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Changes in the Cerebral Oxygen Environment during Psychosedation Sedation : Evaluation using a Near-Infrared Oxygenation Monitor

Research Project

Project/Area Number 15592129
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionIwate Medical University

Principal Investigator

SHINOHE Yutaka  Iwate Medical University, School of Dentistry, Lecturer, 歯学部, 講師 (30347885)

Co-Investigator(Kenkyū-buntansha) JOH Shigeharu  Iwate Medical University, School of Dentistry, Professor, 歯学部, 教授 (20154411)
SATOH Masahito  Iwate Medical University, School of Dentistry, Associate professor, 歯学部, 助教授 (60215845)
SATOH Kenichi  Iwate Medical University, School of Dentistry, Lectuer, 歯学部, 講師 (90265174)
SAKAMOTO Nozomu  Iwate Medical University, School of Dentistry, Assistant, 歯学部, 助手 (70285641)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsNear-Infrared Oxygenation Monitor / Psychosedation / Cerebral Oxygen / clinical dentistry
Research Abstract

We investigated the change of the intracerebral oxygen environment during inhalation sedation with nitrous oxide(I) and intravenously injected with abirritants (Midazolam : MD- ; 0.03mg/kg,0.05mg/kg, 0.07mg/kg group, Propofol : PRF- ; 1〜3 mg/kg/hrgroup) (II) using a near-infrared oxygen monitor (NIRO).
Results
I. 1.In both groups, SBP, DBP and HR did not change significantly throughout the experiment.2. In both groups, ETCO_2 increased gradually and significantly by the room air inhalation after a mixed-gas inhalation and there was also a significant difference between the two groups.3. TCPO_2 showed a trend that decreases gradually by the room air inhalation after a mixed-gas inhalation but there was no significant difference between the tow groups.4. HbO_2 had a significant fall by room air inhalation after a mixed-gas inhalation in N2O group and there was also a significant difference between the two groups.5. Δ Cytaa3 did not change significantly throughout the experiment in both gro … More ups, and there was no significant difference between the two groups.
II. 1. ETCO_2 and TCPCO_2 increased gradually under administration. After administration was halted, ETCO_2 and TCPCO_2began to decrease promptly and recovered to the original status after 10 minutes. 2. SpO_2 and TCPO_2 decreased gradually under administration. 3. HbO_2 increased gradually from 5 to 17 minutes and then decreased gradually from 18 to 38 minutes. 4. Δ Cytaa3 did not change significantly throughout the experiment.
Conclusion
In conclusion, during and after nitrous oxide inhalation sedation and during and after intravenous sedation in clinical dentistry, although the oxygen content in blood fell, a satisfactory intracerebral oxygen environment was maintained.
Therefore, the results of this study suggest that the partial pressure of oxygen in arterial blood will not fall from change of SpO_2 and TcPO_2, but cerebral partial pressure of oxygen falls due to the significant fall of HbO2 following inhalation of the room air after 30% of nitrous oxide inhalation. However it is believed that hypoxia of cerebral tissue does not occur from the change of Δ Cytaa3. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report

Research Products

(4 results)

All 2005

All Journal Article (4 results)

  • [Journal Article] 笑気吸入鎮静時の脳内酸素環境の変化 -近赤外線酸素モニター(Near Infrared Oxygenation Monitor : NIRO)による検討-2005

    • Author(s)
      四戸 豊 他5名
    • Journal Title

      日本歯科麻酔学会雑誌 33?2

      Pages: 212-218

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Changes in the Cerebral Oxygen Environment during N_2O Inhalation Sedation : Evaluation using a Near-Infrared Oxygenation Monitor2005

    • Author(s)
      Yutaka SHINOHE
    • Journal Title

      Journal of Japanese Dental Socity of Anesthesiology 33(2)

      Pages: 212-218

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 笑気吸入鎮静時の脳内酸素環境の変化-近赤外線酸素モニター(Near Infrared Oxygenation Monitor : NIRO)による検討-2005

    • Author(s)
      四戸 豊 他5名
    • Journal Title

      日本歯科麻酔学会雑誌 33・2

      Pages: 212-218

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 笑気吸入鎮静時の脳内酸素環境の変化-近赤外線酸素モニター(Near Infrared Oxygenation Monitor : NIRO)による検討-2005

    • Author(s)
      四戸 豊 他5名
    • Journal Title

      日本歯科麻酔学会雑誌 33・2(未定)

    • Related Report
      2004 Annual Research Report

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Published: 2003-03-31   Modified: 2016-04-21  

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