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Basic research for wavefront-guided refractive surgery : The evaluation of effects of aberrations and scatterings on the optical function of the eye

Research Project

Project/Area Number 15591854
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

MAEDA Naoyuki  Osaka University, Graduate School of Medicine, Endowed Chair Professor, 医学系研究科, 寄附講座教授 (00273623)

Co-Investigator(Kenkyū-buntansha) NISHIDA Kohji  Tohoku University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (40244610)
FUJIKADO Takashi  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (50243233)
TANO Yasuo  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (80093433)
渡辺 仁  大阪大学, 医学系研究科, 助教授 (60252673)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordswavefront technology / refractive surgery / aberration / scattering / visual function / irregular astigmatism / wavefront sensor / excimer laser
Research Abstract

As one of the cause of post-operative complications, the mechanism of transient keratectasia in association with a marked intraocular pressure (IOP) elevation was shown.
Monocular triplopia was reported by middle-aged patients with mild nuclear cataract and high myopia. Wavefront analyses suggested that the triple configuration was caused by the combined increase of the trefoil and spherical aberration in lenses with nuclear cataract.
The transplantation of tissue-engineered epithelial cell sheets can successfully prevent the development of corneal haze after excimer laser keratectomy.
The tear break-up time measured by Hartmann-Shack aberrometer may be used as a practical measure of tear break-up.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (16 results)

All 2006 2005 2004 Other

All Journal Article (13 results) Publications (3 results)

  • [Journal Article] Wavefront analysis of eyes with cataracts in patients with monocular triplopia.2006

    • Author(s)
      Aya Ki, et al.
    • Journal Title

      Ophthal Physiol Opt 26

      Pages: 65-70

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transplantation of tissue-engineered epithelial cell sheets after excimer laser photoablation reduces postoperative corneal haze.2006

    • Author(s)
      Hayashida Yasutaka, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci 47

      Pages: 552-557

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tear film break-up time evaluated by real-time Hartmann-Shack wavefront sensing.2006

    • Author(s)
      Toshifumi Mihashi, et al.
    • Journal Title

      Jpn J Ophthalmol 50

      Pages: 85-89

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Wavefront analysis of eyes with cataracts in patients with monocular triplopia.2006

    • Author(s)
      Aya Kim, Kenichiro Bessho, Yoshitaka Okawa, Naoyuki Maeda, Yasuo Tano, Yoko Hirohara, Toshifumi Mihashi, Takashi Fujikado
    • Journal Title

      Ophthal Physiol Opt. 26

      Pages: 65-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transplantation of tissue-engineered epithelial cell sheets after excimer laser photoablation reduces postoperative corneal haze.2006

    • Author(s)
      Hayashida Y, Nishida K, Yamato M, Yang J, Sugiyama H, Watanabe K, Hon Y, Maeda N, Kikuchi A, Okano T, Tano Y
    • Journal Title

      Invest Ophthalmol Vis Sci. 47

      Pages: 552-557

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tear film break-up time evaluated by real-time Hartmann-Shack wavefront sensing2006

    • Author(s)
      Toshifumi Mihashi, Yoko Hirohara, Shizuka Koh, Sayuri Ninomiya, Naoyuki Maeda, Takashi Fujikado
    • Journal Title

      Jpn J Ophthalmol. 50

      Pages: 85-89

    • NAID

      10020385747

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Wavefront analysis of eyes with cataracts in patients with monocular triplopia2006

    • Author(s)
      Aya Kim et al.
    • Journal Title

      Ophthal Physiol Opt. 26

      Pages: 65-70

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transplantation of tissue-engineered epithelial cell sheets after excimer laser photoablation reduces postoperative corneal haze.2006

    • Author(s)
      Yasutaka Hayashida et al.
    • Journal Title

      Invest Ophthalmol Vis Sci. 47

      Pages: 552-557

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transient keratectasia caused by intraocular pressure elevation after laser in situ keratomileusis.2005

    • Author(s)
      Atsuko Toshino, et al.
    • Journal Title

      J Cataract Refract Surg 31

      Pages: 202-204

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transient keratectasia caused by intraocular pressure elevation after laser in situ keratomileusis.2005

    • Author(s)
      Atsuko Toshino, Toshihiko Uno, Yuichi Ohashi, Naoyuki Maeda, Tetsuro Oshika
    • Journal Title

      J Cataract Refract Surg. 31

      Pages: 202-204

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transient keratectasia caused by intraocular pressure elevation after laser in situ keratomileusis.2005

    • Author(s)
      Atsuko Toshino et al.
    • Journal Title

      J Cataract Refract Surg. 31

      Pages: 202-204

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Light scattering and optical aberrations as objective parameters to predict visual deterioration in eyes with cataracts.2004

    • Author(s)
      Takashi Fujikado et al.
    • Journal Title

      J Cataract Refract Surg 30

      Pages: 1198-1208

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Age-related changes in ocular and corneal aberrations.2004

    • Author(s)
      Takashi Fujikado et al.
    • Journal Title

      Am J Ophthalmol 138

      Pages: 143-146

    • Related Report
      2004 Annual Research Report
  • [Publications] Hitoshi Hayashi: "Sclerotic scattering illumination during phototherapeutic keratectomy for better visualization of corneal opacity"Am J Ophthalmol. 135. 559-561 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sayuri Ninomiya: "Wavefront analysis in eyes with acommodative spasm"Am J Ophthalmol. 136. 1161-1163 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Naoyuki Maeda: "Keratoconus detection by corneal topographic examination"Contemporary Ophthalmology. 2(6). 1-6 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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