• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of a novel analysis system for three-dimentional structure of transmembrane receptors based on neuronal and vascular cell plasticity

Research Project

Project/Area Number 15GS0312
Research Category

Grant-in-Aid for Creative Scientific Research

Allocation TypeSingle-year Grants
Research InstitutionOsaka University

Principal Investigator

SOBUE Kenji  Osaka University, Faculty of Medicine, Professor (20112047)

Co-Investigator(Kenkyū-buntansha) INUI Makoto  Yamaguchi University, Graduate School of Medicine, Professor (70223237)
HAYASHI Kenichiro  Osaka University, Graduate School of Medicine, Associate Professor (90238105)
MORITA Tsuyoshi  Osaka University, Graduate School of Medicine, Assistant Professor (80403195)
MAYANAGI Taira  Osaka University, Graduate School of Medicine, Specially Appointed Assistant Professor (20432544)
柴田 克志  大阪大学, 医学系研究科, 助手 (70296565)
今野 大治郎  大阪大学, 医学系研究科, 助手 (00362715)
Project Period (FY) 2003 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥595,530,000 (Direct Cost: ¥458,100,000、Indirect Cost: ¥137,430,000)
Fiscal Year 2007: ¥127,010,000 (Direct Cost: ¥97,700,000、Indirect Cost: ¥29,310,000)
Fiscal Year 2006: ¥120,250,000 (Direct Cost: ¥92,500,000、Indirect Cost: ¥27,750,000)
Fiscal Year 2005: ¥121,030,000 (Direct Cost: ¥93,100,000、Indirect Cost: ¥27,930,000)
Fiscal Year 2004: ¥114,270,000 (Direct Cost: ¥87,900,000、Indirect Cost: ¥26,370,000)
Fiscal Year 2003: ¥112,970,000 (Direct Cost: ¥86,900,000、Indirect Cost: ¥26,070,000)
Keywordsstructure biology / synapse / postsvnantic density(PSD) / dopamine receptor / atherosclerosis / vascular smooth muscle cell / LPA receptor / G protein-coupled receptor(GPCR) / 膜貫通型受容体 / GPCR / ドーパミンD1レセプター / PSD蛋白質 / 膜クラスター / LPAレセプター / 膜ターゲティング / G蛋白質共役型受容体(GPCR) / ミリスチン酸化 / 膜蛋白質クラスター / PSD-Zip45 / 神経前駆細胞 / フーリエ変換 / 可塑性 / X線構造解 / G蛋白質共役型受容体 / X線構造解析 / 膜ターゲッティング
Research Abstract

Transmembrane receptors including a superfamily of G protein-coupled receptors (GPCRs) are essential for all aspects of cell function and also play critical roles for the pathology of a number of diseases. With several exceptions, the three-dimensional ultra-structure of these receptors has not been demonstrated due to the difficultly of their purification in large quantity and their crystallization. In this project, we were developing a novel system for analyzing the three-dimensional ultra-structure of transmembrane receptors. In this system, two-dimensional dusters of transmembrane receptors at paracrystal levels are made in the cell membrane of lived cells by clustering the target receptors through a potently self multimerizable postsynaptic scaffolding protein, PSD-Zip45 (Homer 1c). In order to form a highly ordered two-dimensional transmembrane receptor clusters, we made a drastic modification of PSD-Zip45 (modified PSD-Zip45). As a result, this modified PSD-Zip45 was able to for … More m large clusters of dopamine receptor (a typical example of GPCRs) with a diameter of 3-8 um in the cell membrane of lived cells. We then established the purification method for dopamine receptor dusters with a high quality and large quantity. The fourier transformation of electronmicrographs of dopamine receptor duster preparations revealed a high quality at paracrystal levels. This system can be applied to a vast majority of transmembrane receptors. Actually, we also made two-dimensional large dusters of LPA receptor (another example of GPCRs) using our system. Thus, we provide a powerful system for analyzing the structure-function relationship of the transmembrane receptors. For the sake of conventional use, we are now going to try the scale-down of cell culture system for purifying two-dimensional dusters of transmembrane receptors.
In addition to the above project, we further demonstrated the molecular mechanisms underlying neuronal and vascular cell plasticity such as synaptic dynamics mediated by PSD proteins (PSD-Zip45, PSD-Zip70 and others) and onset of atherosclerosis triggered by unsaturated lysophosphatidic adds. Less

Report

(6 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (194 results)

All 2008 2007 2006 2005 2004 2003 Other

All Journal Article (105 results) (of which Peer Reviewed: 35 results) Presentation (73 results) Book (8 results) Publications (8 results)

  • [Journal Article] Rho/ROCK signal regulates myogenicdifferentiation via MRTF-A/Smad-dependent transcription of the Id3 gene2008

    • Author(s)
      Iwasaki K., et. al.
    • Journal Title

      J.Biol.Chem. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Rho/ROCK signal regulates myogenic differenti-ation via MRTF-A/Smad-dependent transcription of the Id3 gene.2008

    • Author(s)
      Iwasaki, K., et. al.
    • Journal Title

      J. Biol. Chem. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Rho/ROCK signal regulates myogenicdifferentiation via MRTF-A/Smad-dependent transcription of the Id3 gene2008

    • Author(s)
      Iwasaki K., et. al.
    • Journal Title

      J. Biol. Chem. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling.2008

    • Author(s)
      Morita T., et. al.
    • Journal Title

      J. Cell Biol. 179

      Pages: 1027-1042

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual roles of myocardin-related transcription factors in epithelial mesen chymal transition via slug induction and actin remodeling2007

