| Budget Amount *help |
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2015: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
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| Outline of Final Research Achievements |
In this research, we introduce the methodology of control engineering such as sequence control into the DNA-based Chemical Reaction System to develop methodology for the sequential programming of the molecular robot. Two basic methods have been developed in this project:A. A chain generation circuit (PSG) that sequentially outputs DNA strands in a preprogrammed time seriesB. Concentration regulator (CR) based on discontinuous control theory．
For the former, sequencing control using a reaction system (PSG) that generates control DNA strands with time difference for the open / close experiments of molecular devices called DNA tweezers and an aggregation control system of molecular motors called microtubule motility assay. For the latter, the behavior of the system is analyzed by the singular perturbation theory utilizing the characteristics of DNA reaction system, which enables us to evaluate the influence of the crosstalk to the observed output of the system measured by L2 gain.
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