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Analysis of Cancer Gene Polymorphism Using Gigabit Internet

Research Project

Project/Area Number 15591933
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionOKAYAMA UNIVERSITY

Principal Investigator

KAWAHARA Kenji  Okayama University, Graduate School of Medicine and Dentistry, Oral Radiotology, Associate Professor, 大学院・医歯学総合研究科, 助教授 (50076113)

Co-Investigator(Kenkyū-buntansha) NAGAI Noriyuki  Okayama University, Graduate School of Medicine and Dentistry, Oral Pathology and medicine, Professor, 大学院・医歯学総合研究科, 教授 (90085770)
NAGATSUKA Hitoshi  Okayama University, Graduate School of Medicine and Dentistry, Oral Pathology and Medicine, Associate Professor, 大学院・医歯学総合研究科, 助教授 (70237535)
GUNDUZ Mehmet  Okayama University, Graduate School of Medicine and Dentistry, Oral Pathology and Medicine, Assistant, 大学院・医歯学総合研究科, 助手 (70333507)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsGigabit Network / Gene Analysis Information / Genome Seminar / Motion Image Live / lpv6 Protocol / ギガビット / JGN / インターネット / SNP / ゲノム
Research Abstract

In recent years, the advance in internet technology is indeed striking. On the other hand, analysis of polygenic diseases through single nucleotide polymorphisms (SNP) has been conducted on life-style related diseases (hypertension and diabetes) in the aging society and also for a changeover to order-made medical care. Aiming to analyze the massive individual data and to globalize the research technology, we have utilized charge-free network and internet lines and attempted to build a server by a data distribution system via TAO (Japan Giga Network : JGN) that has the largest lines in Japan.
As an experimental procedure of LIVE, we have obtained permission to connect to the gigabit network (TAO) under the jurisdiction of Ministry of Internal Affairs and Communication. Aiming to improve the motion image delivery and educational efficacy of the optical fiber 155 Mbps high-speed internet line installed in our faculty, the representative of this study previously conducted several tests of bi-directional motion image delivery (70 Mbps) with Okayama University of Science in Okayama City, which has the experience of connection with the TAO line.
This system was shown to be useful as server for the HP of curriculum transmission and TV conference.
1,The access point was planned for inside and outside Japan in English via the gigabit network center. The group visited the Dental School of Seoul University in Korea and confirmed that connection was possible on both sides.
2,Nagai who is the study representative in information output decided the details of the above-mentioned genome seminar and lectures by theme. Data analysis was conducted by Nagatsuka and Gunduz.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (25 results)

All 2004 2003 Other

All Journal Article (19 results) Publications (6 results)

  • [Journal Article] Characteritics of Melanosomes in Melanotic and Amelanotic Melanomas2004

    • Author(s)
      You-jin Lee
    • Journal Title

      J.of Hard Tissue Biology 13(2)

      Pages: 89-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of demethylating agent 5-aza-2(‘)-deoxycytidine and histone deacetylase inhibitor FR901228 on maspin gene expression in oral cell lines.2004

    • Author(s)
      Murakami J.
    • Journal Title

      Oral Oncol. 40(6)

      Pages: 597-603

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cyclin A correlates with the sensibility of human cancer cells to cytotoxic effects of 5-FU.2004

    • Author(s)
      Kawashima R.
    • Journal Title

      Int.J.Oncol. 24(2)

      Pages: 273-278

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Localization of heparanase in esophageal cancer cell : respective roles in prognosis and differentiation.2004

    • Author(s)
      Ohkawa T.
    • Journal Title

      Lab Invest. 84(10)

      Pages: 1289-1304

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Adjuvant targeted therapy with trastuzumab may decrease metastatic capacity in specific group of oropharyngeal cancer patients : downregulation of E-cadherin-catenin complex by cooperative effect of erbB-2 and human papillomavirus type 16 E6/E72004

    • Author(s)
      Altundag O.
    • Journal Title

      Protooncogenes 63(2)

      Pages: 277-280

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characteritics of Melanosomes in Melanotic and Amelanotic Melanomas2004

    • Author(s)
      You-jin Lee, Esra Gunduz, Ryo Tamamura, Shin Takagi, Kenji Kawahara, Kan Rui, Huang Bingzhen, Gul San Ara Sathi, Mahmoud Hashem Al Sheikh Ali, Noriyuki Nagaoka, Jing Xiao, Noriyuki Nagai
    • Journal Title

      J.of Hard Tissue Biology 13(2)

      Pages: 89-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of demethylating agent 5-aza-2(‘)-deoxycytidine and histone deacetylase inhibitor FR901228 on maspin gene expression in oral cell lines.2004

