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Nuclear receptor-mediated bisphenol endocrine disrupting signal toxicity

Research Project

Project/Area Number 15H01741
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation and chemicals
Research InstitutionKyushu University

Principal Investigator

SHIMOHIGASHI Yasuyuki  九州大学, 理学研究院, 名誉教授 (00211293)

Co-Investigator(Kenkyū-buntansha) 中川 裕之  福岡大学, 理学部, 教授 (80274562)
松島 綾美  九州大学, 理学(系)研究科(研究院), 准教授 (60404050)
劉 暁輝  九州大学, 理学(系)研究科(研究院), 助教 (60596849)
Co-Investigator(Renkei-kenkyūsha) LIU Xiaohui  九州大学, 大学院理学研究院, 助教 (60596849)
MATSUSHIMA Ayami  九州大学, 大学院理学研究院, 准教授 (60404050)
Research Collaborator SHIMOHIGASHI Miki  
MATSUO Ayaka  
MATSUYAMA Yutaka  
SUGIYAMA Makiko  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2017: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2016: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2015: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Keywords有害化学物質 / 内分泌かく乱物質 / ビスフェノール / 核内受容体 / シグナル毒性 / ビスフェノールA
Outline of Final Research Achievements

The aim of this project is to clarify the nuclear receptor-mediated molecular mechanisms of signal toxicity and low-dose effects of endocrine disruptor bisphenol A. As a result, the followings to prove those objectives have been elucidated. Those include (i) BPA-exposure causes hyperactivity both in the fruit fly Drosophila, and mice, (ii) such hyperactivity was found to associate with the disorder of genes of circadian rhythm-transmitting neuropeptides, (iii) the disorder appeared to originate from the suppression or facilitation of DNA methylation, and (iv) BPA’s high transcriptional activation activity is due to the cooperative work with highly constitutively active self-activated nuclear receptors.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (78 results)

All 2018 2017 2016 2015

All Journal Article (26 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 23 results,  Acknowledgement Compliant: 19 results) Presentation (52 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Phe271 at position 5.39 of thrombin receptor PAR-1 is a specific target of Phe-2-phenyl group of its tethered ligand2018

    • Author(s)
      M. Sugiyama, T. Fujita, X. Liu, Y. Matsuyama, A. Matsushima, M. Shimohigashi, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2017

      Volume: - Pages: 94-95

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homodimer function of human nuclear receptor ERRα evidenced using α-helix peptides in the dimer interface2018

    • Author(s)
      X. Liu, H. Nakagawa, M. Sugiyama, A. Matsushima, M. Shimohigashi, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2017

      Volume: - Pages: 190-191

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutual co-work between nuclear receptor ERα and ERRγ requires their homodimerization2018

    • Author(s)
      X. Liu, M. Shimohigashi, M. Sugiyama, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2017

      Volume: - Pages: 198-199

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Docking simulation to elucidated the labeled cysteine residue of the nociception receptor ORL1 using a Cys(Npys)-containing peptide ligand2017

    • Author(s)
      A. Matsushima, H. Nishimura, Y. Matsuyama, X. Liu, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2016

      Volume: - Pages: 87-88

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents2017

    • Author(s)
      Torikai Kohei、Koga Rintaro、Liu Xiaohui、Umehara Kaoru、Kitano Tatsuya、Watanabe Kenji、Oishi Tohru、Noguchi Hiroshi、Shimohigashi Yasuyuki
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 25 Issue: 20 Pages: 5216-5237

    • DOI

      10.1016/j.bmc.2017.07.067

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-Helix-peptides composing the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization - Bisphenol A receptor ERRγ physiologically functions as homodimer2017

    • Author(s)
      X. Liu, H. Nishimura, A. Fujiyama, A. Matsushima, M. Shimohigashi, and Y. Shimohigashi
    • Journal Title

      Biomedical Advances

      Volume: -

    • Related Report
      2017 Annual Research Report
  • [Journal Article] SCN circadian rhythm signal transduction neuropeptides evoke hypoactive phenotype differently in male and female mice2016

    • Author(s)
      M. Sugiyama, Y. Motomatsu, Y. Matsuyama, S. Kajiyama, T. Kameda, T. Saito, E. Uchimura, X. Liu, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2015