    • Author(s)
      Morita T., et. al.
    • Journal Title

      J.Cell Biol. 179

      Pages: 1027-1042

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs)2007

    • Author(s)
      Morita T., et. al.
    • Journal Title

      Ex.Cell Res. 313

      Pages: 3432-3445

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation2007

    • Author(s)
      Yoshio T., et. al.
    • Journal Title

      FEBS Lett 581

      Pages: 3777-3782

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation2007

    • Author(s)
      Morita T., et. al.
    • Journal Title

      J.Biol.Chem 282

      Pages: 8454-8463

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Correlation of proliferative and anti-apoptotic effects of HGF,insulin,IGF-1,IGF-2,and EGF in SV40-transformed human corneal epithelial cells2007

    • Author(s)
      Matuura K, et. al.
    • Journal Title

      Eur.J.Pharmacol. 563

      Pages: 83-88

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] '医学のあゆみ2007

    • Author(s)
      林謙 一郎、祖父江 憲治
    • Journal Title

      医歯薬出版

      Pages: 1108-1112

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] '生体の科学2007

    • Author(s)
      祖父江 憲治、福本 健太郎
    • Journal Title

      医学書院

      Pages: 81-87

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dual roles of MRTFs in epithelial-mesenchymal transition via slug induction and actin remodeling.2007

    • Author(s)
      Morita, T., et. al.
    • Journal Title

      J. Cell Biol. 179

      Pages: 1027-1042

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Reorganization of the actin cytoskeleton via transcription regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors(MRTFs/MAL/1VIKLs).2007

    • Author(s)
      Morita, T., et. al.
    • Journal Title

      Exp. Cell Res. 313

      Pages: 3432-3445

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation.2007

    • Author(s)
      Yoshio, T., et. al.
    • Journal Title

      FEBS Lett. 581

      Pages: 3777-3782

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Changes in the balance between caldesmon regulated by PAKs and the Arp2/3 complex govern podosome formation.2007

    • Author(s)
      Morita, T., et. al.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 8454-8463

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Promotion of skin epithelial cell migration and wound healing by a 2-benzazepine derivative.2007

    • Author(s)
      Matsuura, K., et. al.
    • Journal Title

      Eur. J. Pharmacol. 563

      Pages: 83-88

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] BMP-regulating transcription factor, Msx-vascular calcification.2007

    • Author(s)
      Hayashi, K., et. al.
    • Journal Title

      Ishiyakushupan

      Pages: 1108-1112

    • NAID

      40015746226

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Roles of vascular smooth muscle cells in vascular remodeling.2007

    • Author(s)
      Hayashi, K., et. al.
    • Journal Title

      Ishiyakushupan

      Pages: 1150-1155

    • NAID

      40015424004

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Overview of protein constituting the postsynaptic density.2007

    • Author(s)
      Sobue, K., et. al.
    • Journal Title

      Igaku Shoin

      Pages: 81-87

    • NAID

      40015437536

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation.2007

    • Author(s)
      Morita T., et. al.
    • Journal Title

      J. Biol. Chem 282

      Pages: 8454-8463

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs).2007

    • Author(s)
      Morita T., et. al.
    • Journal Title

      Ex. Cell Res. 313

      Pages: 3432-3445

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caldesmon suppresses cancer cell invasion by regulating podosome/invad opodium formation2007

    • Author(s)
      Yoshio T., et. al.
    • Journal Title

      FEBS Lett. 581

      Pages: 3777-3782

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of proliferative and anti-apoptotic effects of HGF, insulin, IGF-1, IGF-2, and EGF in SV40-transformed human corneal epithelial cells2007

    • Author(s)
      Matuura K, et. al.
    • Journal Title

      Eur. J. Pharmacol. 563

      Pages: 83-88

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the balance between caldesmon rehulated PAKs and the Arp2/3 complex govern podosome formation.2007

    • Author(s)
      Morita T. et al.
    • Journal Title

      J.Biol.Chem. in press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Promotion of skin epithelial cell migration and wound healing by a 2-benzazepine derivative.2007

    • Author(s)
      Matuura K. et al.
    • Journal Title

      Eur.J.Pharmacol. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription2006

    • Author(s)
      Hayashi K., et. al.
    • Journal Title

      Mol.Cell Biol. 26

      Pages: 9456-9470

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differential control of postsynaptic density scaffolds via actin-dependent and-independent mechanisms2006

    • Author(s)
      Kuriu T., et. al.
    • Journal Title

      J.Neurosci. 26

      Pages: 7693-7706

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] ProSAP-interacting protein 1(ProSAPiP1),a novel protein of the postsynaptic density that links the spine-associated Rap-Gap(SPAR) to the scaffolding protein ProSAP2/Shank32006

    • Author(s)
      Wendholt D., et. al.
    • Journal Title

      J.Biol.Chem. 281

      Pages: 13805-13816

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Promotion of corneal epithelial wound healing by a tetrapeptide(SSSR) derived from IGF-12006

    • Author(s)
      Yamada N., et. al.
    • Journal Title

      Invest.Ophthalmol.Vis.Sci. 47

      Pages: 3286-3292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Correlation of proliferative and anti-apoptotic effects of HGF,insulin,IGF-1,IGF-2,and EGF in SV40-transformed human corneal epithelial cells2006

    • Author(s)
      Yanai R., et. al.
    • Journal Title

      Exp.Eye Res. 83

      Pages: 76-83

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PDZRN3(LNX3,SEMCAP3)is required for the differentiation of C2C12 myoblasts into myotubes2006

    • Author(s)
      Ko J.A., et. al.
    • Journal Title

      J.Cell Sci. 119

      Pages: 5106-5113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bone mophogenetic P-induced Msxl and Msx2 inhibit myocardin-dependent smooth muscle gene transcription.2006

    • Author(s)
      Hayashi, K., et. al.
    • Journal Title

      Mol. Cell. Biol. 26

      Pages: 9456-9470

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differential control of postsynaptic density scaffolds via actin-dependent and-independent mechanisms.2006

    • Author(s)
      Kuriu, T., et. al.
    • Journal Title

      J. Neurosci. 26

      Pages: 7693-7706

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ProSAPiP1, a novel PSD protein that links SPAR to the PDZ domain of ProSAP2/Shank3.2006