    • Author(s)
      Murakami J., Asaumi J., Maki Y., Tsujigiwa H., Kuroda M., Nagai N., Yanagi Y., Inoue T., Kawasaki S., Tanaka N., Matsubara N., Kishi K.
    • Journal Title

      Oral Oncol. 40(6)

      Pages: 597-603

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cyclin A correlates with the sensibility of human cancer cells to cytotoxic effects of 5-FU.2004

    • Author(s)
      Kawashima R., Haisa M., Kitamura M., Takaoka M., Shirakawa Y., Takeda H., Uetsuka H., Gunduz M., Nagai N., Tanaka N., Naomoto Y.
    • Journal Title

      Int.J.Oncol. 24(2)

      Pages: 273-278

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Localization of heparanase in esophageal cancer cell : respective roles in prognosis and differentiation.2004

    • Author(s)
      Ohkawa T., Naomoto Y., Takaoka M., Nobuhisa T., Noma K., Motoki T., Murata T., Uetsuka H., Kobayashi M., Shirakawa Y., Yamatsuji T., Matsubara N, Matsuoka J., Haisa M., Gunduz M., Tsujigiwa H., Nagatsuka H., Hosokawa M., Nakajima M., Tanaka N.
    • Journal Title

      Lab Invest. 84(10)

      Pages: 1289-1304

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Adjuvant targeted therapy with trastuzumab may decrease metastatic capacity in specific group of oropharyngeal cancer patients : downregulation of E-cadherin-catenin complex by cooperative effect of erbB-2 and human papillomavirus type 16 E6/E72004

    • Author(s)
      Altundag O., Altundag K., Morandi P., Gunduz M.
    • Journal Title

      Protooncogenes 63(2)

      Pages: 277-280

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of Notch in a case of osteosarcoma of the maxilla2004

    • Author(s)
      Kawakami T
    • Journal Title

      European Journal of Medical Research 9(11)

      Pages: 533-535

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of demethylating agent 5-aza-2(')-deoxycytidine and histone deacetylase inhibitor FR901228 on maspin gene expression in oral cancer cell lines2004

    • Author(s)
      Murakami J
    • Journal Title

      Oral Oncology 40(6)

      Pages: 597-603

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in rat osteoporosis induced by immunosuppressant FK5062004

    • Author(s)
      Fukunaga J
    • Journal Title

      Bone 34(3)

      Pages: 425-431

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cyclin A correlates with the sensitivity of human cancer cells to cytotoxic effests of 5-FU2004

    • Author(s)
      Kawashima R
    • Journal Title

      International Journal of Oncology 24(2)

      Pages: 273-278

    • Related Report
      2004 Annual Research Report
  • [Journal Article] In vitro response of osteoblast-like and odontoblast-like cells to unsubstituted and substituted apatites2004

    • Author(s)
      Inoue M
    • Journal Title

      Journal of Biomedical Materials Research 70A(4)

      Pages: 585-593

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Characteristics of Melanosomes in Melanotic and Amelanotic Melanomas2004

    • Author(s)
      You-jin-Lee
    • Journal Title

      Journal of Hard Tissue Biology 13(2)

      Pages: 89-92

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Collaboration of dental field with web radio and video live by mit21 group2003

    • Author(s)
      Kawahara Kenji
    • Journal Title

      the Quintessence 22(3)

      Pages: 642-647

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Influence for gigabite network of dental digitalization I2003

    • Author(s)
      Kawahara Kenji
    • Journal Title

      the Quintessence 22(11)

      Pages: 2496-2499

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Influence for gigabite network of dental digitalization II2003

    • Author(s)
      Kawahara Kenji
    • Journal Title

      the Quintessence 22(12)

      Pages: 2737-2740

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] 河原研二: "医療を変革させる歯科デジタル化でのネットワークの影響(I)"ザ・クインテッセンス. 22巻・11号. 2496-2499 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 河原研二: "医療を変革させる歯科デジタル化でのネットワークの影響(II)"ザ・クインテッセンス. 22巻・12号. 2737-2740 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kimura A: "Gene expression of type I collagen in neoplastic chondrocytes"European Journal Medical Research. 8(4). 165-167 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishizaki K: "Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering"American Journal of Otolaryngology. 24(1). 14-18 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Beder LB: "Abstract Genome-wide analyses on loss of heterozygosity in head and neck squamous cell carcinomas"Laboratory Investigation. 83(1). 99-105 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takaoka M: "Heparanase expression correlates with invasion and poor prognosis in gastric cancers"Laboratory Investigation. 83(5). 613-622 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2021-04-07  

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