| Project/Area Number |
15591887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Ehime University |
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Principal Investigator |
HORIUCHI Atsushi Ehime University, University Hospital, Instructor, 医学部附属病院, 助手 (10284407)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yuji Ehime University, University Hospital, Lecturer, 医学部附属病院, 講師 (20210958)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | hyperthermia / ablation / metallic magnetic materials / リポソーム |
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| Research Abstract |
This study aimed to put into practical use tumor ablation therapy employing induction heating that has been unavailable practically because it was difficult to develop a heating apparatus for practical use and there is no heating substance that meets the conditions of biocompatibility and sufficient hyperthermia. Application of induction heating to a MgFe_2O_4 needle, constructed to be placed in the tumor, elevated temperature to 131.3 ± 6.5℃ on average on the needle in dried conditions. Histologically, necrotic areas were limited to about 3 mm, but apoptotic lesions were found at the periphery and Hsp70 was expressed at further outside areas. A MgFe_2O_4 needle was placed in the rat subcutaneous tumor (average diameter, 17.6 mm) and induction heating was applied for 30 min. Temperature rose by 12.3±1.8℃ on the skin surface and 9.6±5.7℃ in the tumor on average, and a remarkable reduction in tumor size was found in 6 of 7 rats (85.7%). The size in liver tumor was also decreasesed in 5/6 rats (83.3%). Taken together, it was presumed that induction heating exerted antitumor effect with a reduction in tumor size, involving the effect other than direct necrotizing effect, since it necrotized relatively small areas.
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