    • Author(s)
      Wendholt D., et. al.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 13805-13816

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Promotion of corneal epithelial wound healing by a tetrapeptide(SSSR) derived from IGF-1.2006

    • Author(s)
      Yamada, N., et. al.
    • Journal Title

      Invest. Ophthalmol. Vis. Sci. 47

      Pages: 3286-3292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Correlation of proliferative and anti-apoptotic effects of HGF, insulin, IGF-1, IGF-2, and EGF in SV40-transformed human corneal epithelial cells2006

    • Author(s)
      Yanai, R., et. al.
    • Journal Title

      Exp. Eye Res. 83

      Pages: 76-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PDZRN3(LNX3, SEMCAP3) is required for the differentiation of C2C12 myoblasts into myotubes.2006

    • Author(s)
      Ko, J.-A., et. al.
    • Journal Title

      J. Cell Sci. 119

      Pages: 5106-5113

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differential control of postsynaptic density scaffolds via actin-dependent and-independent mechanisms.2006

    • Author(s)
      Kuriu T. et al.
    • Journal Title

      J.Neurosci. 26・29

      Pages: 7693-7706

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bone mophogenetic P-induced Msx1 and Msx2 inhibit myocardependent smooth muscle gene transcription.2006

    • Author(s)
      Hayashi K. et al.
    • Journal Title

      Mol.Cell.Biol. 26・24

      Pages: 9456-9470

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ProSAPiPl, a novel PSD protein that links SPAR to PDZ domain of ProSAP2/Shank3.2006

    • Author(s)
      Wendholt D. et al.
    • Journal Title

      J.Biol.Chem. 281・19

      Pages: 13805-13816

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PDZRN3 (LNX3, SEMCAP3) is required for the differentiation of C2C12 myoblasts into mytubes.2006

    • Author(s)
      KoJA, et al.
    • Journal Title

      J.Cell Sci. 119・24

      Pages: 5106-51113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Correlation of proliferative and anti-apoptotic effects of HGF, insulin, IGF-1, IGF-2, and EGF in SV40-transformed human corneal epithelial cells.2006

    • Author(s)
      Yanai R. et al.
    • Journal Title

      Exp.Eye Res. 83・1

      Pages: 76-83

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Promotion of corneal epithelial wound healing by a tetrapeptide (SSSR) derived from IGF-1.2006

    • Author(s)
      Yamada N. et al.
    • Journal Title

      Invest. Ophthalmol. Vis. Sci. 47・8

      Pages: 3286-3292

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Promotion of corneal epithelial wound healing by a tetrapeptide (SSSR) derive from IGF-I.2006

    • Author(s)
      Yamada N. et al.
    • Journal Title

      Invest. Ophthalmol. Vis. Sci. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ProSAP interacting protein 1(ProSAPiP1), a novel protein of the postsynaptic density that links the spine associated Rap Gap (SPAR) to the scaffolding protein ProSAP2/Shank32006

    • Author(s)
      Wendholt D. et al.
    • Journal Title

      J. Biol. Chem. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Determination of absolute numbers in single synapses by a GFP-based calibration technique2005

    • Author(s)
      Sugiyama Y., et. al.
    • Journal Title

      Nature Methods 2

      Pages: 677-684

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] NMDA receptor-dependent synaptic translocation of IRSp53 via PKC signaling2005

    • Author(s)
      Hori K., et. al.
    • Journal Title

      J.Neurosci. 25

      Pages: 2670-2681

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dendritic spine maturity involves PSD-Zip70 in collaboration with its binding partner SPAR2005

    • Author(s)
      Maruoka H., et. al.
    • Journal Title

      J.Neurosci. 25

      Pages: 1421-1430

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Involved of the PI3-kinase/Rac1 and Cdc42 pathways in radial migration of cortical neurons2005

    • Author(s)
      Konno D., et. al.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 5082-5088

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Sensitizing effect of substance P on corneal epithelial migration induced by IGF-1,fibronectin,or interleukin-62005

    • Author(s)
      Yamada, N., et. al.
    • Journal Title

      Invest.Ophthalmol.Vis.Sci. 46

      Pages: 833-839

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Requirement of the transmembrane semaphorin Sema4C for myogenic differentiation2005

    • Author(s)
      Ko, J.-A., et. al.
    • Journal Title

      FEBS Lett 579

      Pages: 2236-2242

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of phospholipids on the oligomeric state of phospholamban of cardiac sarcoplasmic reticulum2005

    • Author(s)
      Zhang, X.-M., et. al.
    • Journal Title

      Circ.J. 69

      Pages: 1116-1123

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Homozygous mutation (L527R) of TGFβI in an individual with lattice corneal dystrophy2005

    • Author(s)
      Yamada, N., et. al.
    • Journal Title

      Br.J.Ophthalmol 89

      Pages: 771-773

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] '血管医学2005

    • Author(s)
      森田 強、祖父江 憲治
    • Journal Title

      メディカルレビュー社

      Pages: 45-53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Determination of absolute numbers in single synapses by a GFP-based calibration technique.2005

    • Author(s)
      Sugiyama, Y., et. al.
    • Journal Title

      Nature Methods 2

      Pages: 677-684

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] NMDA receptor-dependent synaptic translocation of IRSp53 via PKC signaling.2005

    • Author(s)
      Hori, K., et. al.
    • Journal Title

      J. Neurosci. 25

      Pages: 2670-2681

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dendritic spine maturity involves PSD-Zip70 in collaboration with its binding partner ; SPAR.2005

    • Author(s)
      Maruoka, H., et. al.
    • Journal Title

      J. Neurosci. 25

      Pages: 1421-1430

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Involved of the PI3-kinase/Racl and Cdc42 path-ways in radial migration of cortical neurons.2005

    • Author(s)
      Konno, D., et. al.
    • Journal Title

      J. Biol. Chem. 280

      Pages: 5082-5088

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Sensitizing effect of substance P on corneal epithelial migration induced by IGF-1, fibronectin, or interleukin-6.2005

