| Project/Area Number |
15591984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
SAKO Noritaka Asahi University, Sch.Dent., Dept.Oral Physiol., Associate Professor, 歯学部, 助教授 (90243154)
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| Co-Investigator(Kenkyū-buntansha) |
KATSUKAWA Hideo Asahi University, Sch.Dent., Dept.Oral Physiol., Research Associate, 歯学部, 助手 (00076051)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | conditioned food aversion / temperature of foods / hardness of foods / amygdala / Wistar rats / FOS蛋白 / ラット / 食物嫌悪条件づけ / 破壊実験 / 摂取溶液温度 / 食物の硬さ / 条件刺激 |
|---|
| Research Abstract |
It is known that taste can act as a conditioned stimulus (CS) for conditioned food aversion. In the present study, in order to examine whether or not the temperature and hardness of foods can be a CS, we conducted behavioral and neuroscientific experiments in Wistar rats. The results were follows : (1)The rats subjected to aversive conditioning to temperature of distilled water could learn to avoid these CSs, but they did not avoid any taste stimuli. (2)The rats subjected to aversive conditioning to hardness of foods also could learn to avoid these CSs. (3)The rats with bilateral lesions of amygdala could not acquire conditioning to temperature and hardness of the CS. (4)When the rats subjected to aversive conditioning to temperature of distilled water durunk CS,FOS proteins were expressed in their amygdala. These results suggest that rats can be conditioned to temperature and hardness of foods aversion and that amygdala plays an important role for this conditioning.
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