      Volume: - Pages: 53-54

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Functional role of the Phe-Phe stacking microswitch in the ORL1 nociceptin receptor activation2016

    • Author(s)
      Y. Takesue, H. Nishimura, X. Liu, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2015

      Volume: - Pages: 147-148

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comprehensive structural analysis of the nociceptin ORL1 receptor by means of virtual and experimental Ala-scanning combined methods2016

    • Author(s)
      A. Matsushima, H. Nishimura, X. Liu, Y. Takesue, Y. Matsuyama, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2015

      Volume: - Pages: 149-150

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ORL1 Nociceptin Receptor Response of Opioid Peptides Derived from Proenkephalin Precursor Protein2016

    • Author(s)
      Y. Motomatsu, H. Nishimura, Y. Matsuyama, X. Liu, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2015

      Volume: - Pages: 181-182

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expression analysis of neuropeptide pdf mRNA in the hypoactive and hyperactive fruit flies Drosophila melanogaster2016

    • Author(s)
      A. Tokumaru, A. Matsuo, S. Umeno, Y. Matsuyama, M. Nakamura, M. Sumiyoshi, X. Liu, A. Matsushima, M. Shimohigashi, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2015

      Volume: - Pages: 317-318

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Protein constitutive peptide fragments to inhibit protein-protein interaction: inhibitory peptides as molecular probe for clarification of human nuclear receptor activation mechanism2016

    • Author(s)
      X. Liu, M. Shimohigashi, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2015

      Volume: - Pages: 319-320

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Do the estrogen receptors function as a homodimer? Experimental validation of homodimerization by inhibitory peptides2016

    • Author(s)
      S. Sakito, X. Liu, A. Fujiyama, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2015

      Volume: - Pages: 335-336

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparative analyses of the ligand binding domain secondary structures of human nuclear receptors2016

    • Author(s)
      Y. Matsuyama, H. Nishimura, X. Liu, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2015

      Volume: - Pages: 337-338

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 内分泌撹乱物質「ビスフェノール」のホルモン受容体応答2016

    • Author(s)
      下東康幸
    • Journal Title

      學士會会報

      Volume: 919 Pages: 93-97

    • NAID

      40020897327

    • Related Report
      2016 Annual Research Report
  • [Journal Article] α-Helix-Peptides Composing the Human Nuclear Receptor ERRγ Competitively Provoke Inhibition of Functional Homomeric Dimerization.2016

    • Author(s)
      X. Liu, H. Nishimura, A. Fujiyama, A. Matsushima, M. Shimohigashi, and Y. Shimohigashi
    • Journal Title

      Biopolymers: Peptide Science

      Volume: なし Issue: 4 Pages: 547-554

    • DOI

      10.1002/bip.22795

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand.2016

    • Author(s)
      A. Matsushima, H. Nishimura, Y. Matsuyama, X. Liu, T. Costa, and Y. Shimohigashi
    • Journal Title

      Biopolymers: Peptide Science

      Volume: なし Issue: 4 Pages: 460-469

    • DOI

      10.1002/bip.22792

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The molecular switching of ORL1 nociceptin receptor in activation/inactivation.2015

    • Author(s)
      H. Nishimura, J. Li, K. Isozaki, Y. Takesue, X. Liu, S. Inamine, A. Matsushima, T. Costa, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2014

      Volume: なし Pages: 201-202

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Receptor selectivity and specificity of a series of opioid peptides latent in the proenkephalin precursor protein.2015

    • Author(s)
      Y. Motomatsu, H. Nishimura, Y. Matsumoto, Y. Kuramitsu, S. Inamine, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2014

      Volume: なし Pages: 205-206

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Alternative polyadenylation analyses of neuropeptide genes in bisphenol A-exposed hypoactive mouse brain.2015

    • Author(s)
      M. Sugiyama, S. Kajiyama, T. Saito, E. Uchimura, Y. Motomatsu, A. Matsuo, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2014

      Volume: なし Pages: 345-346

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A novel method to identify and quantify the coactivator proteins that couple with human nuclear receptor: The use of interacting interface α-helix peptide for quantitative inhibition.2015

    • Author(s)
      X. Liu, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2014

      Volume: なし Pages: 349-350

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Bisphenol A-Induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression.2015