    • Author(s)
      Yamada, N., et. al.
    • Journal Title

      Invest. Ophthalmol. Vis. Sci. 46

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Requirement of the transmembrane semaphorin sema4C for myogenic differentiation.2005

    • Author(s)
      Ko, J.-A., et. al.
    • Journal Title

      FEBS Lett. 579

      Pages: 2236-2242

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of phospholipids on the oligomeric state of phospholamban of cardiac sarcoplasmic reticulum.2005

    • Author(s)
      Zhang, X.-M., et. al.
    • Journal Title

      Circ. J. 69

      Pages: 1116-1123

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Homozygous mutation(L527R) of TGFBI in an individual with lattice corneal dystrophy.2005

    • Author(s)
      Yamada, N., et. al.
    • Journal Title

      Br. J. Ophthalmol. 89

      Pages: 771-773

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Vascular remodeling induced by lysophosphatidic acids.2005

    • Author(s)
      Morita, T., et. al.
    • Journal Title

      Medical Review sha

      Pages: 45-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Determination of absolute protein numbers in single synapses by a GFP-based calibration technique.2005

    • Author(s)
      Sugiyama Y. et al.
    • Journal Title

      Nature Methods 2・9

      Pages: 677-684

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of phospholipids on the oligomeric state of phospholamban of the cardiac sarcoplasmic reticulum.2005

    • Author(s)
      Zhang X.-M et al.
    • Journal Title

      Circ. J. 69・9

      Pages: 1116-1123

    • Related Report
      2005 Annual Research Report
  • [Journal Article] NMDA receptor-dependent synaptic translocation of insulin receptor substrate p53 via protein kinase C signaling2005

    • Author(s)
      Hori K.et al.
    • Journal Title

      J.Neurosci. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dynamic subpopulation of postsynaptic density molecules is critically dependent on actin cytoskeleton2005

    • Author(s)
      Kuriu T. et al.
    • Journal Title

      Neuron (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Determination of absolute numbers of postsynaptic molecules in single hippocampal excitatory synapses2005

    • Author(s)
      Sugiyama Y. et al.
    • Journal Title

      Neuron (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Requirement of the transmembrane semaphorin Sema4C for myogenic differentiation2005

    • Author(s)
      Ko J-A., et al.
    • Journal Title

      FEBS Lett. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Homozygous mutation (L527R) of TGFβ1 in an individual with lattice corneal dystrophy2005

    • Author(s)
      Yamada N. et al.
    • Journal Title

      Br.J.Ophthalmol. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Collaboration of PSD-Zip70 with its binding partner, SPAR, in dendrtic Spine maturity2005

    • Author(s)
      Maruoka H. et al.
    • Journal Title

      J.Neurosci. 25・6

      Pages: 1421-1430

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Involvement of the phosphatidylinositol 3-kinase/rac1 and cdc42 pathways in radial migration of cortical neurons2005

    • Author(s)
      Konno D. et al.
    • Journal Title

      J.Biol.Chem. 280・6

      Pages: 5082-5088

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sensitizing effect of substance P on corneal epithelial migration induced by IGF-1, fibronectin, or interleukin-62005

    • Author(s)
      Yamada N. et al.
    • Journal Title

      Invest.Ophthalmol.Vis.Sci. 46・3

      Pages: 833-839

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Insulin receptor substrate-1/SHP-2 interaction,a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells2004

    • Author(s)
      Hayashi K., et. al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 40807-40818

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of the C domain of IGFs in the synergistic promotion with a substance P-derived peptide of rabbit corneal epithelial wound healing2004

    • Author(s)
      Yamada N., et. al.
    • Journal Title

      Invest.Ophthalmol.Vis.Sci. 45

      Pages: 1125-1131

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differential modulation of NR1-NR2A and NR1-NR2B subtypes of NMDA receptor by PDZ domain-containing proteins2004

    • Author(s)
      Iwamoto, T., et. al.
    • Journal Title

      J.Neurochem. 89

      Pages: 100-108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Atherosclerosis XIII2004

    • Author(s)
      Sobue, K., et. al.
    • Journal Title

      Elsevier

      Pages: 103-106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells.2004

    • Author(s)
      Hayashi, K., et. al.
    • Journal Title

      J. Biol Chem. 279

      Pages: 40807-40818

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of the C domain of IGFs in the synergistic promotion with a substance P-derived peptide of rabbit corneal epithelial wound healing.2004

    • Author(s)
      Yamada, N., et. al.
    • Journal Title

      Invest. Ophthalmol. Vis. Sci. 45

      Pages: 1125-1131

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differential modulation of NR1-NR2A and NR1-NR2B subtypes of NMDA receptor by PDZ domain-containing proteins.2004

    • Author(s)
      Iwamoto, T., et. al.
    • Journal Title

      J. Neurochem. 89

      Pages: 100-108

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Signal transduction regulating the vascular smooth muscle phenotype and early molecular events of athrognesis.2004

    • Author(s)
      Sobue, K., et. al.
    • Journal Title

      In Atherosclerosis XIII.Elsevier

      Pages: 103-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells2004

    • Author(s)
      Hayashi K. et al.
    • Journal Title

      J.Biol.Chem. 279・39

      Pages: 40807-40818

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Differential modulation of NR1-NR2B subtypes of NMDA receptor by PDZ domain-containing proteins2004

    • Author(s)
      Iwamoto T et al.
    • Journal Title

      J.Neurochem. 89・1

      Pages: 100-108

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Role of the C domain of IGFs in the synergistic promotion with a substance P-derived peptide of rabbit corneal epithelial wound healing2004

    • Author(s)
      Yamada N. et al.
    • Journal Title

      Invest.Ophthalmol.Vis.Sci. 45・4

      Pages: 1125-1131

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Signal transduction regulating the vascular smooth muscle phenotype and early molecular events of atherogenesis2004

