• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A study regarding the mechanism of hearing loss in development of endolymphatic hydrops in Meniere's disease

Research Project

Project/Area Number 15591829
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKITASATO UNIVERSITY

Principal Investigator

NAGANUMA Hideaki  Kitasato University, School of Medicine, Assistant Professor, 医学部, 講師 (00198342)

Co-Investigator(Kenkyū-buntansha) YAMASHINA Shohei  Kitasato University, School of Medicine, Professor, 医学部, 教授 (90013987)
KAWAHARA Katsumasa  Kitasato University, School of Medicine, Professor, 医学部, 教授 (70134525)
鈴木 喜郎  北里大学, 医学部, 助手 (40348503)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsVasopressin / V-2receptor / endolymphatic hydrops / aquaporin / AQP-2 / dehydration / Meniere disease / メニコール病 / メニエール病 / ADH / 抗利尿ホルモン / EP
Research Abstract

It was thought that the disorder of accommodation in water transport in membranous labyrinth let the homeostatic function of ion transport in endo- and peri-lymph failure. This fail caused to endolymphatic hydrops that was a morphological disorder in inner ear. Though the mechanism of its occurrence still remains unclear, various lines of experimental and clinical evidence indicate a possible roll of AVP in development of endolymphatic hydrops in MD. In our previous study entitled "A study regarding the mechanism in development of endolymphatic hydrops in MD" (Grant-in-Aid for Scientific Research (C)(2), the hearing loss was occurred in the animal model by administering AVP. This hearing loss was sometime repaired. The purpose in present study was to elucidate the mechanism of this hearing loss.
The dose of AVP in the experiments was 0.02units/g. It was investigated whether the endolymphatic hydrops was formed by administration of same dose of AVP. As the results, the endolymphatic hydrops was not formed in light microscope level by administration of same dose of AVP. These results mean that the hearing loss was occurred without the morphological disorder of endolymphatic hydrops. As the next step, it was necessary to investigate some physiological disorders in administration of AVP.
Therefore, it was investigated whether the cochlear endolymphatic D-C Potential (EP) had an influence on the administrating AVP in our animal model. As the results, EP was decreased statistically in 2-10 minutes after administrating of AVP. It was thought that the function of stria vascularis was changed before the formation of endolymphatic hydrops and hearing was impaired.
In next study, it was planed that the function and morphological change of stria vascularis were investigated by administrating AVP.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (5 results)

All 2005 2003 Other

All Journal Article (4 results) Publications (1 results)

  • [Journal Article] Three-dimensional Recoastruction of the Human Semicircular Canals and Measurement of Each Membranous Canal Plane Defmed by Reid's Scereotactic Coordinates2005

    • Author(s)
      Shinichiro Hashimoto, etal
    • Journal Title

      Annals of otology, Rhinology, Laryngology 114-12

      Pages: 934-938

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Three-dimensional analysis of morphological aspects of the human utricular macula2003

    • Author(s)
      Hideaki Naganuma, etal
    • Journal Title

      Annals of otology, Rhinology, Laryngology 112-5

      Pages: 419-424

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Three-dimensional analysis of morphological aspects of the human utricular macula2003

    • Author(s)
      Hideaki Naganuma, et al.
    • Journal Title

      Annals of otology, Rhinology & Laryngology No.112

      Pages: 419-424

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Three-Dimensional Reconstruction of the Human Semicircular Canals and Measurement of Each Membranous Canal Plane Defined by Reid's Stereotactic Coordinates

    • Author(s)
      Shinishiro Hashimoto, et al.
    • Journal Title

      Annals of otology, & Laryngology No.114(12)

      Pages: 934-938

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Naganuma H., Tokumasu K., Okamoto M, Yamashina S: "THREE-DIMENSIONAL ANALYSIS OF MORPHOLOGICAL ASPECTS OF THE HUMAN UTRICULAR MACULA"Ann Otol Rhinol Laryngol. 112(5). 419-424 (2003)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi