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Study on alteration of expression of genes and proteins related to development, progression and characteristic morphogenesis of salivary gland tumors

Research Project

Project/Area Number 15591935
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

OGAWA Ikuko  Hiroshima University, Hospital, Assistant Professor, 病院, 講師 (70136092)

Co-Investigator(Kenkyū-buntansha) TAKATA Takashi  Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院医歯薬総合研究科, 教授 (10154783)
MIYAUCH Mutsumi  Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor, 大学院医歯薬総合研究科, 助教授 (50169265)
KUDO Yasusei  Hiroshima University, Graduate School of Biomedical Sciences, Research Associate, 大学院医歯薬総合研究科, 助手 (50314753)
佐藤 淳  広島大学, 医学部・医歯薬学総合研究科, 助手 (70335660)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsSalivary gland tumors / Cell adhesion molecules / Cell cycle regulating factors / Skp2 / Metaplasia / Immortalized cell / 細胞分裂制御因子 / p53 / p27 / oncocytic metaplasia / periostin / rRNA methylase / Aurora-A / Aurora-B / 細胞株化 / β-カテニン / 細胞株
Research Abstract

To accumulate the basic data useful to diagnosis, prediction and treatment of salivary gland tumors, we examined the alteration of gene and protein expression in various salivary gland tumors using tumor tissues and cell lines.
1. The expression of cell adhesion molecules such as E-cadherin, β-catenin and CD44v9 which are strongly expressed in epithelium of normal salivary gland, cell cycle regulatory factors such as p53, p27, cyclin D1 and Aurora A/B and epidermal growth factor receptor altered in salivary gland tumors, especially malignant tumors. In adenoid cystic carcinoma, Skp2 may play an important role in development and pregression through the down-regulation of p27. On the basis of these results, we will propose a new entity of low-grade malignant pleomorphic adenoma with mutation of p53 gene and down-regulation of p27 protein.
2. SAKI and periostin related to the development and/or progression of oral squamous cell carcinoma may be not associated with those of salivary gland tumors.
3. In the tumors with oncocytic metaplasia which causes the diagnostic difficulty in salivary gland tumors, the evaluation of differential markers including glandular epithelial and myoepitheial markers is important for the establishment of the diagnosis.
4. The immortalized pleomorphic adenoma cells showing the expression of glandular epithelial and myoepithelial markers were established by transfection with hTERT gene. These cells are useful for the analysis of characteristic morphogenesis of pleomorphic adenoma.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (19 results)

All 2007 2006 2005 2004 2003 Other

All Journal Article (18 results) Publications (1 results)

  • [Journal Article] Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid cystic carcinoma2007

    • Author(s)
      Keikhaee, M.R. et al.
    • Journal Title

      Virchows Archive (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid cystic carcinoma2007

    • Author(s)
      Keikhaee M.R. et al.
    • Journal Title

      Virchows Archive (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sclerosing polycystic adenosisと腫瘍、特に硬化性変化を伴う多形腺腫との鑑別が問題となった1症例2006

    • Author(s)
      小川, 郁子 他
    • Journal Title

      日本唾液腺学会誌 47

      Pages: 29-29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A case of sclerosing polycystic adenosis. Difficulty of differential diagnosis between reactive and neoplastic resions, especially pleomorphic adenoma with sclerosis (in Japanese)2006

    • Author(s)
      Ogawa I. et al.
    • Journal Title

      Journal of The Japan Salivary Gland Society 47

      Pages: 29-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 広範にpapillary-cysticな組織構築を示し、細胞異型の明瞭な領域を伴った耳下腺原発上皮-筋上皮性癌の1例2005

    • Author(s)
      小川, 郁子 他
    • Journal Title

      診断病理 22

      Pages: 231-234

    • NAID

      10016852708

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 嚢胞化を伴ったoncocytic carcinomaの1例2005

    • Author(s)
      小川, 郁子 他
    • Journal Title

      日本唾液腺学会誌 46

      Pages: 48-49

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 唾液腺腫瘍の分子病理2005

    • Author(s)
      小川, 郁子 他
    • Journal Title

      日本唾液腺学会誌 46

      Pages: 57-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Papillary-cysticな組織構築を広範に示した腺上皮-筋上皮性唾液腺腫瘍の2例2005

    • Author(s)
      小川, 郁子 他
    • Journal Title

      日本唾液腺学会誌 46

      Pages: 123-124

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A case of epithelial-myoepitherial carcinoma of the parotid gland showing predominantly papillary-cystic growth pattern with an area of cellular atypia (in Japanese)2005

    • Author(s)
      Ogawa I. et al.
    • Journal Title

      Japanese Journal of Diagnostic Pathology 22

      Pages: 231-234

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Oncocytic carcinoma with cystic structure (in Japanese)2005

    • Author(s)
      Ogawa I. et al.
    • Journal Title

      Journal of the Japan Salivary Gland Society 46

      Pages: 48-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular pathology of salivary gland tumors (in Japanese)2005

    • Author(s)
      Ogawa I. et al.
    • Journal Title

      Journal of The Japan Salivary Gland Society 46

      Pages: 57-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two cases of salivary gland tumors composed of epithelial-myoepithelial cells showing prominent papillary-cystic growth pattern (in Japanese)2005

    • Author(s)
      Ogawa I. et al.
    • Journal Title

      Journal of The Japan Salivary Gland Society 46

      Pages: 123-124

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 広範にpapillary-cysticな組織構築を示し,細胞異型の明瞭な領域を伴った耳下腺原発上皮-筋上皮性癌の1例2005

    • Author(s)
      小川 郁子
    • Journal Title

      診断病理 22・5

      Pages: 231-234

    • NAID

      10016852708

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 唾液腺腫瘍の分子病理2005

    • Author(s)
      小川 郁子
    • Journal Title

      日本唾液腺学会誌 46

      Pages: 57-68

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 細胞化を伴ったoncocytic carcinomaの1例2005

    • Author(s)
      小川 郁子
    • Journal Title

      日本唾液腺学会誌 46

      Pages: 48-49

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Papillary-cysticな組織構築を広範に示した腺上皮-筋上皮性唾液腺腫瘍の2例2004

    • Author(s)
      小川 郁子
    • Journal Title

      第49回日本唾液腺学会抄録集

      Pages: 34-35

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dedifferentiated malignant myoepithelioma of the parotid gland2003

    • Author(s)
      OGAWA, Ikuko et al.
    • Journal Title

      Pathology International 53

      Pages: 704-709

    • NAID

      50000346448

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dedifferentiated malignant myoepithelioma of the parotid gland2003

    • Author(s)
      Ogawa I. et al.
    • Journal Title

      Pathology International 53

      Pages: 704-709

    • NAID

      50000346448

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Ogawa, Ikuko: "Dedifferentiated malignant myoepithelioma of the parotid gland"Pathology International. 53. 704-709 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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