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Immunological analysis of dendritic cell-osteopontin system in the remodeling of serious ocular allergy

Research Project

Project/Area Number 15591869
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionFukuoka University (2005)
Yokohama City University (2003-2004)

Principal Investigator

UCHIO Eiichi  Fukuoka University, School of Medicine, Professor, 医学部, 教授 (70232840)

Co-Investigator(Kenkyū-buntansha) 西出 忠之  横浜市立大学, 医学部, 助手 (90347344)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
KeywordsVernal keratoconjunctivitis / Langerhans cell / Dendritic cell / Osteopontin / Atopic dematitis / Interleukin-4 / アレルギー性結膜炎 / マウス / カドヘリン / インテグリン / 結膜 / アレルギー / ステロイド / マスト細胞 / 好酸球 / T細胞 / 低親和性IgE受容体
Research Abstract

The frequency of IL-4-producing conjunctival T cells in patients with vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (VKC) were significantly higher than that in patients with allergic conjunctivitis (AC). The frequencies of IL-4-producing conjunctival CD4+ T cells of the patients with AC, AKC, or VKC were significantly higher than those of peripheral blood CD4+ T cells of the same disease. Further, increased frequency of P-selectin ligand expressing IL-4-producing T cells was observed in conjunctiva compared to that in PBMC of the patients with allergic conjunctival diseases. The frequencies of IL-4-producing peripheral blood T cells in the patients with ACD were sig-nificantly higher than that in normal controls. Tear levels of cytokines, interleukin-2(IL-2), interferon gamma (IFN-γ), IL-4, IL-5, IL-6, IL-8 and IL-13, in 49 patients with ACD (allergic conjunctivitis 14 cases, atopic keratoconjunctivitis 14 cases and vernal keratoconjunctivitis 21 cases) were measured with ELISA (enzyme-linked immunosorbent assay) method. Correlation between cytokines were statistically analyzed. Significant correlations were observed between IFN-g and IL-13, IL-4 and IL-13, IL-5 and IL-6, and IL-8 and IL-13. These results suggest that IL-4-producing T cells that have infiltrated into the conjunctiva play an important role in the immunopathogenesis of allergic conjunctival diseases, and P-selectin ligand is involved in the entry of T cells into allergic inflammatory site and correlation between tear cytokines show various patterns suggesting the complexity and redundancy of cytokines.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (28 results)

All 2005 2004 2003 Other

All Journal Article (19 results) Book (2 results) Publications (7 results)

  • [Journal Article] 春季カタルの重症化に関与するアレルギー学的要因の多変量解析2005

    • Author(s)
      内尾英一, 伊藤由起, 佐藤貴之, 角澤比呂志, 門之園一明
    • Journal Title

      臨床眼科 59

      Pages: 187-192

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] アレルギー性結膜疾患における涙液サイトカイン濃度の相関2005

    • Author(s)
      伊藤由起, 佐藤貴之, 大野智子, 山根真, 内尾英一, 他
    • Journal Title

      臨床眼科 59

      Pages: 1862-1867

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] スギ花粉以外の抗原によるアレルギー性結膜炎の薬物療法2005

    • Author(s)
      福島敦樹, 中川やよい, 内尾英一, 岡本茂樹, 深川和己, 他
    • Journal Title

      あたらしい眼科 22

      Pages: 225-229

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 春季カタルの重症化に関与するアレルギー学的要因の多変量解析2005

    • Author(s)
      内尾英一, 伊藤由起, 永瀬聡子, 野村英一, 西出忠之, 門之園一明
    • Journal Title

      臨床眼科 59

      Pages: 187-192

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ウイルス性結膜炎の新しい薬物治療2005

    • Author(s)
      内尾英一
    • Journal Title

      日本眼科学会雑誌 109

      Pages: 962-985

    • Related Report
      2005 Annual Research Report
  • [Journal Article] アレルギー科診療における眼病変2005

    • Author(s)
      内尾英一
    • Journal Title

      アレルギー 54

      Pages: 1250-1253

    • NAID

      110003479661

    • Related Report
      2005 Annual Research Report
  • [Journal Article] アレルギー性結膜疾患の診断と治療2005

    • Author(s)
      内尾英一
    • Journal Title

      日本の眼科 76

      Pages: 337-341

    • Related Report
      2005 Annual Research Report
  • [Journal Article] アレルギー性結膜疾患治療薬2005

    • Author(s)
      内尾英一
    • Journal Title

      眼薬理 19

      Pages: 52-54

    • NAID

      10016567574

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 病型分類と臨床所見の評価基準2005

    • Author(s)
      内尾英一
    • Journal Title

      あたらしい眼科 22

      Pages: 719-724

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Acute asthma attack caused by ophthalmic application of anti-allergic agents2004

