| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Research Abstract |
The authors planned two studies to provide of dysgeusia experienced by patients receiving cancer chemotherapy. The studies are : 1.It is to identify effects of lymphoma patients' chemotherapy on dysgeusia and physiological and psychological reaction of saliva secretion and to dysgeusia their relationship. 2.Effects of gargling with soda water containing 10% lemon for cancer chemotherapy patients with dysgeusia.
Eight patients hospitalized with malignant lymphoma and on therapies including CHOP who agreed to participate in the study were surveyed The taste thresholds (saltiness, sourness, sweetness, and bitterness), saliva production, nursing observation of saliva secretion serum zinc and serum Zn/Cu ratio, OAG (Oral Assessment Guide) score and subjective evaluation to taste disturbance were examined on the day before chemotherapy, and 4th, 8th, and 12th days afterwards.
1.The saliva secretion the fourth day during chemotherapy was significantly lower than before chemotherapy (P<0.05).
2.On the other hand, the taste thresholds, serum zinc, serum Zn/Cu ratio and OAG score were within the normal range, and a remarkable change was not seen from the day before chemotherapy to 12th day afterwards.
3.For subjective evaluation of salivary gland change in 4^<th> day two subjects reported "sticky or thick".
4.The saliva secretion was significantly higher (p<0.01) after gargling with Soda Water Containing Lemo. Taste threshold test of five steps was not corresponding after gargling with Soda Water Containing Lemo.
5.There was relationship observed in the subjective evaluation of taste disturbance and the amount of saliva secretion.
It was qualitatively demonstrated that saliva secretion reduced on the fourth day of chemotherapy. Since decline in saliva production is said to cause dysguesia, we would like to continue studying with more subjects. The relationship between the two will help us develop effective nursing plan for the patients with dysguesia.
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