    • Author(s)
      Sobue K. et al.
    • Journal Title

      International Congress Series 1262

      Pages: 103-106

    • Related Report
      2004 Annual Research Report
  • [Journal Article] MALS is a binding partner of IRSp53 at cell-cell contacts2003

    • Author(s)
      Hori, K., et. al.
    • Journal Title

      FEBS Lett 554

      Pages: 30-34

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo2003

    • Author(s)
      Yoshida, K., et. al.
    • Journal Title

      Circulation 108

      Pages: 1746-1752

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Epiregulin as a major autocrine/paracrine factor released from the ERK-and p38MAPK-activated vascular smooth muscle cells2003

    • Author(s)
      Takahashi M., et. al.
    • Journal Title

      Circulation 108

      Pages: 2524-2529

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synchronized formation and remodeling of postsynaptic densities;long-term visualization of hippocampal neurons expressing postsynaptic density proteins tagged with green fluorescent protein2003

    • Author(s)
      Ebihara T., et. al.
    • Journal Title

      J.Neurosci. 23

      Pages: 2170-2181

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Calcineurin-mediated pathway involved in the differentiated phenotype of smooth muscle cells2003

    • Author(s)
      Ohkawa Y., et. al.
    • Journal Title

      Biochem Biophys Res Commun 301

      Pages: 78-83

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synaptic targeting of PSD-Zip45(Homer 1c)and its involvement in the synaptic accumulation of F-actin2003

    • Author(s)
      Usui S., et. al.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 10619-10628

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 病理と臨床2003

    • Author(s)
      祖父江 憲治
    • Journal Title

      文光堂

      Pages: 374-391

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] MALS is a binding partner of IRSp53 at cell-cell contacts.2003

    • Author(s)
      Hori, K., et. al.
    • Journal Title

      FEBS Lett. 554

      Pages: 30-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo.2003

    • Author(s)
      Yoshida, K., et. al.
    • Journal Title

      Circulation 108

      Pages: 1746-1752

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Epiregulin as a major autocrine/paracrine fac-tor released from the ERK-and p38MAPK-activated vascular smooth muscle cells.2003

    • Author(s)
      Takahashi M., et. al.
    • Journal Title

      Circulation 108

      Pages: 2524-2529

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synchronized formation and remodeling of post-synaptic densities : long-term visualization of hippocampal neurons expressing postsynaptic density proteins tagged with green fluorescent protein.2003

    • Author(s)
      Ebihara, T., et. al.
    • Journal Title

      J. Neurosci. 23

      Pages: 2170-2181

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Calcineurin-mediated pathway involved in the differentiated phenotype of smooth muscle cells.2003

    • Author(s)
      Ohkawa, Y., et. al.
    • Journal Title

      Biochem Biophys Res Commun. 301

      Pages: 78-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synaptic targeting of PSD-Zip45(Homer 1c) and its involvement in the synaptic accumulation of Factin.2003

    • Author(s)
      Usui, S.
    • Journal Title

      J. Biol. Chem. 278

      Pages: 10619-10628

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hypothesis of myofibroblastosis2003

    • Author(s)
      Sobue K.
    • Journal Title

      Bunkodo

      Pages: 374-491

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] MALS is a binding partner of IRSp53 at cell-cell contacts2003

    • Author(s)
      Hori K.et al.
    • Journal Title

      FEBS Lett. 554・1-2

      Pages: 30-34

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells2003

    • Author(s)
      Takahashi M. et al.
    • Journal Title

      Circulation 108・20

      Pages: 2524-2529

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo2003

    • Author(s)
      Yoshida K. et al.
    • Journal Title

      Circulation 108・14

      Pages: 1746-1752

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Synchronized formation and remodeling of postsynaptic densities : long-term visualization of hippo-camapal neurons expressing postsynaptic density proteins tagged with green fluorescent protein2003

    • Author(s)
      Epihara T. et al.
    • Journal Title

      J.Neurosci. 23・6

      Pages: 2170-2181

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Calcineurin-mediated pathway involved in the differentiated phenotype of smooth muscle cells2003

    • Author(s)
      Ohokawa Y. et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 301・1

      Pages: 78-83

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin2003

    • Author(s)
      Usui S.et al.
    • Journal Title

      J.Biol.Chem. 278・12

      Pages: 10619-10628

    • Related Report
      2004 Annual Research Report
  • [Presentation] 精神疾患、細胞骨格からのアプローチ2007

    • Author(s)
      祖父江憲治
    • Organizer
      第16回海馬と高次脳機能学会
    • Place of Presentation
      奈良市
    • Year and Date
      2007-11-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] 先端医療に向けた脳研究アプローチ2007

    • Author(s)
      祖父江 憲治, 他
    • Organizer
      第19回日本脳循環代謝学会総会
    • Place of Presentation
      盛岡市
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Myocardin-related transcription factors (MARFs) によるアクチン細胞骨格制御2007

    • Author(s)
      森田 強、真 柳平、祖父江 憲治
    • Organizer
      第30回日本分子生物学会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] グルココルチコイドによるCaldesmonの発現誘導を介した細胞形態・運動の制御2007

    • Author(s)
      真柳 平, 他
    • Organizer
      第30回日本分子生物学会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 先進医療に向けた脳研究アプローチ2007

    • Author(s)
      祖父江 憲治
    • Organizer
      第19回日本脳代謝学会大会
    • Place of Presentation
      盛岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細胞骨格から精神疾患へのアプローチ2007

    • Author(s)
      祖父江 憲治
    • Organizer
      海馬と高次脳機能学会
    • Place of Presentation
      奈良
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] caldesmonによるpodosome/invadopodium形成制御を介した癌細胞浸潤能の制御機2007

    • Author(s)
      森田 強、由雄 敏之、祖父江 憲治
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ホメオドメイン転写因子(Msx1,Msx2)による平滑筋特異的転写の阻害機構2007

