Construction of Control System for Behavior Programming of Molecular Robots
| Project/Area Number |
15H01715
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中茎 隆 九州工業大学, 大学院情報工学研究院, 教授 (30435664)
川又 生吹 東北大学, 工学研究科, 助教 (30733977)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2015: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
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| Keywords | 分子ロボット / DNAコンピューティング / シーケンス制御 / レギュレータ / DNAコンピュータ / 分子ロボティクス |
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| Outline of Final Research Achievements |
In this research, we introduce the methodology of control engineering such as sequence control into the DNA-based Chemical Reaction System to develop methodology for the sequential programming of the molecular robot. Two basic methods have been developed in this project:A. A chain generation circuit (PSG) that sequentially outputs DNA strands in a preprogrammed time seriesB. Concentration regulator (CR) based on discontinuous control theory．
For the former, sequencing control using a reaction system (PSG) that generates control DNA strands with time difference for the open / close experiments of molecular devices called DNA tweezers and an aggregation control system of molecular motors called microtubule motility assay. For the latter, the behavior of the system is analyzed by the singular perturbation theory utilizing the characteristics of DNA reaction system, which enables us to evaluate the influence of the crosstalk to the observed output of the system measured by L2 gain.
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| Academic Significance and Societal Importance of the Research Achievements |
一般に化学反応は非線形性の強いシステムであり，その特性の解析が議論の中心となっている．分子ロボットで求められているのは，化学反応をなるべく錯綜させずに整理して制御する「設計」の方法論であるが，その方面の研究はほとんど行われていない．そこで，本研究においては，分子ロボットにシーケンス制御などのマクロシステムで確立された制御工学の方法論を導入した．具体的には，分子ロボットの行動プログラムのために必要な２つの基本回路，すなわち，(1)あらかじめプログラムした時系列でDNA 鎖を順次出力する鎖生成回路（PSG），(2)不連続制御理論に基づく濃度レギュレータ回路（CR）の設計法および実装技術を開発した．
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Report
(5 results)
Research Products
(75 results)
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[Journal Article] DNA cytoskeleton for stabilizing artificial cells2017
Author(s)
Kurokawa Chikako、Fujiwara Kei、Morita Masamune、Kawamata Ibuki、Kawagishi Yui、Sakai Atsushi、Murayama Yoshihiro、Nomura Shin-ichiro M.、Murata Satoshi、Takinoue Masahiro、Yanagisawa Miho
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 114
Issue: 28
Pages: 7228-7233
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Revolving Vernier Mechanism Controls Size of Linear Homomultimer2017
Author(s)
Takeo Uchida, Keita Abe, Yuma Endo, Shosei Ichiseki, Satoru Akita, Shiyun Liu, Sho Aradachi, Masataka Saito, Akihiko Fukuchi, Taiyo Kikkawa, Theo Dammaretz, Ibuki Kawamata, Yuki Suzuki, Shin-ichiro M. Nomura, Satoshi Murata
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Journal Title
Small
Volume: 13
Issue: 41
Pages: 1702158-1702158
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Self-replication of DNA rings2015
Author(s)
Junghoon Kim,Junwye Lee,Shogo Hamada,Satoshi Murata& Sung Ha Park
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Journal Title
Nature Nanotechnology
Volume: 10
Issue: 6
Pages: 528-533
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] In situ 2D-extraction of DNA wheels by 3D through-solution transport2015
Author(s)
Yusuke Yonamine *ab, Keitel Cervantes-Salguero *c, Waka Nakanishi *a, Ibuki Kawamata c, Kosuke Minami a, Hirokazu Komatsu a, Satoshi Murata *c, Jonathan P. Hill ab and Katsuhiko Ariga *ab
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Journal Title
Phys. Chem. Chem. Phys.
Volume: 17
Issue: 48
Pages: 32122-32125
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 伸縮可能なミウラ折りDNA折り紙2019
Author(s)
Daiki Matsumoto ,Toma Ito, Yuki Kato, Kensei Kikuchi, Hiroki Sawada, Syuu Syou, Airi Nakayama,Hao Wu, Kosuke Hori, Motokazu Huruya,Minato Miyake, Koutaro Watabe, Ibuki Kawamata, Yuki Suzuki, Shin-ichiro M. Nomura, Satoshi Murata
Organizer
第二回分子ロボティクス年次大会, 東工大学大岡山キャンパス
Related Report
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[Presentation] Linear Nanostructure with Limited Lengths by Revolving Vernier Mechanism2017
Author(s)
Takeo Uchida, Keita Abe, Yuma Endo, Shosei Ichiseki, Satoru Akita, Shiyun Liu, Sho Aradachi, Masataka Saito, Akihiko Fukuchi, Taiyo Kikkawa,Theo Dammaretz, Ibuki Kawamata, Yuki Suzuki, Shin-ichiro M. Nomura, and Satoshi Murata
Organizer
FNANO17
Related Report
Int'l Joint Research
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[Presentation] 周期状態遷移を行う非同期セルオートマトン2016
Author(s)
礒川 悌次郎 (兵庫県立大学), ペパー フェルディナンド (情報通信研究機構), 川又 生吹 (東北大学), 松井 信之 (兵庫県立大学 ), 村田 智 (東北大学), 萩谷 昌己 (東京大学)
Organizer
計測自動制御学会 システム・情報部門 学術講演会 (SSI2016）
Place of Presentation
ウカルちゃんアリーナ（大津市)
Year and Date
2016-12-06
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