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Effects of the Physiological Responses on Gargling with Soda Water Containing Lemon for Cancer Chemotherapy Patients with Dysgeusia.

Research Project

Project/Area Number 15592254
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical nursing
Research InstitutionGunma University

Principal Investigator

KANDA Kiyoko  Gunma University, School of Health Sciences, Professor, 医学部, 教授 (40134291)

Co-Investigator(Kenkyū-buntansha) KANO Tro  Gunma University, School of Health Sciences, Assistant, 医学部, 助手 (30312896)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsCancer Patient / Cancer Chemotherapy / Dysgeusia / Taste threshold / Saliva secretion / lemon water / Soda water / Gargling
Research Abstract

The authors planned two studies to provide of dysgeusia experienced by patients receiving cancer chemotherapy. The studies are : 1.It is to identify effects of lymphoma patients' chemotherapy on dysgeusia and physiological and psychological reaction of saliva secretion and to dysgeusia their relationship. 2.Effects of gargling with soda water containing 10% lemon for cancer chemotherapy patients with dysgeusia.
Eight patients hospitalized with malignant lymphoma and on therapies including CHOP who agreed to participate in the study were surveyed The taste thresholds (saltiness, sourness, sweetness, and bitterness), saliva production, nursing observation of saliva secretion serum zinc and serum Zn/Cu ratio, OAG (Oral Assessment Guide) score and subjective evaluation to taste disturbance were examined on the day before chemotherapy, and 4th, 8th, and 12th days afterwards.
1.The saliva secretion the fourth day during chemotherapy was significantly lower than before chemotherapy (P<0.05).
2.On the other hand, the taste thresholds, serum zinc, serum Zn/Cu ratio and OAG score were within the normal range, and a remarkable change was not seen from the day before chemotherapy to 12th day afterwards.
3.For subjective evaluation of salivary gland change in 4^<th> day two subjects reported "sticky or thick".
4.The saliva secretion was significantly higher (p<0.01) after gargling with Soda Water Containing Lemo. Taste threshold test of five steps was not corresponding after gargling with Soda Water Containing Lemo.
5.There was relationship observed in the subjective evaluation of taste disturbance and the amount of saliva secretion.
It was qualitatively demonstrated that saliva secretion reduced on the fourth day of chemotherapy. Since decline in saliva production is said to cause dysguesia, we would like to continue studying with more subjects. The relationship between the two will help us develop effective nursing plan for the patients with dysguesia.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (12 results)

All 2004 Other

All Journal Article (10 results) Publications (2 results)

  • [Journal Article] DYSGEUSIA AND PHYSIOLOGICAL AND PSYCHOLOGICAL REACTION OF MALIGNANT LYMPHOMA PATIRENTS AFTER CHEMOTHERAPY2004

    • Author(s)
      Kiyoko Kanda, Taro Kano
    • Journal Title

      13^<th> International Conference on Cancer Nursing(Sydeney, Australia) Abstract Book

      Pages: 117-117

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical and physiological investigations of CHOP therapy induce taste disturbance2004

    • Author(s)
      Taro Kano, Kiyoko Kanda
    • Journal Title

      13^<th> International Conference on Cancer Nursing(Sydeney, Australia) Abstract Book

      Pages: 118-118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 感覚障害ケアのエビデンス:味覚2004

    • Author(s)
      神田清子
    • Journal Title

      臨床看護 29(13)

      Pages: 2012-2021

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] レモン水洗口が唾液分泌および味覚閾値に及ぼす影響2004

    • Author(s)
      狩野太郎, 大沼ひとみ, 野田清子
    • Journal Title

      日本生理人類学会誌 9(2)

      Pages: 31-37

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DYSGEUSIA AND PHYSIOLOGICAL AND PSYCHOLOGICAL REACTION OF MALIGNANT LYMPHOMA PATIRENTS AFTER CHEMOTHERAPY2004

    • Author(s)
      Kiyoko Kanda, Taro Kano
    • Journal Title

      13^<th> International Conference on Cancer Nursing (Sydney, Australia), Abstract Book

      Pages: 117-117

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical and physiological investigations of CHOP therapy induce Taste disturbance2004

    • Author(s)
      Taro Kano, Kiyoko Kanda
    • Journal Title

      13^<th> International Conference on Cancer Nursing (Sydney, Australia), Abstract Book

      Pages: 118-118

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Evidence Care of Taste Disturbance2004

    • Author(s)
      Kiyoko Kanda
    • Journal Title

      Journal of Clinical Nursing Vol.29(13)

      Pages: 2012-2021

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of Rinsing the Mouth with Lemon-Flavored Water on Saliva Secretion and Taste Threshold2004

    • Author(s)
      Taro KANO, Hitomi Ohnuma, Kiyoko Kanda
    • Journal Title

      Japanese Journal of Physiological Anthropology Vol.9(2)

      Pages: 31-37

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DYSGEUSIA AND PHYSIOLOGICAL AND PSYCHOLOGICAL REACTION OF MALIGNANT LYMPHOMA PATIRENTS AFTER CHEMOTHERAPY2004

    • Author(s)
      Kiyoko Kanda, Taro Kano
    • Journal Title

      13^<th> International Conference on Cancer Nursing(Sydney, Australia) (Abstract Book)

      Pages: 117-117

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Clinical and physiological investigations of CHOP therapy induce taste disturbance2004

    • Author(s)
      Taro Kano, Kiyoko Kanda
    • Journal Title

      13^<th> International Conference on Cancer Nursing(Sydney, Australia) (Abstract Book)

      Pages: 118-118

    • Related Report
      2004 Annual Research Report
  • [Publications] 神田清子, 狩野太郎: "DYSGEUSIA AND PHYSIOLOGICAL AND PSYCHOLOGICAL REACTION OF MALIGNANT LYMPHOMA PATIRENTS AFTER CHEMOTHERAPY"13^<th> International Conference on Cancer Nursing (Sydney, Australia). (発表予定). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 神田清子, 狩野太郎: "Clinical and physiological investigations of CHOP therapyinduce taste disturbance"13^<th> International Conference on Cancer Nursing (Sydney, Australia). (発表予定). (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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