| Budget Amount *help |
¥40,300,000 (Direct Cost: ¥31,000,000、Indirect Cost: ¥9,300,000)
Fiscal Year 2017: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2016: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2015: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
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| Outline of Final Research Achievements |
We found that BAF complex belonging to the SWI/SNF family for ATP-dependent chromatin remodeling (nucleosome remodeling) not only contributes to transcriptional regulation but also to DNA repair of various types of DNA damage and identified BAF factors involved in DNA repair. ARID1A and ARID1B, mutually exclusive variant factors for transcription in BAF complex, turned out to interact with KU protein and to contribute to DNA double-strand break repair. Thus, when cell ages, nucleosome remodeling, DNA repair and transcriptional regulation can build a negative feedback loop to promote tumorigenesis and accelerate cellular aging, as DNA repair defect creates mutation influencing NR and TR.
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