Mechanisms of ectopic orofacial pain following peripheral nerve injury.
| Project/Area Number |
15592149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
TOKUNAGA Atsushi Hyogo College of Medicine, Associate Professor, 医学部, 助教授 (70254521)
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Koichi Hyogo College of Medicine, Professor, 医学部, 教授 (10212127)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | ectopic pain / trigeminal ganglion / extracellular signal-related kinase / nerve injury / immunohistochemistry / glia / rat / immunohistochemistry |
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| Research Abstract |
It has been reported that the injury of the 3rd branch of trigeminal nerve induced abnormal sensations in the area of the 2nd branch of trigeminal nerve. We hypothesized that the induction of the abnormal sensations were involved in the intra-ganglionic signaling via glial cells and satellite cells in the trigeminal ganglion. After transection of the inferior alveolar nerve, ED-1 positive cells were detected in through out of the trigeminal ganglion, not only around the ATF3 positive neurons. The induction of ED-1 positive cells was speculated to be mediated by cytokines such as TNFα, however, the induction of NF-κB was not detected. Furthermore, in order to investigate whether the activation of neurons in the 1st or 2nd branch of trigeminal ganglion could be induced, the phosphorylation of extracellular signal-related kinase(ERK) of the neurons was discussed. However, after the transection of inferior alveolar nerve, mechanical stimulation to the whisker pad by von Frey filaments did not induce the phosphorylated ERK in the trigeminal ganglion neurons.
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Report
(3 results)
Research Products
(18 results)
