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Is it possible to prevent cerebral apoplexy by periodontal therapy?

Research Project

Project/Area Number 15592194
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionKyushu Dental College

Principal Investigator

SONOKI Kazuo  Kyushu Dental College, Dentistry, Assistant, 歯学部, 助手 (50316155)

Co-Investigator(Kenkyū-buntansha) TAKATA Yutaka  Kyushu Dental College, Dentistry, Professor, 歯学部, 教授 (40163208)
YOKOTA Makoto  Kyushu Dental College, Dentistry, Professor, 歯学部, 教授 (40107298)
NAITO Toru  Fukuoka Dental College, Dentistry, lecturer, 歯学部, 講師 (10244782)
MURAOKA Kousuke  Kyushu Dental College, Dentistry, Assistant, 歯学部, 助手 (80382422)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Keywordsperiodontal disease / cerebral apoplexy / atherosclerosis / carotid artery ultrasonography / brain MRI / 頚動脈エコー検査
Research Abstract

To investigate the relationship between the periodontal disease and cerebral apoplexy by a prospective intervention examination, we did periodontal disease evaluation and carotid artery ultrasonography, brain MRI, fasting blood examination, and history taking, and then started a periodontal therapy in 2003.
In 2004 and 2005, we performed all these examinations as a reevaluation after a periodontal therapy again. From 2003 to 2004, total 16 patients were enrolled, and then four patients dropped out. We analyzed 12 patients' data of 3 points from 2003 to 2005 by Friedman test.
The number of the survival teeth decreased from 21.7 to 20.2 significantly. After one year, number of sites where the pocket depth (PD) was more than 6mm or 4mm, bleeding on probing (BOP), decreased significantly, and were preserved afterwards.
In fasting blood examination, white blood cell count decreased, Hb increased, and-γGTP improved. Maximal intima-media thickness (IMT) of right common carotid artery measured by ultrasonography, were related with number of sites of PD≧4mm, white blood cell count, red blood cell count, Hb, fasting blood glucose and HbA1c by single regression analysis. By multiple regression analysis of these factors, only HbA1c remained. In brain MRI, five people already accepted an atherosclerotic change at 2003, but one of them improved it one year later and did not change afterwards (improvement group). Four remainders were constant for two years (constant group). An atherosclerotic change appeared to two patients newly one year later and did not change afterwards (aggravation group). Since periodontal therapy was effective in both of improvement group and aggravation group, there seems to be not any relation between a change of brain MRI and periodontal therapy.
As a result, we were not able to find the apparent influence of a periodontal therapy on a change of cerebral examinations.

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (12 results)

All 2005 2004 Other

All Journal Article (9 results) Publications (3 results)

  • [Journal Article] Relationship of number of remaining teeth to health-related quality of life in community-dwelling elderly.2005

    • Author(s)
      Akifusa S, Sonoki K, et al.
    • Journal Title

      Gerodontology 22(1)

      Pages: 91-97

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tooth loss associated with abnormal electrocardiographic findings in octogenarians.2005

    • Author(s)
      Takata Y, Sonoki K, et al.
    • Journal Title

      J Kyushu Dent Soc 59(4)

      Pages: 153-160

    • NAID

      110006420801

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Relationship of number of remaining teeth to health-related quality of life in community-dwelling elderly.2005

    • Author(s)
      Akifusa S, Sonoki K, et al.
    • Journal Title

      Gerodontology 22

      Pages: 91-97

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Tooth loss associated with abnormal electrocardiographic findings in octogenarians.2005

    • Author(s)
      Takata Y, Sonoki K, et al.
    • Journal Title

      J Kyushu Dent Soc 59

      Pages: 153-160

    • NAID

      110006420801

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Relationship of number of remaining teeth to health-related quality of life in community-dwelling elderly.2005

    • Author(s)
      Akifusa S, Takata Y Sonoki K, et al.
    • Journal Title

      Gerodontology 22(1)

      Pages: 91-97

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Relationship of physical fitness to chewing in 80-year-olds.2004

    • Author(s)
      Takata Y, Sonoki K, et al.
    • Journal Title

      Oral Diseases 10・1

      Pages: 44-49

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Relationship between hepatitis virus infection and dental status in an 80-year-old population.2004

    • Author(s)
      Takata Y, Sonoki K, et al.
    • Journal Title

      J Disability Oral Health 5・2

      Pages: 65-69

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Activities of daily living and chewing ability in an 80-year-old population.2004

    • Author(s)
      Takata Y, Sonoki K, et al.
    • Journal Title

      Oral Diseases 10・6

      Pages: 365-368

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association of QT interval with blood pressure in 80-year-old subjects.2004

    • Author(s)
      Matsumura K, Sonoki K, et al.
    • Journal Title

      Hypertension Research 27・6

      Pages: 387-391

    • Related Report
      2004 Annual Research Report
  • [Publications] Sonoki K, et al.: "Atherogenic role of lysophosphatidylcholine in low-density lipoprotein modified by phospholipase A2 and in diabetic patients"Metabolism. 52. 308-314 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takata Y, et al., Sonoki K.: "Prevalence of hepatitis viral infection in dental patients with impacted teeth or jaw deformities"Oral Surgery Oral Medicine Oral Pathology Oral Radiology Endodontics. 96(1). 26-31 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takata Y, et al., Sonoki K.: "Relation of physical fitness to chewing in 80-year-olds."Oral Diseases. 10(1). 44-49 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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