| Project/Area Number |
15592094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
NITTA Yasutaka Tohoku University, Hospital, Research Associate, 病院, 助手 (80250794)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEBAYASHI Yuji Fukushima Medical University, School of Medicine, Lecturer, 医学部, 講師 (70321982)
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| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Cancer Chemotherapy / Drag resistance / Membrane Transporter / Oral Cancer / 癌化学療法 / 予後 / 膜輸送 / 扁平上皮癌 |
|---|
| Research Abstract |
First, the expression levels of the target molecules for cancer chemotherapy such as drug transporters (ATP7B, MRP,2), DNA repair molecules (XPG, XPF) and the targets for FU such as TP, DPD, TS were examined by RT-PCR and immunohistochemical analysis in oral cancer. The expression levels of TP and TS were different between primary and lymph node metastatic lesions among the examined molecules. Next, using the transfectants of TS or TP, the enhancement of the expression levels of these molecules were examined in murine models. Unfortunately, the enhancement of these molecules were not obtained.
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