脳卒中発症に関わる遺伝・環境要因相互作用の解明

• Project/Area Number: 15790293
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Public health/Health science
• Research Institution: Tohoku University
• Principal Investigator: 大久保 孝義 東北大学, 大学院・薬学研究科, 助教授 (60344652)
• Project Period (FY): 2003 – 2005
• Project Status: Completed (Fiscal Year 2005)
• Budget Amount: ¥3,400,000 (Direct Cost: ¥3,400,000); Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 脳卒中 / 高血圧 / 遺伝要因 / 環境要因 / 家庭血圧 / 自由行動下血圧 / コホート研究 / 臨床疫学 / 遺伝子要因

Research Abstract

一般住民の代表サンプル2000人に対し、24時間自由行動下血圧および家庭血圧測定を実施し、コホート研究により脳卒中発症リスクとの関連及び種々の遺伝・環境要因に関する検討を行った。
1.家庭血圧・24時間血圧と脳卒中発症リスクとの関連について
(1)仮面高血圧の脳卒中リスクは高いが白衣高血圧のリスクは低いことを明らかにした。
(2)夜間血圧下降度減は脳梗塞の、モーニングサージは脳出血のそれぞれリスクとなっていることを明らかにした。
2.遺伝要因と脳卒中発症危険因子との関連について
(1)β1アドレナリン受容体Gly389Arg多型と家庭血圧値および心拍数との関連について検討し、Argアリル保有群で血圧・心拍数が高値であることを発見した。
(2)Urocortin3のR91G多型が白衣効果(随時血圧と家庭血圧値)と関連していることを発見した。
(3)Interleukin10遺伝子多型(-592A/C)が寿命と関連している可能性を明らかにした。
(4)Regulator of G protein signaling-2遺伝子A/G多型が高血圧発症と関連していることを明らかにした。
3.環境要因と脳卒中発症危険因子との関連について
(1)運動不足・喫煙が家庭高心拍の要因であることを明らかにした。
(2)肥満・白衣高血圧が家庭高血圧発症のリスクであることを明らかにした。

Research Products

• [Journal Article] Is interleukin-10 promoter polymorphism associated with life-span? : The Ohasama Study (2006)
  • Author(s): Ogimoto A, Ohkubo T, et al.
  • Journal Title: Circulation Journal 70(S1) Pages: 404-404
• [Journal Article] Prognostic significance for stroke of a morning pressor surge and a nocturnal blood pressure decline : the Ohasama study. (2006)
  • Author(s): Metoki H, Ohkubo T, et al.
  • Journal Title: Hypertension 47 Pages: 149-154
• [Journal Article] Beta 1 adrenoceptor gene polymorphisms increase the risk for hypertension and modulate the cardiovascular tonus : The Ohasama Study (2005)
  • Author(s): Katsuya T, Ohkubo T, et al.
  • Journal Title: Journal of Hypertension 23(S2) Pages: 245-245
• [Journal Article] Urocortin III polymorphism is associated with blood pressure. (2005)
  • Author(s): Totsune K, Ohkubo T, et al.
  • Journal Title: Journal of the American Society of Nephrology 16
• [Journal Article] Prognosis of "masked" hypertension and "white-coat" hypertension detected by 24-h ambulatory blood pressure monitoring 10-year follow-up from the Ohasama study. (2005)
  • Author(s): Ohkubo T, et al.
  • Journal Title: Journal of the American College of Cardiology 46 Pages: 508-515
• [Journal Article] Factors affecting home-measured resting heart rate in the general population : the Ohasama study. (2005)
  • Author(s): Yamaguchi J, Ohkubo T, et al.
  • Journal Title: American Journal of Hypertension 18 Pages: 1218-1225
• [Journal Article] Association between Angiotensin II Type 1 Receptor Gene Polymorphism and Essential Hypertension : the Ohasama Study. (2004)
  • Author(s): Sugimoto K, et al.
  • Journal Title: Hypertension Research 27 Pages: 551-556
• [Journal Article] Association of Beta-1-adrenergic Receptor Gene Polymorphism with Cardiovascular Function in Japanese Population : the Ohasama Study. (2004)
  • Author(s): Katsuya T, et al.
  • Journal Title: Circulation Journal 68 Pages: 130-131
• [Journal Article] New Candidate of Genetic Predisposing Factor for Essential Hypertension : Japanese Millenium Project and The Ohasama Study. (2004)
  • Author(s): Katsuya T, et al.
  • Journal Title: Circulation 110 Pages: 827-827
• [Journal Article] How many times should blood pressure be measured at home for better prediction of stroke risk? : 10-year follow-up results from the Ohasama study. (2004)
  • Author(s): Ohkubo T, et al.
  • Journal Title: Journal of Hypertension 22 Pages: 1099-1104
• [Journal Article] Prediction of ischaemic and haemorrhagic stroke by self-measured blood pressure at home : the Ohasama study (2004)
  • Author(s): Ohkubo T, et al.
  • Journal Title: Blood Pressure Monitoring 9 Pages: 315-320
• [Journal Article] Prediction of stroke by self-measurement of blood pressure at home versus casual screening blood pressure measurement in relation to the Joint National Committee 7 classification : the Ohasama study. (2004)
  • Author(s): Asayama K, et al.
  • Journal Title: Stroke 35 Pages: 2356-2361
• [Publications] Ohkubo T, et al.: "How many times should blood pressure be measured at home for better prediction of stroke risk? 10-year follow-up results from the Ohasama study."Journal of Hypertension. (in press). (2004)
• [Publications] Asayama K, et al.: "Prodiction of stroke by home versus screening blood pressure measurements in relation to JNC-VII classification : the Ohasama study"Proceeding of the 1st World Congress of Chronobiology. 145 (2003)
• [Publications] Katsuya T, et al.: "Genetic risk factors for cerebral infarction using a large scale genetic epidemiological study: the Ohasama Study."Geriatrics & Gerontology International. 3. 150-153 (2003)
• [Publications] Fu Y, et al.: "Association of beta1-adrenergic receptor gene polymorphism with cardiovascular function in Japanese population : the Ohasama Study."Circulation Journal. (in press). (2004)