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A study of risk factors for intractable otitis media and nasopharyngeal transmission of causative pathogen

Research Project

Project/Area Number 15591828
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionWakayama Medical University

Principal Investigator

TAMURA Shinji (2004-2005)  Wakayama Medial University, Faculty of medicine, Assistant Professor, 医学部, 講師 (10244724)

保富 宗城 (2003)  和歌山県立医科大学, 医学部, 講師 (90336892)

Co-Investigator(Kenkyū-buntansha) YAMANAKA Noboru  Wakayama Medial University, Faculty of medicine, Professor, 医学部, 教授 (10136963)
HOTOMI Muneki  Wakayama Medial University, Faculty of medicine, Assistant Professor, 医学部, 講師 (90336892)
YAMAUCHI Kazuma  Wakayama Medial University, Faculty of medicine, Instructor, 医学部, 助手 (80336891)
田村 真司  和歌山県立医科大学, 医学部, 講師 (10244724)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsacute otitis media / antimicrobial resistant pathogen
Research Abstract

1. Risk factors for intractable otitis media
Clinical course of pediatric acute otitis media were evaluated in 368 cases (10 to 86 months olds, 200 males, 168 females) by a scoring system depending on the clinical symptoms such as otalgia, fever, and irritability / crying and tympanic membrane finding including bulging, redness and obliteration of light corn.
(1) Correlation between nasopharyngeal pathogens and severity.
S.pneumoniae were frequently identified in severe cases, while in non-severe cases M.catarrhalis or no pathogen were identified.
(2) Risk factors for prolonged symptoms.
Young ages, severity at the first visit, identification of S.pneumoniae were the risk factors for prolonged symptoms (Odds ratio : age 9.64, severity 0.28).
(3) Risk factors for prolonged abnormal finding in tympanic membrane
Young ages (<2 y.o.), severity, nasopharyngeal colonization with drug resistant S.pnuemoniae were risk factors for prolonged abnormalities in tympanic membrane (Odds : age 3.68, nasopharyngeal colonization with drug resistant pathogens 1.9)
(4) Risk factors for antimicrobial treatment
Young age (<2), severe cases, and nasopharyngeal colonization with drug resistant S.pnuemoniae were risk factors for treatment failure in severe cases.
(5) Risk factors for antimicrobial treatment
Young age (<2), severe cases, and nasopharyngeal colonization were risk factors for necessity of antimicrobial treatment in non-severe cases.
2. Detection of drug resistant pathogens
30% of S.pneumoniae isolated from the nasopharynx had mutations in pbp genes. β-lactamase nonproducing ampicillin resistant H.influenzae (BLNAR) were isolated in about 20%.
3. Nasopharyngeal transmission of causative pathogens
Causative pathogens were transmitted among sibling.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (24 results)

All 2006 2005 2004 2002 2000

All Journal Article (21 results) Book (3 results)

  • [Journal Article] Antimicrobial resistance of Haemophilus influenzae isolated from the nasopharynx of Japanese children with acute otitis media.2006

    • Author(s)
      Hotomi M
    • Journal Title

      Acta Otolaryngol. 126・3

      Pages: 240-247

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High prevalence of S.pneumoniae with mutations in pbp1a, pbp2x, and pbp2b genes of penicillin-binding proteins in the nasopharynx in children in Japan.2006

    • Author(s)
      Hotomi M
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec. 68・3

      Pages: 139-145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evaluation of serotypes of Streptococcus pneumoniae isolated from otitis media patients by multiplex polymerase chain reaction.2006

    • Author(s)
      Billal DS
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec. 68・3

      Pages: 135-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Antimicrobial resistance of Haemophilus influenzae isolated from the nasopharynx of Japanese children with acute otitis media.2006

    • Author(s)
      Hotomi M, Fujihara, Sakai A, Billal DS, Shimada J, Suzumoto M, Yamanaka N.
    • Journal Title

      Acta Otolaryngol. 126(3)

      Pages: 240-247

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High prevalence of Streptococcus pneumoniae with mutations in pbp1a, pbp2x, and pbp2b genes of penicillin-binding proteins in the nasopharynx in children in Japan.2006

    • Author(s)
      Hotomi M, Billal DS, Shimada J, Suzumoto M, Yamauchi K, Fujihara K, Yamanaka N.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec. 68(3)

      Pages: 139-145

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evaluation of serotypes of Streptococcus pneumoniae isolated from otitis media patients by multiplex polymerase chain reaction.2006

    • Author(s)
      Billal DS, Hotomi M, Tasnim S, Fujihara K, Yamanaka N.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec. 68(3)

      Pages: 135-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evaluation of mutations in penicillin binding protein-3 gene of non-typeable H.influenzae isolated from the nasopharynx of children with acute otitis media.2005

