• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanism underlying cell polarity and cell migration

Research Project

Project/Area Number 15GS0319
Research Category

Grant-in-Aid for Creative Scientific Research

Allocation TypeSingle-year Grants
Research InstitutionNagoya University

Principal Investigator

KAIBUCHI Kozo  Nagoya University, Graduate School of Medicine, Professor (00169377)

Co-Investigator(Kenkyū-buntansha) USUKURA Jiro  Nagoya University, Center for Cooperative Research in Advanced Science&Technology, Professor (30143415)
KURODA Shinya  University of Tokyo, Graduate School of Science, Professor (50273850)
AMANO Mutsuki  Nagoya University, Graduate School of Medicine, Associate Professor (90304170)
TAYA Shinichiro  Nagoya University, Graduate School of Medicine, Associate Professor (60362232)
ARIMURA Nariko  Tamagawa University, Brain Science Institute, COE Associate Professor (20420375)
Project Period (FY) 2003 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥317,980,000 (Direct Cost: ¥244,600,000、Indirect Cost: ¥73,380,000)
Fiscal Year 2007: ¥78,000,000 (Direct Cost: ¥60,000,000、Indirect Cost: ¥18,000,000)
Fiscal Year 2006: ¥78,000,000 (Direct Cost: ¥60,000,000、Indirect Cost: ¥18,000,000)
Fiscal Year 2005: ¥78,000,000 (Direct Cost: ¥60,000,000、Indirect Cost: ¥18,000,000)
Fiscal Year 2004: ¥83,980,000 (Direct Cost: ¥64,600,000、Indirect Cost: ¥19,380,000)
Keywordspolarily / axon / migration / CRMP-2 / Rho family / signal transduction / simulation / contraction / 細胞極性 / 遊走 / Rho / Rac / Par-3 / 軸索 / ミオシン / IQGAP / Disc1 / Kinesin / コンピューターシミュレーション / Sra-1 / WAVE1 / チューブリン / アクチン / エンドサイトーシス / 運命決定 / 神経細胞 / PAR複合体 / PI3-kinase / GSK-3β / IQGAP1 / APC / PAR-3 / KIF3A / Numb
Research Abstract

Cell polarization is an essential step for cellular functions, but the underlying mechanisms to establish and maintain cell polarity are not fully understood. We tried to clarify the signal transduction mechanisms controlling cell polarization by the use of cell migration and neuronal axon/dendrite determination as model systems.
1. Identification of extracellular signals modulating neuronal polarity and following signaling pathways.
Extracellular signals such as laminin induced the production of PIP3, inactivation of GSK-3β, and resultant activation of CRMP-2. Active CRMP-2 bound to tubulin, Sra-1, and Numb, and regulated tubulin polymerization, actin remodeling, and L1 endocytosis at growth cone, which contributed to the axon elongation and neuronal axon/dendrite determination. In addition, Par complex composed of Par-3, Pare and aPKC modulated the Rac activity through Rac GEF (Tiam1/Tiam2) to establish neuronal polarity and front-rear polarity of migrating cells.
2. Analysis of signali … More ng pathways underlying cell migration
During establishment and maintenance of front-rear polarity in cell migration, Rac/IAGAP1 regulated dynamics of both actin and microtubules through APC/CLIP-170. Rho/Rho-kinase inhibited Par complex formation and adjusted the Rac activity properly both at the front and rear.
3. Role of molecular and vesicular traffic in cell polarization and migration
CRMP-2 interacted with tubulin, Sra-1 and Slp1/TrkB, and transported them to the tip of axon as a “cargo receptor". Numb regulated integrin endocytosis at the front of migrating cell, which is supposed to be necessary for directional migration.
4. Analysis of signal networks by computer simulation
The computational model for endothelial cell contraction (activation of myosin) suggested the existence of unidentified pathway for sustained cell contraction in silico, and the novel pathway mediated by iPLA2 was identified in vivo. The computational model for establishment of front-rear polarity of migrating cells by Rho family GTPases was developed. Less

Report

(6 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (84 results)

All 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article (52 results) (of which Peer Reviewed: 18 results) Presentation (22 results) Book (2 results) Remarks (2 results) Publications (6 results)

  • [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slpl and Rab27.2009

    • Author(s)
      Arimura, N., et al.
    • Journal Title

      Dev Cell (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Anterograde Transport of TrkB in Axons is Mediated by Direct Interaction with Slp1 and Rab27.2009

