| Project/Area Number |
15592140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
SHIBUTANI Koh Nihon University, School of Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (70130523)
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| Co-Investigator(Kenkyū-buntansha) |
UDA Akio Nihon University, School of Dentistry at Matsudo, Lecturer (Full-Time), 松戸歯学部, 講師 (30277470)
YAMAGUCHI Hidenori Nihon University, School of Dentistry at Matsudo, Lecturer (Full-Time), 松戸歯学部, 講師 (50220273)
SHIMOSAKA Michiharu Nihon University, School of Dentistry at Matsudo, Research Assistant (Full-Time), 松戸歯学部, 助手 (90297854)
SUZUKI Masatoshi Nihon University, School of Dentistry at Matsudo, Research Assistant (Full-Time), 松戸歯学部, 助手 (60366614)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2004: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2003: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | Bispectral Index / Target Control Infusion / intravenous sadation / propofol / amnestic effects / pre-medication / 覚醒刺激 / BIS / 全身麻酔 / 精神鎮静法 / 催眠レベル / 記憶 / 血中濃度 |
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| Research Abstract |
The Bispectral Index (BIS) monitor is used to assess anesthetic depth during anesthesia, and the present study investigated amnestic effects, estimated cerebral concentration of propofol (PPF), and BIS value following PPF administration by target control infusion.
[Experiment 1] As a basic experiment, the relationship between the BIS value during PPF administration and estimated cerebral concentration of PPF was investigated, which revealed that a correlation existed between the BIS value and estimated cerebral concentration. However, the assessment of consciousness and amenesia levels based on the BIS value proved impossible.
[Experiment 2] The amnestic effects of PPF during sedation induction and awakening were investigated. During the induction, amnestic effects were obtained at an estimated cerebral concentration of 0.91±0.21μg/ml, and during awakening, amnestic effects were obtained at an estimated cerebral concentration of 0.65±0.18μg/ml. Therefore, when under sedation, amnestic ef
… More
fects could be maintained at a lower concentration of PPF when compared to induction.
[Experiment 3] During awakening following PPF administration, the effects of awakening stimulation on BIS value and post-sedation amnestic effects were investigated. The results showed that there was a rapid increase in BIS value if awakening stimulation was actively delivered after PPF administration. When awakening stimulation was delivered, although the estimated cerebral concentration of PPF was high, amnestic effects were lost and memory was regained. However, the BIS value required for memory recovery ranged widely, and no consistent tendencies were observed.
[Experiment 4] In patients who were scheduled to undergo general anesthesia, in order to ascertain the effects of pre-medication on preoperative BIS value and memory, BIS value and amnestic effects were assessed upon the patient's entry in the operating room. The results showed significant differences in BIS value and amnestic effects among the different types of pre-medication. This suggests that the BIS monitor is also useful in assessing pre-medication. Less
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