    • Author(s)
      Sakai A
    • Journal Title

      Acta Otolaryngol. 125・2

      Pages: 180-183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increase of macrolide-resistant Streptococcus pneumoniae-expressing mefE or ermB gene in the nasopharynx among children with otitis media.2005

    • Author(s)
      Hotomi M
    • Journal Title

      Laryngoscope. 115・2

      Pages: 317-320

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Treatment and outcome of severe and non-severe acute otitis media.2005

    • Author(s)
      Hotomi M
    • Journal Title

      Eur J Pediatr. 164・1

      Pages: 3-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Evaluation of mutations in penicillin binding protein-3 gene of non-typeable Haemophilus influenzae isolated from the nasopharynx of children with acute otitis media.2005

    • Author(s)
      Sakai A, Hotomi M, Billal DS, Yamauchi K, Shimada J, Tamura S, Fujihara K, Yamanaka N.
    • Journal Title

      Acta Otolaryngol. 125(2)

      Pages: 180-183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increase of macrolide-resistant Streptococcus pneumoniae-expressing mefE or ermB gene in the nasopharynx among children with otitis media.2005

    • Author(s)
      Hotomi M, Billal DS, Shimada J, Suzumoto M, Yamauchi K, Fujihara K, Yamanaka N.
    • Journal Title

      Laryngoscope. 115(2)

      Pages: 317-320

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Treatment and outcome of severe and non-severe acute otitis media.2005

    • Author(s)
      Hotomi M, Yamanaka N, Samukawa T, Suzumoto M, Sakai A, Shimada J, Ikeda Y, Faden H.
    • Journal Title

      Eur J Pediatr. 164(1)

      Pages: 3-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Treatment and outcome of severe and non-severe acute otitis media.2005

    • Author(s)
      Hotomi M, Yamanaka N, Samukawa T, Suzumot M, Sakai A, Shimada J, Ikeda Y, Faden H.
    • Journal Title

      Eur J Pediatr. 164

      Pages: 3-8

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genotyping of Streptococcus pneumoniae and Haemophilus influenzae isolated from paired middle ear fluid and nasopharynx by pulsed-field gel electrophoresis.2004

    • Author(s)
      Hotomi
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec. 66・5

      Pages: 233-240

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Factors associated with clinical outcomes in acute otitis media.2004

    • Author(s)
      Hotomi M
    • Journal Title

      Ann Otol Rhinol Laryngol. 113・10

      Pages: 846-852

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genotyping of Streptococcus pneumoniae and Haemophilus influenzae isolated from paired middle ear fluid and nasopharynx by pulsed-field gel electrophoresis.2004

    • Author(s)
      Hotomi M, Yamanaka N, Billal DS, Sakai A, Yamauchi K, Suzumoto M, Takei S, Yasui N, Moriyama S, Kuki K.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec. 66(5)

      Pages: 233-240

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Factors associated with clinical outcomes in acute otitis media.2004

    • Author(s)
      Hotomi M, Yamanaka N, Shimada J, Ikeda Y, Faden H.
    • Journal Title

      Ann Otol Rhinol Laryngol. 113(10)

      Pages: 846-852

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Household transmission of Streptococcus pneumoniae among siblings with acute otitis media.2002

    • Author(s)
      Hotomi M
    • Journal Title

      J Clin Microbiol. 40・5

      Pages: 1851-1853

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nasopharyngeal carriage of drug-resistant S.pneumoniae in children with acute otitis media evaluated by PCR-based genotyping of penicillin-binding proteins.2002

    • Author(s)
      Hotomi M
    • Journal Title

      Acta Otolaryngol. 122・1

      Pages: 72-77

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Household transmission of Streptococcus pneumoniae among siblings with acute otitis media.2002

    • Author(s)
      Shimada J, Yamanaka N, Hotomi M, Suzumoto M, Sakai A, Ubukata K, Mitsuda T, Yokota S, Faden H.
    • Journal Title

      J Clin Microbiol. 40(5)

      Pages: 1851-1853

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nasopharyngeal carriage of drug-resistant Streptococcus pneumoniae in children with acute otitis media evaluated by polymerase chain reaction-based genotyping of penicillin-binding proteins.2002

    • Author(s)
      Hotomi M, Yamanaka N, Faden H, Shimada J, Suzumoto M, Sakai A, Saito T, Kuki K.
    • Journal Title

      Acta Otolaryngol. 122(1)

      Pages: 72-77

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 小児中耳炎のマネージメント2006

    • Author(s)
      山中昇
    • Publisher
      医薬ジャーナル
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 薬剤耐性菌による上・下気道感染症に対する治療戦略2002

    • Author(s)
      山中昇
    • Publisher
      金原出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 変貌する急性中耳炎2000

    • Author(s)
      山中昇
    • Publisher
      金原出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2003-04-01   Modified: 2016-04-21  

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