    • Author(s)
      Arimura N., et al
    • Journal Title

      Dev Cell (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP.2009

    • Author(s)
      Mori, K, et al.
    • Journal Title

      J Biol Chem 284

      Pages: 5067-5076

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterograde Transport of TrkB in Axons is Mediated by Direct Interaction with Slp1 and Rab27.2009

    • Author(s)
      Arimura, N, et al.
    • Journal Title

      Dev Cell (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation.2008

    • Author(s)
      Nakayama, M., et al.
    • Journal Title

      Dev Cell 14

      Pages: 205-215

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Rho-kinase phosphorylates PAR-3 and disrupts PAR complexformation.2008

    • Author(s)
      Nakayama M., et al
    • Journal Title

      Dev Cell 14

      Pages: 205-215

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation2008

    • Author(s)
      Nakayama, M, et al.
    • Journal Title

      Dev Cell 14

      Pages: 205-215

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mass conserved reaction-diffusion system captures properties of cell polarity.2007

    • Author(s)
      Otsuji, M., et al.
    • Journal Title

      PLoS Comput Biol 3

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.2007

    • Author(s)
      Nishimura, T., et al.
    • Journal Title

      Dev Cell 13

      Pages: 15-28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Neuronal polarity : from extracellular signals to intracellular mechanisms.2007

    • Author(s)
      Arimura, N., et al.
    • Journal Title

      Nat Rev Neurosci 8

      Pages: 194-205

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A mass conserved reaction-diffusion system captures properties of cell polarity.2007

    • Author(s)
      Otsuji M., et al
    • Journal Title

      PLosS Comput Biol 3

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.2007

    • Author(s)
      Nishimura T., et al
    • Journal Title

      Dev Cell 13

      Pages: 15-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neuronal polarity: from extracellular signals to intracellular mechanisms.2007

    • Author(s)
      Arimura N., et al
    • Journal Title

      Nat Cell Biol 8

      Pages: 194-205

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells2007

    • Author(s)
      Sugimoto, M, et al.
    • Journal Title

      Biochem Biophys Res Commun 361

      Pages: 462-467

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Numb controls integrin endocytosis for directional cell migration with a PKC and PAR-32007

    • Author(s)
      Nishimura, T, et al.
    • Journal Title

      Dev Cell 13

      Pages: 15-28

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of rho kinase inhibitors (III)2007

    • Author(s)
      Iwakubo, M, et al.
    • Journal Title

      Bioorg Med Chem 15

      Pages: 1022-1033

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mass conserved reaction-diffusion system captures properties of cell polarity2007

    • Author(s)
      Otsuji, M, et al.
    • Journal Title

      PLos Comput Biol 3

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal polarity : from extracellular signals to intracellular mechanisms2007

    • Author(s)
      Arimura N., Kaibuchi K.
    • Journal Title

      Nat Rev Neucosci 8(3)

      Pages: 194-205

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IQGAP3, a novel effector of Racl and Cdc42, regulates neurite outgrowth2007

    • Author(s)
      Wang S.et al.
    • Journal Title

      J Cell Sci 120(Pt4)

      Pages: 567-577

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb22007

    • Author(s)
      Shinoda T. et al.
    • Journal Title

      J Neurosci 27(1)

      Pages: 4-14

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-12007

    • Author(s)
      Taya S.et al.
    • Journal Title

      J Neurosci 27(1)

      Pages: 15-26

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation2007

    • Author(s)
      Takefuji M. et al.
    • Journal Title

      Biochem Biophys Res Commun 355(3)

      Pages: 788-794

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Signaling networks in neuronal polarization2006

    • Author(s)
      Yoshimura T. et al.
    • Journal Title

      J Neurosci 26(42)

      Pages: 10626-10630

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ca^<2+>-independent phosphoilpase A2-dependent sustained Rho-kinase activation exhibits all-or-none response2006

    • Author(s)
      Maeda A. et al.
    • Journal Title

      Genes Cells 11(9)

      Pages: 1071-1083

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of Numb in Dendritic Spine Development with a Cdc42 GEF Intersectin and EphB2.2006

    • Author(s)
      NIshimura T. et al.
    • Journal Title

      Mol Cell Biol 17(3)

      Pages: 1273-1285

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway.2006

    • Author(s)
      Yoshimura T. et al.
    • Journal Title

      Biochem Biophys Res Commun 340(1)

      Pages: 62-68

    • Related Report
      2005 Annual Research Report
  • [Journal Article] GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.2005

