| Budget Amount *help |
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2018: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2017: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2016: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2015: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Outline of Final Research Achievements |
We developed softwares to understand the reason why missing heritability appears in GWAS analysis by extending Limitless-Arity Muliple-testing Procedure (LAMP). We performed four researches. 1. We developed LAMPLINK, in which LAMP is integrated into PLINK, widely used GWAS analysis software. 2. We developed HWY, in which we utilized General Purpose GPU to accelerate GWAS statistical calculations with permutation test procedure for comprehensive calculation of the statistics of pairs of SNPs efficiently. 3. We collaborated with the two largest cohorts in Japan, Biobank Japan and Tohoku Medical Megabank, and we applied LAMP to the datasets. 4. We extend LAMP to handle survival curves used in long-term cohort. It also applicable to somatic mutation analysis in cancer cells. Integrating these tools allows us to understand the keys of missing heritability.
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