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A study of new mechanisms by basophils on immunotherapy for allergic rhinitis

Research Project

Project/Area Number 15591805
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionMie University

Principal Investigator

YUTA Atsushi  Mie University, Hospital, Assistant professor, 医学部附属病院, 講師 (80293778)

Co-Investigator(Kenkyū-buntansha) MAJIMA Yuichi  Mie University, Hospital, Professor, 大学院・医学系研究科, 教授 (60024791)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsallergic rhinitis / immunotherapy / basophil / histamine release test / 好塩基 / ヒスタミン遊離率 / スギ花粉症
Research Abstract

We showed the clinical and economical efficacy of Immunotherapy (IT) in patients with cedar pollinosis, by following these patients for three years. We also investigated histamine release rate (HRR) to investigate whether HRT can lead to a new mechanism of IT. As the result, HRR was suppressed by IT, and the suppression was larger in the case that IT was effective. The present study investigated histamine release from basophils, which is not involved in Th1/Th2 balance-based lymphocyte responses. Activation of basophils may have been inhibited, and this is very interesting because it may lead to a new mechanism, unlike previous investigations of the mechanism of IT focusing on lymphocytes. The investigation of the degree of inhibition of HRR and the clinical effects during the cedar pollen scattering period suggested that HRR may be used as a biomarker of IT.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (5 results)

All 2005 2004

All Journal Article (5 results)

  • [Journal Article] 2005年三重県におけるスギ花粉飛散予想2005

    • Author(s)
      湯田厚司 ほか
    • Journal Title

      東海花粉症研究会会誌 16

      Pages: 22-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 2004年三重県におけるスギ・ヒノキ科花粉飛散結果2004

    • Author(s)
      湯田 厚司
    • Journal Title

      東海花粉症研究会会誌 15・2

      Pages: 19-22

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 2004年三重県におけるスギ・ヒノキ科花粉飛散予想2004

    • Author(s)
      湯田 厚司
    • Journal Title

      東海花粉症研究会会誌 15・1

      Pages: 3-6

    • Related Report
      2004 Annual Research Report
  • [Journal Article]2004

    • Author(s)
      湯田 厚司
    • Journal Title

      鼻アレルギーフロンティア 4・2

      Pages: 36-42

    • Related Report
      2004 Annual Research Report
  • [Journal Article]2004

    • Author(s)
      湯田 厚司
    • Journal Title

      アレルギーの臨床 24・2

      Pages: 66-72

    • Related Report
      2004 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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