    • Author(s)
      Yoshimura, T., et al.
    • Journal Title

      Cell 120

      Pages: 137-149

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiaml.2005

    • Author(s)
      Nishimura, T., et al.
    • Journal Title

      Nat Cell Biol 7

      Pages: 270-277

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Key regulators in neuronal polarity.2005

    • Author(s)
      Arimura, N., et al.
    • Journal Title

      Neuron 48

      Pages: 881-884

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.2005

    • Author(s)
      Yoshimura T., et al
    • Journal Title

      Cell 120

      Pages: 137-149

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.2005

    • Author(s)
      Nishimura T., et al
    • Journal Title

      Nat Cell Biol 7

      Pages: 270-277

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Key regulators in neuronal polarity.2005

    • Author(s)
      Arimura N., et al
    • Journal Title

      Neuron 48

      Pages: 270-277

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiaml.2005

    • Author(s)
      Nishimura T. et al.
    • Journal Title

      Nat Cell Biol 7(3)

      Pages: 270-277

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure.2005

    • Author(s)
      Hikita T. et al.
    • Journal Title

      Biochem Biophys Res Commun 335(1)

      Pages: 139-145

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.2005

    • Author(s)
      Kawano Y. et al.
    • Journal Title

      Mol Cell Biol 25(22)

      Pages: 9920-9935

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase.2005

    • Author(s)
      Kaneko T. et al.
    • Journal Title

      Genes Cells 10(10)

      Pages: 973-987

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tubulin and CRMP-2 complex is transported via Kinesin-1.2005

    • Author(s)
      Kimura T. et al.
    • Journal Title

      J Neurochem 93(6)

      Pages: 1371-1382

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Rho-kinase and myosin II activities are required for cell type and environment specific migration.2005

    • Author(s)
      Nakayama M. et al.
    • Journal Title

      Genes Cells 10(2)

      Pages: 107-117

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans.2005

    • Author(s)
      Tsuboi D. et al.
    • Journal Title

      J Neurochem 95(6)

      Pages: 1629-1641

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones.2005

    • Author(s)
      Arimura N. et al.
    • Journal Title

      Mol Cell Biol 25(22)

      Pages: 9973-9984

    • Related Report
      2005 Annual Research Report
  • [Journal Article] GSK-3β regulates phosphorylation of CRMP-2 and neuronal polarity2005

    • Author(s)
      Yoshimura T. et al.
    • Journal Title

      Cell 120

      Pages: 137-149

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration.2004

    • Author(s)
      Watanabe, T., et al.
    • Journal Title

      Dev Cell 7

      Pages: 871-883

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity.2004

    • Author(s)
      Nishimura, T., et al.
    • Journal Title

      Nat Cell Biol 6

      Pages: 328-334

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration.2004

    • Author(s)
      Watanabe T., et al
    • Journal Title

      Dev Cell 7

      Pages: 871-883

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity.2004

    • Author(s)
      Nishimura T., et al
    • Journal Title

      Nat Cell Biol 6

      Pages: 328-334

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interaction with IQGAP1 links APC to Rac1,Cdc42,and actin filaments during cell polarization and migration2004

    • Author(s)
      Watanabe T. et al.
    • Journal Title

      Dev.Cell 7・6

      Pages: 871-883

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity2004

    • Author(s)
      Nishimura T. et al.
    • Journal Title

      Nature Cell Biol. 6・4

      Pages: 328-334

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Positive role of IQGAP1,an effector of Rac1,in actin-meshwork formation at sites of cell-cell contact2004

    • Author(s)
      Noritake J. et al.
    • Journal Title

      Mol.Biol.Cell 15・3

      Pages: 1065-1076

    • Related Report
      2004 Annual Research Report
  • [Journal Article] PIP3 is involved in neuronal polarization and axon formation2004

    • Author(s)
      Menager C. et al.
    • Journal Title

      J.Neurochem. 89・1

      Pages: 109-118

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Interaction of Rho-kinase with myosin II at stress fibres.2004

    • Author(s)
      Kawabata S. et al.
    • Journal Title

      Genes Cells 9・7

      Pages: 653-660

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.2003

    • Author(s)
      Nishimura, T., et al.
    • Journal Title

      Nat Cell Biol 5

      Pages: 819-826

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth.2003

    • Author(s)
      Nishimura T., et al
    • Journal Title

      Naat Cell Biol 5

      Pages: 819-826

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Neuronal polarity and small GTPases2008

