| Project/Area Number |
15591820
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
NAKASHIMA Torahiko Kyushu University, Faculty of Medicine, Department of OtorhinoLaryngology, Assistant Prof., 医学研究院, 講師 (00284505)
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| Co-Investigator(Kenkyū-buntansha) |
YASUMATSU Ryuji Kyushu University, Faculty of Medicine, Department of Otorhinolaryngology, 病院・医員 (00444787)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | Head and Neck Cancer / SCC Antigen / Sinonasal papilloma / serpin / 癌浸潤 |
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| Research Abstract |
Serine proteases have important roles in tumor invasion and metastasis and their inhibitors, serine protease inhibitors (serpins) are attractive targets for therapeutic strategies. On chromosome 18q21,there is a cluster of serpins ; maspin, headpin, and SCCA1. Others and we have reported that the expression of these serpins are down-regulated in HNSCC cells as compared to normal squamous epithelial cells. We have hypothesized that expression of SCCA1 is biologically disadvantageous to HNSCC cells. The in vitro and in vivo invasion of established HNSCC cell lines stably transfected with a mammalian expression vector with SCCA1 cDNA was significantly inhibited compared to the vector control. SCCA1 may function to inhibit the invasive potential of HNSCC.
We also reported that Serum SCC antigen level has a correlation with disease status of sinonasal inverted papilloma(IP) and has a potential to serve as a useful tool for monitoring the course of disease. SCC antigen is a reliable tumor marker in the management ofsinonasal IPs.
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