    • Author(s)
      S. Umeno, A. Matsuo, Y. Matsuyama, M. Nakamura, K. Koga, X. Liu, A. Matsushima, M. Shimohigashi, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2014

      Volume: なし Pages: 41-42

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] GPCR functional role of Phe-269 and Phe-221 in the molecular switching of ORL1 nociceptin receptor activation.2015

    • Author(s)
      Y. Takesue, H. Nishimura, X. Liu, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2014

      Volume: なし Pages: 203-204

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] An in silico genomic search of endomorphin-like opioid peptides.2015

    • Author(s)
      A. Matsushima, K. Koyanagi, H. Nishimura, S. Inamine, Y. Motomatsu, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2014

      Volume: なし Pages: 281-282

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structural and molecular evolutionary analysis of the ligand-binding domain of forty-eight human nuclear receptors.2015

    • Author(s)
      Y. Matsuyama, H. Nishimura, X. Liu, A. Matsushima, and Y. Shimohigashi
    • Journal Title

      Peptide Science 2014

      Volume: なし Pages: 347-348

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 乳がん細胞におけるビスフェノールのエストロゲン様活性2015

    • Author(s)
      劉 暁輝, 松島綾美, 下東康幸
    • Journal Title

      BIO Clinica

      Volume: 30 Pages: 1010-1015

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] 自発活性化型核内受容体ERRα、ERRβ、ERRγは異なった作用様式で甲状腺ホルモン受容体を活性増強する2017

    • Author(s)
      松山祐昂・劉 暁輝・杉山真季子・松島綾美・下東美樹・下東康幸
    • Organizer
      平成29年度日本生化学会九州支部例会・宮日会館・宮崎大学清武キャンパス(宮崎市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 不活性なAF1ドメイン欠損 ERαは自発活性化型核内受容体 ERRの協働作用により活性化する2017

    • Author(s)
      劉 暁輝・松山祐昂・杉山真季子・松島綾美・下東美樹・下東康幸
    • Organizer
      平成29年度日本生化学会九州支部例会・宮日会館・宮崎大学清武キャンパス(宮崎市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ビスフェノールA暴露・低活動性症状マウス脳内の自閉症関連遺伝子の発現解析2017

    • Author(s)
      杉山真季子・松山祐昂・劉 暁輝・松島綾美・下東美樹・下東康幸
    • Organizer
      平成29年度日本生化学会九州支部例会・宮日会館・宮崎大学清武キャンパス(宮崎市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Phe271-5.39 of thrombin receptor PAR-1 is a specific target of Phe-2-phenyl group of its tethered ligand2017

    • Author(s)
      杉山真季子・藤田亜美・劉 暁輝・松山祐昂・松島綾美・松山祐昂・下東康幸
    • Organizer
      第54回ペプチド討論会・大阪府立大学(堺市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Homodimer function of human nuclear receptor ERRα evidenced using α-helix peptides in the dimer interface2017

    • Author(s)
      劉 暁輝・中川裕之・杉山真季子・松島綾美・下東美樹・下東康幸
    • Organizer
      第54回ペプチド討論会・大阪府立大学(堺市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Mutual co-work between nuclear receptor ERα and ERRγ requires their homodimerization2017

    • Author(s)
      劉 暁輝・下東美樹・杉山真季子・松島綾美・下東康幸
    • Organizer
      第54回ペプチド討論会・大阪府立大学(堺市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chemical library screening of newly utilized bisphenol derivatives known as environmental chemicals to identify the novel binders to human estrogen receptor alpha(エストロゲン受容体αに結合する環境化学物質・新世代ビスフェノール類のライブラリースクリーニング)2017

    • Author(s)
      松島綾美・枡屋宇洋・劉 暁輝・下東康幸
    • Organizer
      第90回日本生化学会大会・神戸ポートアイランド(神戸市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Inactive AF1 domain-lacking ERα isomer is activated by constitutively active human nuclear receptor ERRα and ERRγ (不活性なERα-AF1ドメイン欠損体は自発活性化型核内受容体ERRにより活性化される)2017

    • Author(s)
      劉 暁輝・松山祐昂・杉山真季子・松島綾美・下東美樹・下東康幸
    • Organizer
      第90回日本生化学会大会・神戸ポートアイランド(神戸市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Transcriptional activity of thyroid hormone receptors are reinforced strongly by constitutively self-activating nuclear receptors (甲状腺ホルモン受容体の転写活性は構成的自発活性な核内受容体により強く増強される)2017