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      FASEB summer research conference on small GTPases
    • Place of Presentation
      Vermont, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Neuronal polarity and small GTPases2008

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      FASEB summer research conference on small GTPases
    • Place of Presentation
      Vermont (USA)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Discl as a cargo receptor2008

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      41th Annual Winter Conference on Brain Research
    • Place of Presentation
      Utah, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Neuronal polarity and axonal transport2008

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Gordon research conference
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2007 Annual Research Report
  • [Presentation] Neuronal polarity and small GTPases2008

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      FASEB summer research conference
    • Place of Presentation
      Vermont, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Neuronal Polarity and Axonal Vesicle Transport2008

    • Author(s)
      貝淵弘三
    • Organizer
      CDB Symposium 2008
    • Place of Presentation
      神戸
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of Numb in Dendritic Spine Development with a Cdc42 GEF Intersectin2007

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Expert Workshop on the Biology of Chromosome 21 Genes
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-09-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Signaling networks in neuronal polarization2007

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      21st Biennial Meeting of International Society of Neurochemistry
    • Place of Presentation
      Cancun, Mexico
    • Related Report
      2007 Annual Research Report
  • [Presentation] RhoファミリーとPar複合体による細胞遊走の制御2007

    • Author(s)
      貝淵弘三
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] 遊走細胞の極性制御機構2007

    • Author(s)
      貝淵弘三
    • Organizer
      第11回Molecular Cardiovascular Conference
    • Place of Presentation
      キロロ
    • Related Report
      2007 Annual Research Report
  • [Presentation] Signaling networks in neuronal polarization2006

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Neuroscience 2006, symposium
    • Place of Presentation
      Atlanta, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signaling networks in neuronal polarization2006

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Neuroscience 2006, symposium
    • Place of Presentation
      Atlanta (USA)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Neuronal polarity and cytoskeleton2005

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      20th Biennial Meeting of International Society of Neurochemistry, symposium
    • Place of Presentation
      Innsbruck, Austria
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signaling for Neuronal Polarity2005

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Keystone Symposia on cell migration and adhesion
    • Place of Presentation
      Utah, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Neuronal Polarity and Cytoskeleton2005

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Keystone Symposia on molecular and cellular biology
    • Place of Presentation
      Idaho, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roles of Rho family in cell migration and polarity2005

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Nature Biotechnology Winter Symposium
    • Place of Presentation
      Miami, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Neuronal polarity and cytoskeleton2005

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      20th Biennial Meeting of International Society of Neurochemistry, symposium
    • Place of Presentation
      Innsbruck (Austria)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signaling for Neuronal Polarity2005

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Keystone Symposia on cell migration and adhesion
    • Place of Presentation
      Utah (USA)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Neuronal Polarity and Cytoskeleton2005

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Keystone Symposia on cell migration and adhesion
    • Place of Presentation
      Idaho (USA)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roles of Rho family in cell migration and polarity2005

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Nature Biotechnology Winter Symposium
    • Place of Presentation
      Miam (USA)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roles of Rho family GTPases in cell polarization and directional migration2003

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      43^<th> Annual meeting of ASCB, symposium
    • Place of Presentation
      San Francisco, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roles of Rho family GTPases in cell polarization and directional migration2003

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      43^<th> Annual meeting of ASCB, symposium
    • Place of Presentation
      San Francisco (USA)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 細胞骨格と接着2006

    • Author(s)
      貝淵弘三, 稲垣昌樹, 佐邊壽孝, 松崎文雄編
    • Total Pages
      323
    • Publisher
      共立出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Cytoskeleton and Cell Adhesion2006

    • Author(s)
      Kaibuchi K., et al (ed)
    • Publisher
      Kyoritsu Shuppan Co., Ltd
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/

    • Related Report
      2007 Annual Research Report
  • [Publications] Nishimura T. et al.: "Role of the PAR-3/KIF3 complex in the establishment of neuronal polarity"Nature Cell Biol.. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noritake J. et al.: "Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact"Mol.Biol.Cell. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Menager C. et al.: "PIP_3 is involved in neuronal polarization and axon formation"J.Neurochem.. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishimura T. et al.: "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth"Nature Cell Biol.. 5・9. 819-826 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fukata M. et al.: "Roles of Rho-family GTPases in cell polarisation and directional migration"Curr.Opin.Cell Biol.. 15・5. 590-597 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Amano M. et al.: "Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase"J.Neurochem.. 87・3. 780-790 (2003)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi