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The time of acquired tolerance formation in liver transplantation, and elucidation and clinical application of participating bioacctive substance

Research Project

Project/Area Number 15591890
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionFUJITA HEALTH UNIVERSITY (2004)
Nagoya City University (2003)

Principal Investigator

HASHIMOTO Takashi  Fujita Health University, Medical School, Professor, 医学部, 教授 (10094393)

Co-Investigator(Kenkyū-buntansha) SUGIOKA Atsushi  Fujita Health University, Medical School, Associate Professor, 医学部, 助教授 (20171150)
鈴木 達也  名古屋市立大学, 大学院・医学研究科, 助手 (00285222)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsacquired tolerance / liver transplantation / cytokine / immunosuprression / protein / FK506 / 再灌流障害
Research Abstract

Hashimoto who was a main researcher started study in April 2004 in cooperation with assistant professor Atsushi Sugioka in Fujita Health University School of Medicine.
Assistant professor Sugioka elucidates from his previous study that acquired tolerance is derivate in an experimental liver transplantation using all assembly of mouse strains.
1. We started liver transplantation program in Fujita Health University from June 7 2004. Now, we have experienced 9 cases of living donor liver transplantation.
Although we lost a case of 23 year old female from thrombotic thrombocytopenic purpura, but remaining 8 cases are healthy, and acquired tolerance derivation is expected in 6 of child cases. Now we are investigating the lymphocyte cross matching and storing the serum samples with time.
2. Elucidation of an immunosuppression related humoral factors in a clinical liver transplantation
We initially planed to use a protein tip method to elucidate a new peptide. However, it becomes clear that SELDI … More protein tip needs a large amount of expense to examine one specimen. We then did not obtain a denovo data concerning this procedure except only past values until the present. For a purpose to compare immune status of cases without an immunosuppressive agent with other cases in follow up at the outpatient clinic, we choose and measure immunology coherence cytokines (IL-4, IL-8, IL-IL-10, IL-12) and are evaluating it.
3. A block of derivation of acquired tolerance by FK506
For an elucidation of a mechanism of acquired tolerance derivation easily after mouse liver transplantation, it will be useful to block the obtaining of tolerance. Professor Sugioka has proved that the acquired tolerance is concluded in any kind of assembly without administration of immunosuppressive agent on a liver transplantation of mouse. On the other hand, we know that acquired tolerance is delivered after sever rejection in early period of the post transplantation in this liver transplantation. Therefore, we gave FK506 (tacrolimus) which was effective immunosuppressive agent to clarify influence by preventing of initial rejection, to the candidate. Resulting of this treatment, we were able to prevent the rejection, but acquired tolerance derivation was blocked. Less

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (18 results)

All 2005 2004 Other

All Journal Article (14 results) Publications (4 results)

  • [Journal Article] 肝移植における拒絶反応の診断と治療2005

    • Author(s)
      日比 将人
    • Journal Title

      肝胆膵 50(1)

      Pages: 121-128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Clinical diagnosis and treatment of the rejection on liver transplantation2005

    • Author(s)
      Masahito Hibi, Takashi Hashimoto, Fujio Hara, Hirokazu Tomishige, Yoshihisa Nishida, Atsushi Sugioka, Takazumi Kato, Tetsushi Yoshikawa, Tatsuya Suzuki, Tanahashi Yoshinao, Tsukasa Nakamura
    • Journal Title

      KAN・TAN・SUI (Japan) 50(1)

      Pages: 121-128

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Liver Transplantation-associated Hypercalcemia Followed by Acute Renal Dysfunction2004

    • Author(s)
      Yuichi Shirasawa
    • Journal Title

      Internal Medicine 43(9)

      Pages: 802-806

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 特集 生体肝移植とその短期および長期成績 I.ドナー 1.左肝切除2004

    • Author(s)
      棚橋 義直
    • Journal Title

      外科 66(9)

      Pages: 993-998

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 特集 肝臓,小腸移植の最前線 肝移植術後管理の進歩2004

    • Author(s)
      加藤 充純
    • Journal Title

      小児外科 36(6)

      Pages: 737-743

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Postoperative Corticosteroid Therapy for Bile Drainage in Biliary Atresia-A Nationwide Survey2004

    • Author(s)
      Toshihiro Muraji
    • Journal Title

      Journal of Pediatric Surgery 39(12)

      Pages: 1803-1805

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] FK506 Inhibits Tolerance Induction in Mice Transplantation2004

    • Author(s)
      Atsushi Sugioka
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Liver Transplantation-associated Hypercalcemia Followed by Acute Renal Dysfunction2004

    • Author(s)
      Yuichi Shirasawa, Tomoyuki Nomura, Atsuhiro Yoshida, Takashi Hashimoto, Genjiro Kimra, Makoto Ito
    • Journal Title

      Internal Medicine 43(9)

      Pages: 802-806

    • NAID

      130000085088

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Long-term prognosis of left liver donor on the living donor liver transplantation2004

    • Author(s)
      Tanahashi Yoshinao, Takashi Hashimoto, Tatsuya Suzuki, Tomoshi Kondo, Yoko Sato, Tsukasa Nakamura, Yoshinori Nakamura, Yota Yamagishi, Masahito Hibi, Takazumi Kato, Atsushi Sugioka
    • Journal Title

      Surgery 66(9)

      Pages: 993-998

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Progress in diagnosis and treatment for postoperative rejection and or hepatitis in living donor liver transplantation2004

    • Author(s)
      Takazumi Kato, Takashi Hashimoto, Tatsuya Suzuki, Tanahashi Yoshinao, Tsukasa Nakamura, Masahito Hibi, Tomoshi Kondo, Yoko Sato
    • Journal Title

      Japanese Journal of Pediatric Surgery 36(6)

      Pages: 737-743

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Postoperative Corticosteroid Therapy for Bile Drainage in Biliary Atresia-A Nationwide Survey2004

    • Author(s)
      Toshihiro Muraji, Masaki Nio, Youkatsu Ohhama, Takashi Hashimoto, Tadashi Iwanaka, Hideo Takamatsu, Naomi Ohnuma, Tetsuo Kato, Ryoji Ohi
    • Journal Title

      Journal of Pediatric Surgery 39(12)

      Pages: 1803-1805

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 特集 生体肝移植とその短期および長期成績I.ドナー 1.左肝切除2004

    • Author(s)
      棚橋 義直
    • Journal Title

      外科 66(9)

      Pages: 993-998

    • Related Report
      2004 Annual Research Report
  • [Journal Article] FK506 inhibits Tolerance Induction in Mice Transplantation2004

    • Author(s)
      Atsushi Sugioka
    • Related Report
      2004 Annual Research Report
  • [Journal Article] FK506 Inhibits Tolerance Induction in Mice Transplantation

    • Author(s)
      Atsushi Sugioka, Miwa Morita, Takazumi Kato, Soujyun Hoshimoto, Jyunko Fujita, Zenichi Morise, Akitake Hasumi
    • Journal Title

      (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Tetsuya Ito: "Allopurinol challenge tests performed before and after living-related donor liver transplantation in citrullinaemia."J.Inherit.Metab.Dis.. 26. 87-88 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 橋本 俊: "第5回学術講演会「よく見かけられる小児外科疾患の診断と治療」"名古屋医報. 1260. 6-11 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 橋本 俊: "治療に難渋しているKasabach-Merritt症候群を呈する左前胸部巨大血管腫の1例"東京小児外科研究会. 31. 7-11 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 伊藤 嘉規: "生体肝移植症例におけるXE-2100を用いた破砕血球定量測定の検討"日本検査血液学会雑誌. 4・3. 384-390 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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