    • Author(s)
      松山祐昂・劉 暁輝・杉山真季子・松島綾美・下東美樹・下東康幸
    • Organizer
      第90回日本生化学会大会・神戸ポートアイランド(神戸市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Bisphenol A-exposed mouse hypoactivity associates with increased or decreased expression of circadian rhythm-mediating neuropeptide mRNAs(ビスフェノールA暴露によるマウス低活動性症状は概日リズム伝達は神経ペプチド遺伝子の発現異常を伴う)2017

    • Author(s)
      杉山真季子・松山祐昂・劉 暁輝・松島綾美・下東美樹・下東康幸
    • Organizer
      第90回日本生化学会大会・神戸ポートアイランド(神戸市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 核内受容体 ERRs は不活性 ERα- AF1 ドメイン欠損体とも協働してビスフェノールA低用量効果を示す2016

    • Author(s)
      劉 暁輝・松山祐昂・下東美樹・下東康幸
    • Organizer
      環境ホルモン学会 第19回研究発表会
    • Place of Presentation
      文部科学省 研究交流センター(つくば市)
    • Year and Date
      2016-12-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト甲状腺ホルモン受容体の活性増強因子として働く構成的に自発活性な核内受容体2016

    • Author(s)
      松山祐昂・劉 暁輝・杉山真季子・松島綾美・下東康幸
    • Organizer
      環境ホルモン学会 第19回研究発表会
    • Place of Presentation
      文部科学省 研究交流センター(つくば市)
    • Year and Date
      2016-12-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 仔マウスにビスフェノールA暴露が誘起する低活動性症状の原因遺伝子探索2016

    • Author(s)
      杉山真季子・斎藤辰弥・亀田朋典・松山祐昂・劉 暁輝・松島綾美・下東美樹・下東康幸
    • Organizer
      環境ホルモン学会 第19回研究発表会
    • Place of Presentation
      文部科学省 研究交流センター(つくば市)
    • Year and Date
      2016-12-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] A gene depressing an initial elongation of neurite from Drosophila neural cell2016

    • Author(s)
      Mio Ogawa, Miharu Nagaishi, Hiroki Ise, Hiroyuki Nakagawa
    • Organizer
      The 22nd International Congress of Zoology
    • Place of Presentation
      Okinawa Institute of Science and Technology Graduate University (Onnason, Okinawa)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ビスフェノールA食餌はマウスを低活動性症状にする:ビスフェノールAの概日リズム神経ペプチドへの雌雄で異なる影響2016

    • Author(s)
      杉山真季子・斎藤辰弥・亀田朋典・松山祐昂・劉 暁輝・松島綾美・下東美樹・下東康幸
    • Organizer
      第40回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Place of Presentation
      指宿ベイテラス(鹿児島県指宿市東方)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 自発活性化型核内受容体による甲状腺ホルモン受容体の活性増強2016

    • Author(s)
      松山祐昂・劉 暁輝・松島綾美・下東康幸
    • Organizer
      第40回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Place of Presentation
      指宿ベイテラス(鹿児島県指宿市東方)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 構成活性な自発活性化型核内受容体はリガンド活性化型核内受容体を識別・認識して特異的に活性増強する2016

    • Author(s)
      松山祐昂・劉 暁輝・池田 伸・松島綾美・下東康幸
    • Organizer
      平成28年度日本生化学会九州支部例会
    • Place of Presentation
      鹿児島大学 稲盛会館(鹿児島市)
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] エストロゲン受容体ERおよびエストロゲン関連受容体ERRのホモダイマー機能のダイマー化阻害ペプチドによる証明2016

    • Author(s)
      劉 暁輝・﨑戸沙耶・藤山明菜・西村裕一・松島綾美・下東美樹・下東康幸
    • Organizer
      平成28年度日本生化学会九州支部例会
    • Place of Presentation
      鹿児島大学 稲盛会館(鹿児島市)
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 低活動性症状動物の概日リズム伝達神経ペプチド遺伝子へのビスフェノールA食餌の影響2016