    • Author(s)
      Uchio E, Kadonosono K
    • Journal Title

      Jpn J Ophthalmol 48

      Pages: 475-477

    • NAID

      80016936659

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Possibility of non-steroidal treatment in allergic conjunctival diseases2004

    • Author(s)
      Uchio E
    • Journal Title

      Allergol Int 53

      Pages: 315-319

    • NAID

      10014261217

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Predominance of infiltrating IL-4-producing T cells in conjunctiva of patients with allergic conjunctival diseases2004

    • Author(s)
      Matsuura N, Uchino E, Nakazawa M, Yago T, Matsumoto S, et al.
    • Journal Title

      Curr Eye Res 29

      Pages: 235-243

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two patients with severe corneal disease in KID syndrome2004

    • Author(s)
      Sonoda S, Uchino E, Sonoda KH, Yotsumoto S, Uchio E, Isashiki Y, Sakamoto T
    • Journal Title

      Am J Ophthalmol 137

      Pages: 181-183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Multicoated contact lens for bimanual vitreous surgery without endoillumination2004

    • Author(s)
      Kadonosono K, Yabuki K, Nishide T, Nomura E, Uchio E, Yamakawa T
    • Journal Title

      Arch Ophthalmol 122

      Pages: 367-368

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Predominance of infiltrating IL-4 producing T cells in conjunctiva of patients with allergic conjunctival disease2004

    • Author(s)
      Matsuura N, Uchio E, Nakazawa M, Yago T, Matsumoto S, Ohno S, Minami M
    • Journal Title

      Curr Eye Res 29

      Pages: 235-243

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Predominance of infiltrating IL-4 producing T cells in conjunctiva of patients with allergic conuctival disease2004

    • Author(s)
      Matsuura N, Uchio E, Nakazawa M, Yago T, Matsumoto S, et al.
    • Journal Title

      Current Eye Research 29

      Pages: 235-243

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Acute asthma attack caused by ophthalmic application of anti-allergic agents2004

    • Author(s)
      Uchio E, Kadonosono K
    • Journal Title

      Japanese Journal of Ophthalmology 48

      Pages: 475-477

    • NAID

      80016936659

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Simulation of airbag impact on eyes after photorefractive keratectomy by finite element analysis method2003

    • Author(s)
      Uchio E, Kadonosono K, Matsuoka Y, Goto S
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 241

      Pages: 497-504

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Measured visual acuity of fellow eyes as a prognostic factor in macular hole surgery2003

    • Author(s)
      Kadonosono K, Yabuki K, Nishide T, Uchio E, Marron JA
    • Journal Title

      Am J Ophthalmol 135

      Pages: 493-498

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 眼科プラクティス4巻 眼科所見の据え方と描き方「結膜異常所見と重症度分類」2005

    • Author(s)
      内尾英一
    • Total Pages
      365
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 眼科プラクティス4巻 眼科所見の捉え方と描き方「結膜異常所見と重症度分類」2005

    • Author(s)
      内尾英一
    • Total Pages
      365
    • Publisher
      文光堂
    • Related Report
      2005 Annual Research Report
  • [Publications] Uchio E, Watanabe Y, Kadonosono K, Matsuoka Y, Goto S: "Simulation of airbag impact on eyes after photorefractive keratectomy by finite element analysis method"J Cataract Refract Surg. 30. 483-490 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 山口健一, 伊藤由起,.門之園一明, 内尾英一: "Crystalline keratopathyを呈したCandida parapsilosisによる両眼性角膜真菌症と考えられる一例"横浜医学. 54. 41-45 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uchio E, Kadonosono K, Matsuoka Y, Goto S: "Simulation of airbag impact on eyes with transscleral-fixed posterior chamber intraocular lens by finite element analysis method"Graefes Arch Clin Exp Ophthalmol. 24. 497-504 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kadonosono K, Takeuchi S, Yabuki K, Yamakawa T, Mekada A, Uchio E: "Absorption of short wavelengths of endoillumination in indocyanine green solution : implications for internal limiting membrane removal"Graefes Arch Clin Exp Ophthalmol. 241. 284-286 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uchio E, Kadonosono K: "Acute asthma attack caused by ophthalmic application of anti-allergic agents"Jpn J Ophthalmol. (印刷中).

    • Related Report
      2003 Annual Research Report
  • [Publications] 加藤陽子, 小豆澤美香子, 伊藤由起, 西出忠之, 門之園一明, 内尾英一, 他: "横浜市大医療センターにおけるぶどう膜炎の統計"臨床眼科. (印刷中).

    • Related Report
      2003 Annual Research Report
  • [Publications] 内尾英一, 大野重昭: "喘息・アレルギー・リウマチ疾患治療薬ハンドブック,アレルギー性結膜炎"メディカルレビュー社. 442 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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