    • Author(s)
      中村 誠志、林 謙一郎、祖父江 憲治
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨格筋細胞分化におけるRno/ROCKシグナルの二面性:筋芽細胞に対する正の制御と分化細胞に対する負の制御2007

    • Author(s)
      岩崎 一洋、林 謙一郎、祖父江 憲治
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism of atherosclerosis2007

    • Author(s)
      Kenji Sobue, Kenichiro Hayashi
    • Organizer
      The 5th US/Japan Workshop on Molecular and Cellular Aspects of Vascular Smooth Muscle Function
    • Place of Presentation
      Kona,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in the balance between caldesmon regulated by PAKs and the Arp2/3 complex govern podosome/invadopodium formation2007

    • Author(s)
      Tsuyoshi Morita, Taira Mayangi, Kenji Sobue
    • Organizer
      The 5th US/Japan Workshop on Molecular and Cellular Aspects of Vascular Smooth Muscle Function
    • Place of Presentation
      Kona,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PSD-95 modulates the sensitivity of NR1/NR2A subtype NMDA receptor channels for a NMDA receptor antagonist,MK8012007

    • Author(s)
      山田 康枝、乾 誠
    • Organizer
      第50回日本神経化学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PSD-95 modulates the sensitivity of NR1/NR2A subtype NMDA receptor channels for a NMDA receptor antagonist2007

    • Author(s)
      山田 康枝、乾 誠
    • Organizer
      第80回日本薬理学会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A 2-benzazepine derivative promotes akin epithelial cell migration and wound healing2007

    • Author(s)
      松浦 健, 他
    • Organizer
      第80回日本薬理学会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Modulation of NR1/NR2A-subtype NMDA receptor channels by SAP1022007

    • Author(s)
      山田 康枝、乾 誠
    • Organizer
      第79回日本薬理学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Reorganization of the actincytoskeleton by myocardin-related transcription factors.2007

    • Author(s)
      Morita, T., et. al.
    • Organizer
      The 30th Annual Meeting of the Molecular Biology Society of Japan, The 80th Annual Meeting of the Japanese Biochemical Society.
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Glucocorticoid regulates cell morphology and motiolity via caldesmon induction.2007

    • Author(s)
      Mayanagi, T., et. al.
    • Organizer
      The 30th Annual Meeting of the Molecular Biology Society of Japan, The 80th Annual Meeting of the Japanese Biochemical Society.
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A new approach for psychiatric disorders based on the cytoskeleton2007

    • Author(s)
      Sobue, K.
    • Organizer
      The 19th Annual of the Japanese Society of Cerebral Blood Flow and metabolism.
    • Place of Presentation
      Morioka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A new approach for recent advanced medicine based on cell biology2007

    • Author(s)
      Sobue, K.
    • Organizer
      Conference on the Hippocampus and high Neurons Activity.
    • Place of Presentation
      Nara
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular and Molecular mechanism of atherosclerosis.2007

    • Author(s)
      Sobue, K., Hayashi, K.
    • Organizer
      The 5th US/Japan Workshop on Cellular Aspects of Vascular Smooth Muscle Function
    • Place of Presentation
      Kona, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in the balance between caldesmon regulated by PAKs and the Arp2/3 complex goven podosome/invadopodium formation.2007

    • Author(s)
      Morita, T., et. al.
    • Organizer
      The 5th US/Japan Workshop on Cellular Aspects of Vascular Smooth Muscle Function
    • Place of Presentation
      Kona, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PSD-95 modulates the sensitivity of NR1/NR2A subtype NMDA receptor channels for a NMDA receptor antagonist, MK801.2007

    • Author(s)
      Yamada, Y., et. al.
    • Organizer
      The 50th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PSD-95 modulates the sensitivity of NR1/NR2A subtype NMDA receptor channels for a NMDA receptor antagonist, MK801.2007

    • Author(s)
      Yamada, Y., et. al.
    • Organizer
      The 80th Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A 2-benzazepine derivative promotes skin epithelial cell migration and wound healing.2007

    • Author(s)
      Matsuura, K., et. al.
    • Organizer
      The 80th Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 2-ベンズアゼピン誘導体による皮膚創傷治癒促進作用2006

    • Author(s)
      松浦 健, 他
    • Organizer
      第59回日本薬理学会西南部会
    • Place of Presentation
      那覇
    • Year and Date
      2006-11-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A 2-benzazepine derivative promotes skin wound healing2006

    • Author(s)
      Matsuura, K., et. al.
    • Organizer
      The 55th Annual Meeting of the Japanese Pharmacological Society Southwestern Section
    • Place of Presentation
      Naha
    • Year and Date
      2006-11-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Modulation of the channel activity of NR1/NR2A- and NR1/Nr2B-subtype NMDA receptors by SAP1022006

    • Author(s)
      山田 康枝、乾 誠
    • Organizer
      第49回日本神経化学会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-09-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Modulation of the channel activity of NR1/NR2A-and NR1/Nr2B-subtype NMDA receptors by SAP102.2006

    • Author(s)
      Yamada, Y., et. al.
    • Organizer
      The 49th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-09-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Modulation of NR1/NR2A-subtype NMDA receptor channels by SAP1022006

    • Author(s)
      Yamada, Y., Inui, M.
    • Organizer
      The 79th Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Caldesmon represses an oncogenic phenotype of RSV-transformed 3Y1 cells2005

    • Author(s)
      森田 強, 他
    • Organizer
      第78回日本生化学会大会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism involving IGF-I signal during myogenic differentiation2005

    • Author(s)
      岩崎 一洋, 林謙 一郎, 祖父江 憲治
    • Organizer
      第78回日本生化学会大会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Collabolation of PSD-Zip70 with SPAR in dendritic spines2005

    • Author(s)
      丸岡 久人, 他
    • Organizer
      第78回日本生化学会大会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interaction between Grinl and protein 4.1 in dendritic spines2005

    • Author(s)
      間藤 光一, 他
    • Organizer
      第78回日本生化学会大会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transcriptional regulation of SMC marker genes by Msx homeoprotein family2005