    • Author(s)
      杉山真季子・斎藤辰弥・松尾文香・亀田朋典・徳丸飛鳥・府本 優・劉 暁輝・松島綾美・下東美樹・下東康幸
    • Organizer
      平成28年度日本生化学会九州支部例会
    • Place of Presentation
      鹿児島大学 稲盛会館(鹿児島市)
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ペプチド科学研究に寄与する非ペプチド研究2016

    • Author(s)
      下東康幸
    • Organizer
      フォーラム「生命科学談話シリーズ」アミノ酸・ペプチド・タンパク質のバイオケミストリ
    • Place of Presentation
      九州大学 博多駅オフィス講義室(福岡市 JR 博多シティ)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 遺伝子への影響から行動異常まで見えてきたビスフェノールA暴露マウスの悪作用分子メカニズム(Bisphenol-A molecular mechanism in behavior disorder based on varied gene expression)2015

    • Author(s)
      杉山真季子・松島綾美・元松雄大・松山祐昂・梶山祥太・亀田朋典・斎藤辰弥・内村恵理子・松尾文香・劉 暁輝・下東美樹・下東康幸
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学 地域医療情報研修センター (下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ビスフェノールAのシグナル毒性に関与するヒト核内受容体は二量体で機能する(Human nuclear receptors work as a homodimer to exert the signaling toxicity of bisphenol A)2015

    • Author(s)
      劉 暁輝・西村裕一・藤山明菜・崎戸沙耶・松島綾美・下東美樹・下東康幸
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学 地域医療情報研修センター (下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ERα-ERRα協働作用におけるDNAホルモン応答配列を繋ぐスペーサー間隔の影響(Exploration of optimized nucleotide spacer length between the hormone response elements for the ERα–ERRα synergistic transcriptional function)2015

    • Author(s)
      松島綾美・劉 暁輝・池田 伸・下東康幸
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学 地域医療情報研修センター (下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] エストロゲン関係受容体の協働作用によりビスフェノールAの低用量効果が生まれる分子メカニズム(The molecular mechanism of a low-dose effect of bisphenols by the synergetic interaction of estrogen-related receptors)2015

    • Author(s)
      劉 暁輝・池田 伸・松島綾美・下東康幸
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学 地域医療情報研修センター (下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ビスフェノールA食餌ショウジョウバエの多動性症状は概日リズム伝達神経ペプチドPDF遺伝子の発現低下に起因する(Hyperactivity of bisphenol A-fed fruit fly Drosophila melanogaster is caused by decreased expression of circadian neurotransmitter peptide pigment dispersing factor gene)2015

    • Author(s)
      松尾文香・梅野翔太郎・徳丸飛鳥・中村将行・住吉美保・劉 暁輝・松島綾美・下東美樹・下東康幸
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学 地域医療情報研修センター (下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 内分泌撹乱化学物質が標的とするヒト核内受容体48種におけるリガンド結合ドメイン二次構造解析(Detailed analysis of the secondary structures of ligand binding domain in human nuclear receptors as a target for endocrine disruptor)2015

    • Author(s)
      松山祐昂・西村裕一・劉 暁輝・松島綾美・下東康幸
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学 地域医療情報研修センター (下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] BPA暴露マウスの低活動性症状は雌雄で異なる遺伝子が原因である(Hypoactivity of bisphenol A-exposed mouse proceeds by the genes different between sexes)2015

    • Author(s)
      杉山真季子・松島綾美・元松雄大・松山祐昂・梶山祥太・亀田朋典・斎藤辰弥・内村恵理子・松尾文香・劉 暁輝・下東美樹・下東康幸
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学 地域医療情報研修センター (下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ビスフェノール活性に必須なエストロゲン受容体のダイマー化構造要因(Human nuclear receptors work as a homodimer to exert the signaling toxicity of bisphenol A)2015

    • Author(s)
      崎戸沙耶・藤山明菜・劉 暁輝・松島綾美・下東康幸
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学 地域医療情報研修センター (下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ビスフェノールA暴露によるショウジョウバエ核内受容体mRNAへの影響解析(Human nuclear receptors work as a homodimer to exert the signaling toxicity of bisphenol A)2015

