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Changes of distribution of neuropeptides in the sensory and autonomic ganglia in the head and neck region with chronically hypoxic exposure.

Research Project

Project/Area Number 15591824
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionYokohama City University

Principal Investigator

HIDEKI Matsuda  Yokohama City University, School of Medice, Assistant Professor, 医学部, 講師 (80305458)

Co-Investigator(Kenkyū-buntansha) KUSAKABE Tatsumi  Kokushikan University, Department of Sport and Medical Science, Professor, 体育学部, 教授 (80117663)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsChronic hypoxia / Carotid body / Trigeminal ganglion / Immunohistochemistry / Neuropeptide / In situ hybridization / Isocapnic hypoxia / Hypercapnic hypoxia / Hypocapnic hypoxia / In situ hybridization
Research Abstract

1. Changes of neuropeptides in the carotid body under systemic hypoxia.
NPY immunoreactive nerve fibers in hypercapnic hypoxia are more than other hypoxia. VIP fibers in isocapnic and hypocapnic hypoxia are more than control. These results suggest that vascular expansion in the hypoxic carotid body is caused by VIP, and NPY is related to inhibition of vascular expansion in the hypercapnic hypoxic carotid body. (Adv. Exp. Med. Biol. 536:611-617, 2003.)
2. The time course of changes of neuropeptides in the hypoxic carotid body.
SP, CGRP and VIP fibers in the carotid body increase 4 weeks after hypoxic exposure, but SP and CGRP fibers decrease 8 weeks after exposure. NPY fibers show no changes. These result suggest that adaptation of neuropeptides in the carotid body to hypoxia is completed 8 weeks after exposure.
(Histol. Histopathol. 18:409-418, 2003).
3. Morphological changes of the carotid body after the termination of hypoxic exposure.
The size of the carotid body under hypoxia is diminished after the termination of hypoxic exposure.
(Histol. Histopathol. 19:1133-1140, 2004.)
4. Changes of neuropeptides in the rat carotid body after the termination of hypoxic exposure.
NPY fibers increase one week after the termination of hypoxic exposure, and VIP fibers decrease at the same time. It is suggested that some neuropeptides are related to morphological changes of the carotid body with arterial O2 tension. (Histol. Histopathol. 19:1133-1140, 2004.)
5. In situ hybridization
Changes of mRNA of neuropeptides in the trigeminal and sphenopalatine ganglia with hypoxic exposure have been observed using in situ hybridization.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (18 results)

All 2005 2004 2003 Other

All Journal Article (15 results) Publications (3 results)

  • [Journal Article] Morphological changes in the rat carotid body in acclimatization and deacclimatization to hypoxia.2005

    • Author(s)
      H Matsuda
    • Journal Title

      Adv.Exp.Med.Biol. In press

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of carbon dioxide on the structure of the carotid body.2005

    • Author(s)
      T Kusakabe
    • Journal Title

      Adv.Exp.Med.Biol. In press

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hypoxic adaptation of the rat carotid body.2005

    • Author(s)
      T Kusakabe
    • Journal Title

      Histol.Histopathol. In press

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Morphological changes in the rat carotid body in acclimatization and deacclimatization to hypoxia2005

    • Author(s)
      Matsuda, H.
    • Journal Title

      Adv. Exp. Med. Biol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of carbon dioxide on the structure of the carotid body2005

    • Author(s)
      Kusakabe, T.
    • Journal Title

      Adv. Exp. Med. Biol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hypoxic adaptation of the rat carotid body2005

    • Author(s)
      Kusakabe, T.
    • Journal Title

      Histol. Histopathol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Morphological changes in the rat carotid body 1, 2, 4, and 8 weeks after the termination of chronically hypocapnic hypoxia.2004

    • Author(s)
      T Kusakabe
    • Journal Title

      Histol.Histopathol. 19

      Pages: 1133-1140

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Morphological changes in the rat carotid body 1,2,4 and 8 weeks after the termination of chronically hypocapnic hypoxia2004

    • Author(s)
      Kusakabe, T.
    • Journal Title

      Histol. Histopathol. 19

      Pages: 1133-1140

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of carbon dioxide on the structure of the carotid body : A comparison between normoxic and hypoxic conditions.2004

    • Author(s)
      T Kusakabe
    • Journal Title

      Histol.Histopathol. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Nitric oxide and calcium binding protein in hypoxic rat carotid body.2003

    • Author(s)
      H Matsuda
    • Journal Title

      Adv.Exp.Med.Biol. 536

      Pages: 353-358

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Peptidergic innervation in the rat carotid body after 2, 4 and 8 weeks of hypocapnic hypoxic exposure.2003

    • Author(s)
      T Kusakabe
    • Journal Title

      Histol.Histopathol. 18

      Pages: 409-418

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Rat carotid bodies in systemic hypoxia. Involvement of arterial CO2 tension in morphological changes.2003

    • Author(s)
      T Kusakabe
    • Journal Title

      Adv.Exp.Med.Biol. 536

      Pages: 611-617

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nitric oxide and calcium binding protein in hypoxic rat carotid body2003

    • Author(s)
      Matsuda, H.
    • Journal Title

      Adv. Exp. Med. Biol. 536

      Pages: 353-358

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Peptidergic innervation in the rat carotid after 2,4 and 8 weeks of hypocapnic hypoxic exposure2003

    • Author(s)
      Kusakabe, T.
    • Journal Title

      Histol. Histopathol. 18

      Pages: 409-418

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Rat carotid bodies in systemic hypoxia. Involvement of arterial CO2 tension in morphological changes2003

    • Author(s)
      Kusakabe, T.
    • Journal Title

      Adv. Exp. Med. Biol. 536

      Pages: 611-617

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] H Matsuda: "Nitric oxide and calcium binding protein in hypoxic rat carotid body"Adv.Exp.Med.Biol.. 536. 353-358 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T Kusakabe: "Peptidergic innervation in the rat carotid body after 2, 4 and 8 week of hypocapnic hypoxic exposure"Histol.Histopathol.. 18. 409-418 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T Kusakabe: "Rat carotid bodies in systemic hypoxia. Involvement of arterial CO2 tension in morphological changes"Adv.Exp.Med.Biol.. 536. 611-617 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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