| Project/Area Number |
15591938
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
KIDO Mzuho A. Kyushu University, Faculty of Dental Science, Associate professor, 歯学研究院, 助教授 (60253457)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Teruo Kyushu University, Faculty of Dental Science, Professor, 歯学研究院, 教授 (60077667)
YAMAZA Takayoshi Kyushu University, Faculty of Dental Science, Research Associate, 歯学研究院, 助手 (80304814)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | capsaicin / VR1 / taste / pain / nerve / sensory / nociceptive / rat / VRI |
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| Research Abstract |
Capsaicin is a pungent substance in hot peppers evokes a tingling and burning sensation in oral cavity. Pungent sensation of hot peppers is thought to be mediated by TRPV1(transient receptor potential channel-vanilloid sub family member 1). However, little is known about the TRPV1 localization in the oral cavity. We demonstrated by immunohistochemistry that the taste papillae in the tongue were richly innervated by TRPV1-immunoreactive nerve fibers. Furthermore, TRPV1 protein expression was seen in the epithelium facing the oral cavity, although taste cells seemed to be devoid of TRPV1. The most conspicuous TRPV1 expression was observed in the epithelial cells of the palatal rugae. Under the electron microsopic observation TRPV1 immunoreactivity was found mostly in unmyelinated axons, and occasionally in thinly myelinated axons. The finding that TRPV11 is expressed not only in primary afferents, but also in oral epithelial cells, suggests that it is of great importance in the perception of capsaicin, heat, and acid in the mouth. Since TRPV1 is known to play a key role in nociception and inflammatory pain, it may be a new target for the treatment of oral pain
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