    • Author(s)
      林謙 一郎, 祖父江 憲治
    • Organizer
      第78回日本生化学会大会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Age-and region-dependent changes in expression of nestin in aortic smooth muscle cells2005

    • Author(s)
      及川 浩樹, 他
    • Organizer
      第78回日本生化学会大会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] スパインにおけるGRIN1と4.1N蛋白質の局在2005

    • Author(s)
      問藤 光一、吉田 智之、祖父江 憲治
    • Organizer
      第28回日本神経科学学会大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細胞骨格から先進医療に向けたアプローチ2005

    • Author(s)
      祖父江 憲治
    • Organizer
      日本老年泌尿器科学会
    • Place of Presentation
      盛岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The transmembrane semaphoring Sema4C is required for myoblast differentiation2005

    • Author(s)
      高知 愛, 他
    • Organizer
      第78回日本生化学会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膜貫通型Semaphorin Sema4Cは骨格筋分化に必須である2005

    • Author(s)
      高知 愛、権藤 俊、乾 誠
    • Organizer
      第77回日本薬理学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Modulation of NR1/NR2B subtype NMDA receptor channels by SAP-1022005

    • Author(s)
      山田 康枝、乾 誠
    • Organizer
      第77回日本薬理学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The transmembrane semaphorin Sema4C is required for myoblast differentiation2005

    • Author(s)
      Ko, J.-A.and Inui, M.
    • Organizer
      The 49th Annual Meeting of Biophysical Society
    • Place of Presentation
      Long Beach CA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Caldesmon represses an oncogenic phenotype of RSV-transformed 3Y1 cells.2005

    • Author(s)
      Morita T., et. al.
    • Organizer
      The 78th Annual Meeting of the Japanese Biochemical Society.
    • Place of Presentation
      Kobe
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism involving IGF-I signal during myogenic differentiation.2005

    • Author(s)
      Iwasaki K., et. al.
    • Organizer
      The 78th Annual Meeting of the Japanese Biochemical Society.
    • Place of Presentation
      Kobe
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Collabolation of PSD-Zip70 with SPAR in dendritic spines.2005

    • Author(s)
      Maruoka H., et. al.
    • Organizer
      The 78th Annual Meeting of the Japanese Biochemical Society.
    • Place of Presentation
      Kobe
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interaction between Grin 1 and protein 4.1 in dendritic spines.2005

    • Author(s)
      Matou K., et. al.
    • Organizer
      The 78th Annual Meeting of the Japanese Biochemical Society.
    • Place of Presentation
      Kobe
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transcriptional regulation of SMC marker genes by Msx homeoprotein family.2005

    • Author(s)
      Hayashi K., et. al.
    • Organizer
      The 78th Annual Meeting of the Japanese Biochemical Society.
    • Place of Presentation
      Kobe
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Age-and region-dependent changes in expression of nestin in aortic smooth muscle cells.2005

    • Author(s)
      Oikawa H., et. al.
    • Organizer
      The 78th Annual Meeting of the Japanese Biochemical Society.
    • Place of Presentation
      Kobe
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interaction between Glin 1 and protein 4.1 in dendrtiic.2005

    • Author(s)
      Matou K., et. al.
    • Organizer
      The 28th Annual spines Meeting of the Japan Neuroscience Society.
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel approach for advanced me dicine based on the cytoskeleton.2005

    • Author(s)
      Sobue K.
    • Organizer
      Japanese Society of Geriatric Urology.
    • Place of Presentation
      Morioka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The transmembrane semaphoring Sema4C is required for myoblast differentiation.2005

    • Author(s)
      Ko, J-A., et. al.
    • Organizer
      The 78th Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      Kobe
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The transmembrane semaphoring Sema4C is required for myoblast differentiation.2005

    • Author(s)
      Ko, J-A., et. al.
    • Organizer
      The 77th Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Modulation of NR1/NR2B subtype NMDA receptor channels by SAP-1022005

    • Author(s)
      Yamada, Y, et. al.
    • Organizer
      The 77th Annual Meeting of the Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The transmembrane semaphorin Sema4C is required for myoblast differentiation.2005

    • Author(s)
      Ko, J-A., et. al.
    • Organizer
      The 49th Annual Meeting of Biophysical Society
    • Place of Presentation
      Long BeachCA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] MAGUKsファミリー蛋白質SAP102のNR1/NR2BサブタイプNMDA型グルタミン酸受容体に対する効果2004

    • Author(s)
      山田 康枝、乾 誠
    • Organizer
      第57回日本薬理学会西南部会
    • Place of Presentation
      博多
    • Year and Date
      2004-11-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新規PDZドメイン蛋白質は骨格筋分化に必須である2004

    • Author(s)
      高知 愛、木村 佳弘、乾 誠
    • Organizer
      第57回日本薬理学会西南部会
    • Place of Presentation
      博多
    • Year and Date
      2004-11-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of a MAGUKs family protein, SAP102 on NR1/NR2B-subtype NMDA receptor channels.2004

    • Author(s)
      Yamada, Y., et. al.
    • Organizer
      The 57th Annual Meeting of the Japanese Pharmacological Society Southwestern Section
    • Place of Presentation
      Hakata
    • Year and Date
      2004-11-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel PDZ-containing protein is essential for myogenic diffarpntiatinn2004

    • Author(s)
      Ko, J-A., et. al.
    • Organizer
      The 57th Annual Meeting of the Japanesse Pharmacological Society Southwestern Section
    • Place of Presentation
      Hakata
    • Year and Date
      2004-11-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] リゾリン脂質による動脈硬化発症の分子メカニズム2004

    • Author(s)
      祖父江 憲治
    • Organizer
      第14回脳血管シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2004-09-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism of the onset of athroscleorosis.2004

