マヌカハニー摂取による大腸がん予防機構の解明に向けたニュートリオミクス研究

• Project/Area Number: 15F15395
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 外国
• Research Field: Food science
• Research Institution: Keio University
• Principal Investigator: 冨田 勝 慶應義塾大学, 環境情報学部(藤沢), 教授 (60227626)
• Co-Investigator(Kenkyū-buntansha): AW WANPING 慶應義塾大学, 環境情報学部(藤沢), 外国人特別研究員 ; AW Wanping 慶應義塾大学, 環境情報学部, 外国人特別研究員
• Project Period (FY): 2015-11-09 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,300,000 (Direct Cost: ¥2,300,000); Fiscal Year 2017: ¥200,000 (Direct Cost: ¥200,000); Fiscal Year 2016: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2015: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: Rice Bran / Gut microbiota / Metabolome / Metagenome / Multi-omics / DSS colitis / AOM DSS colon cancer / Manuka Honey

Outline of Annual Research Achievements

In this year, we conducted a screening experiment using different food products (Manuka Honey, Rice Bran and Soy Beans) in the animal models that we have created in last year.Unfortunately, Manuka Homey and Soy Beans supplementation did not improve colitis. As such, we aimed to elucidate the molecular mechanisms of Oryza sativa, rice bran(RB) dietrary intervention on 2.0% dextran sulfate sodium (DSS)-included colitis C57BL/6L mice mode. Body weight loss, disease activity index, colon length and colon histopathology were improved in BR-fed mice. Time-course microbiome and metabolome results suggest that RB-related alterations of gut environment can prevent colitis via establishing gut homeostasis. Our approach is an important tool in developing new therapeutic applications of RB.

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Eggshell membrane powder ameliorates intestinal inflammation by facilitating the restitution of epithelial injury and alleviating microbial dysbiosis (2017)
  • Author(s): Huijuan Jia, Manaka Hanate, Wanping Aw, Hideomi Itoh, Kenji Saito, Shoko Kobayashi, Satoshi Hachimura, Shinji Fukuda,Masaru Tomita, Yukio Hasebe, and Hisanori Kato.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 43993-43993
  • DOI: 10.1038/srep43993
  • Peer Reviewed / Open Access
• [Journal Article] Understanding the role of the gut ecosystem in Diabetes Mellitus (2017)
  • Author(s): Wanping Aw, Shinji Fukuda
  • Journal Title: Journal of Diabetes Investigation Volume: 印刷中 Issue: 1 Pages: 5-12
  • DOI: 10.1111/jdi.12673
  • Peer Reviewed / Open Access
• [Journal Article] The application of omics technologies in the functional evaluation of inulin and inulin-containing prebiotics dietary supplementation (2015)
  • Author(s): M Tsurumaki, M Kotake, M Iwasaki, M Saito, K Tanaka, W Aw, S Fukuda and M Tomita
  • Journal Title: Nutrition & Diabetes Volume: 5 Issue: 11 Pages: e185-e185
  • DOI: 10.1038/nutd.2015.35
  • Peer Reviewed / Open Access
• [Journal Article] An Integrated Outlook on the Metagenome and Metabolome of Intestinal Diseases (2015)
  • Author(s): W Aw and S Fukuda
  • Journal Title: Diseases Volume: 3 Issue: 4 Pages: 341-359
  • DOI: 10.3390/diseases3040341
  • Peer Reviewed / Open Access