| Project/Area Number |
15592079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
KURATA Shigeaki Kanagawa Dental College, Department of Oral Medicine, Division of Biomaterials and Devices, Assistant Professor, 歯学部, 助教授 (20104333)
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| Co-Investigator(Kenkyū-buntansha) |
UMEMOTO Kozo Kanagawa Dental College, Department of Oral Medicine, Division of Biomaterials and Devices, Professor, 歯学部, 教授 (40097275)
二瓶 智太郎 神奈川歯科大学, 歯学部, 講師 (50237781)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Antibacterial activity / dental resin / Silver methacrylate / Silver ion |
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| Research Abstract |
There is the research of dental resin which made silver ion to be antibacterial substance until now. The silver ion is fixed to the carrier such as zeolite, the carrier is mixed with the resin, and the composite resin is made. The silver ion has not uniformly been dispersed in composite material, and in addition the toughness of the composite resin decrease.
The development of antibacterial dental resin using silver meyhacrylate monomer (MAg) as an antibacterial substance was tried. The solubility of MAg in methyl methacrylate (MMA) was examined, and then the mechanical property of the polymer obtained by polymerization of MAg-containing MMA was tested. As a results, MAg was dissolved to MMA in a concentration of 84×10^<-6> mol/l (about 9 ppm). And it was suggested that the concentration was enough for the appearance of antibacterial activity, because the smallest extinction concentration of silver ion for a Escherichia coil is 3〜13ppm. The Compressive and bending strength of the copolymer of MMA and 2-Methacryloyloxyethyltrimethyl ammonium chloride (MC) decreased with the content of MC. However MAg-containing resin obtained was transparent colorlessness, and there was no problem in esthetics. The compressive and bending strength of the resin were not significantly different compared with those of PMMA The silver ions in the resin does not dissolve into water. MAg-containing resin can be expected as an antibacterial dental resin.
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