTS]The reduction of plasma adenosine in menopausal women nay be associated with the inrease in the the expression of P-selectin in menopausal women,
[CONCLUSION]This study has suggested that plasma adenosine may play role in the regulation of P-selecin, which eventually dampens to worsen the atherosclerosis in menopausal women.
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Report
(3 results)
Research Products
(8 results)
