| Project/Area Number |
15591881
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Aichi Medical University |
|---|
Principal Investigator |
ZAKO Masahiro Aichi Medical University, Department of Ophthalmology, Associate Prof., 医学部, 助教授 (80298596)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IWAKI Masayoshi Aichi Medical University, Department of Ophthalmology, Full Prof., 医学部, 教授 (10093163)
KIMATA Koji Aichi Medical University, Institute for Molecular Science of Medicine, Full Prof., 分子医科学研究所, 教授 (10022641)
YONEDA Masahiko Aichi Prefectural College of Nursing and Health, Associate Prof., 助教授 (80201086)
MIYAISHI Osamu Aichi Medical University, Associate Prof. (60229797)
|
|---|
| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥2,700,000 (Direct Cost: ¥2,700,000)
|
|---|
| Keywords | SPACR / SPACRCAN / Hyaluronan / Chondroitin Sulfate / Heparan Sulfate / Proteoglycan / ピアルロン酸 / コンドロイチン硫酸 / 視細胞外マトリックス / 網膜接着 / 網膜剥離 / ヘパリン |
|---|
| Research Abstract |
Except in mouse, hyaluronan is a prominent constituent of the interphotoreceptor matrix (IPM), where it may serve to organize the matrix by functioning as a basic scaffold to which other macromolecules in the insoluble IPM are attached. Interactions between SPACR, a hyaluronan binding protein, and hyaluronan serve to form the basic macromolecular scaffold, which comprises the insoluble IPM. We previously showed expression of SPACR increases with age, paralleling the adhesion between neural retina and retinal pigment epithelium, indicating that SPACR might be involved in a system that mediates adhesion between neural retina and retinal pigment epithelium. Associations between SPACRCAN, another hyaluronan binding protein, and hyaluronan are also involved m the organization of the insoluble IPM. We continue to investigate the mechanism of the occurrence of adhesion between neural retina and retinal pigment epithelium generated by SPACR and SPACRCAN in corporation with other glycosaminoglycans, such as hyaluronan, heparan sulfates, and chondroitin sulfates.
|