    • Author(s)
      Sobue, K.
    • Organizer
      Symposium on the Brain and Blood Vessel
    • Place of Presentation
      Osaka
    • Year and Date
      2004-09-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Leucine-zipper containing PSD proteins involved in spine dynamics2004

    • Author(s)
      Sobue Kenji
    • Organizer
      Westerburg Symposium
    • Place of Presentation
      Westerburg,Germany
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Epiregulin as a major autocrine/paracrine factor released from the ERK-and p38MAPK-activated vascular smooth muscle cells2004

    • Author(s)
      林謙 一郎, 吉田 研二, 祖父江 憲治
    • Organizer
      第57回日本細胞生物学会大会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] IGF-I signalings regulated by IRS-1/SHP-2 interaction in different phenotypes of vascular smooth muscle cells2004

    • Author(s)
      林謙 一郎, 祖父江 憲治
    • Organizer
      第57回日本細胞生物学会大会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signal transduction and gene regulation involved in the phenotypic modulation of VSMCs2004

    • Author(s)
      Sobue Kenji
    • Organizer
      第57回日本細胞生物学会大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism of early onset of atherosclerosis triggered by unsaturated LPAs2004

    • Author(s)
      Sobue Kenji
    • Organizer
      FASEB Conferences
    • Place of Presentation
      Aspen,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Leucine-zipper containing PSD proteins involved in spine dynamics.2004

    • Author(s)
      Sobue, K.
    • Organizer
      Westerburg Symposium.
    • Place of Presentation
      Westerburg, Germany
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Epiregulin as a major autocrine/paracrine factor released from the ERK-and p38MAPK-activated vascular smooth muscle cells.2004

    • Author(s)
      Hayashi K., et. al.
    • Organizer
      The 57th Annual Meeting the Japan Society for Cell Biology.
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] IGF-I signaling regulated by IRS-1/SHP-2 in interaction in different phenotypes of vascular smooth muscle cells.2004

    • Author(s)
      Hayashi K., et. al.
    • Organizer
      The 57th Annual Meeting the Japan Society for Cell Biology.
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signal transduction and gene regulation irivelved in the phenotypid modulation of VSMCs.2004

    • Author(s)
      Sobue K., et. al.
    • Organizer
      The 57th Annual Meeting the Japan Society for Cell Biology.
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism of early onset of atherosclerosis triggered by unsaturated LPAs.2004

    • Author(s)
      Sobue, K.
    • Organizer
      FASEB Conferences
    • Place of Presentation
      Aspen, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Caldesmon regulates podosome/invadopodium formation and cell invasiveness in transformed and cancer cell lines.

    • Author(s)
      Morita, T., et. al.
    • Organizer
      The 40th Joint Meeting of the Japanese Society of Developmental Biologists & the Japan Society for Cell Biology.
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BMP-induced Msxl and Msx2 inhibit Myocardin-dependent transcription of smooth muscle genes.

    • Author(s)
      Nakamura, S., et. al.
    • Organizer
      The 40th Joint Meeting of the Japanese Society of Developmental Biologists & the Japan Society for Cell Biology.
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Caldesmon regulates podosome/invadopod ium formation and cell invasiveness in transformed and cancer cell lines.

    • Author(s)
      Morita, T., et. al.
    • Organizer
      The 40th Joint Meeting of the Japanese Society of Developmental Biologists & the Japan Society for Cell Biology.
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Biphasic role of Rho/ROCK signaling in myogenic differentiation : positive regulation in proliferating myoblasts and negative one in differentiating myocytes.

    • Author(s)
      Iwasaki, K., et. al.
    • Organizer
      The 40th Joint Meeting of the Japanese Society of Developmental Biologists & the Japan Society for Cell Biology.
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 医学のあゆみ2007

    • Author(s)
      林謙 一郎、祖父江 憲治
    • Publisher
      医歯薬出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 生体の科学2007

    • Author(s)
      祖父江 憲治、福本 健太郎
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 生体の科学2007

    • Author(s)
      祖父江憲治, 他
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2007 Annual Research Report
  • [Book] 医学のあゆみ2007

    • Author(s)
      林謙一郎, 他
    • Publisher
      医葉薬出版株式会社
    • Related Report
      2007 Annual Research Report
  • [Book] 血管医学2005

    • Author(s)
      森田 強、祖父江 憲治
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Molecular Mechanisms of Heart Diseases2005

    • Author(s)
      Kimura Y. et al.
    • Publisher
      Research Signpost
    • Related Report
      2005 Annual Research Report
  • [Book] IN"Atherosclerosis XIII"2004

    • Author(s)
      Sobue, K., et. al.
    • Publisher
      Elsevier
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 病理と臨床2003

    • Author(s)
      祖父江 憲治
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Publications] Usui S.et al.: "Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin."J.Biol.Chem.. 278. 10619-10628 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ebihara T.et al.: "Synchronized formation and remodeling of postsynaptic densities : long-term visualization of hippocampal neurons expressing pontsynaptic density proteins tagged with green fluorencent protein."J Neurosci.. 23. 2170-2181 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi M.et al.: "Epiregulin an a major antocrine/paracrine factor released from the ERK- and p38MAPK-activated vascular smooth muscle cells."Circulation. 108. 2524-2529 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshida K.et al.: "Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo."Circulation. 108. 1746-1752 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hori K.et al.: "MALS is a binding partner of IRSp53 at cell-cell contacts."FEBS Lett.. 554. 30-34 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohkawa Y, et al.: "Calcineurin-mediased pathway involved in the differentiated phenotype of smooth muscle cells."Biochem.Biophys.Res.Commun.. 301. 78-83 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamada N.et al.: "Role of the C domain of IGFs in the synergistic promotion with a substance P-derived peptide of rabbit corneal epithelial wound healing."Invest.Ophthalmol.Vis.Sci.. in press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iwamoto T.et al.: "Differential modulation of NRI-NR2A and NRI-NR2B subtypes of NMDA receptor by PDZ domain-containing proteins."J.Neurochem. in press. (2004)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi