| Project/Area Number |
15591875
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
AWATA Takuya Saitama Medical University, Department of Medicine, Professor, 医学部, 教授 (40184303)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Keisuke Saitama Medical University, Department of Medicine, Associate Professor, 医学部, 助教授 (90251090)
OHKUBO Tomoko Saitama Medical University, Department of Medicine, instructor, 医学部, 助手 (40348214)
IIZUKA Hiroyuki Saitama Medical University, Department of Medicine, Instructor, 医学部, 助手 (20348246)
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| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | diabetic retinopathy / diabetic maculopathy / genetic factor / VEGF (vasucular endothelial growth factor) / eNOS / RAGE |
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| Research Abstract |
We have obtained the following results by candidate gene analyses of diabetic retinopathy and maculopathy. First, we have found that the C-634G polymorphism of the VEGF gene, which was found to be associated with diabetic retinopathy by us, is also associated with amyotrophic lateral sclerosis (ALS). Also, we have found that the C-634G is functionally significant, and that it is associated with diabetic macular edema (maculopathy) and correlated with macular thickness in type 2 diabetes. Furthermore, we have found that the T-786C and 27bp-repeat polymorphisms of the eNOS gene are associated with diabetic maculopathy, though it is not significantly associated with diabetic retinopathy.
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