    • Author(s)
      松尾文香・佐藤俊介・梅野翔太郎・木村僚子・徳丸飛鳥・劉 暁輝・松島綾美・下東美樹・下東康幸
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学 地域医療情報研修センター (下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ビスフェノールA暴露によるショウジョウバエの活動障害:神経ペプチドPDFにおける一塩基多型(Bisphenol A-induced Drosophila hypoactivity: Identification of multiple single nucleotide polymorphism in the pacemaker hormone neuropeptide PDF mRNA)2015

    • Author(s)
      徳丸飛鳥・松尾文香・梅野翔太郎・松山祐昴・中村将行・住吉美保・劉 暁輝・松島綾美・下東美樹・下東康幸
    • Organizer
      環境ホルモン学会第18回研究発表会
    • Place of Presentation
      自治医科大学 地域医療情報研修センター (下野市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] エストロゲン受容体-エストロゲン関連受容体の協働的転写活性増強にDNAホルモン応答配列間スペーサー領域が及ぼす影響 (Synergetic effect on transcription activity enhancement between ER and ERR nuclear receptors depends upon the spacer structure of DNA hormone response elements)2015

    • Author(s)
      松島綾美・劉 暁輝・池田 伸・下東康幸
    • Organizer
      BMB2015 第88回日本生化学会大会-第38回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 核内受容体ERおよびERRの協働作用による転写活性増強の分子メカニズム (Molecular mechanism of transcription activity enhancement in the synergetic interaction between the nuclear receptors ER and ERR)2015

    • Author(s)
      劉 暁輝・池田 伸・松島綾美・下東康幸
    • Organizer
      BMB2015 第88回日本生化学会大会-第38回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト核内受容体リガンド結合ポケット底部のβストランド数を違えた構造構築とリガンド結合の多様性 (Human nuclear receptors drive the signaling ligand binding by diverse structural construction with multifarious subsets of β-strand)2015

    • Author(s)
      松山祐昂・劉 暁輝・西村裕一・松島綾美・下東康幸
    • Organizer
      BMB2015 第88回日本生化学会大会-第38回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 視交叉上核神経ペプチドが誘導する雌雄で異なるマウス概日行動の制御 (With bisphenol A-exposure SCN neuropeptides regulate the circadian behavior differently between male and female mice)2015

    • Author(s)
      杉山真季子・元松雄大・梶山翔太・亀田朋典・斎藤辰弥・内村恵梨子・松尾文香・劉 暁輝・松島綾美・下東美樹・下東康幸
    • Organizer
      BMB2015 第88回日本生化学会大会-第38回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] エストロゲン受容体の受容体活性化におけるホモダイマー化の構造要因 (Estrogen receptor structural essentials in the homodimerization necessary for receptor activation)2015

    • Author(s)
      﨑戸沙耶・藤山明菜・劉 暁輝・松島綾美・下東康幸
    • Organizer
      BMB2015 第88回日本生化学会大会-第38回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自発活性化型核内受容体SF1が介添えするエストロゲン受容体転写活性の増強 (Reinforcement of estrogen receptor transcriptional activity with synergetic effect of the self-activated nuclear receptor SF1)2015

    • Author(s)
      佐藤俊介・劉 暁輝・松島綾美・下東康幸
    • Organizer
      BMB2015 第88回日本生化学会大会-第38回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] ORL1疼痛受容体活性化における新規な分子スイッチ (A novel molecular switch mechanism in algetic ORL1 receptor activation)2015

    • Author(s)
      武末祐貴・西村裕一・劉 暁輝・松島綾美・下東康幸
    • Organizer
      BMB2015 第88回日本生化学会大会-第38回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] プロエンケファリン前駆体からプロセッシングされる全オピオイドペプチドの受容体サブタイプ特異性 (Receptor Subtype Specificity of Proenkephalin Precursor Protein-Based Opioid Peptides)2015

    • Author(s)
      元松雄大・西村裕一・松本結香・蔵満由美・稲嶺翔吾・劉 暁輝・松島綾美・下東康幸
    • Organizer
      BMB2015 第88回日本生化学会大会-第38回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] SCN Circadian Rhythm Signal Transduction Neuropeptides Evoke Hypoactive Phenotype Differently in Male and Female Mice2015

    • Author(s)
      Makiko Sugiyama, Yudai Motomatsu, Yutaka Matsuyama, Shouta Kajiyama, Tomonori Kameda, Tatsuya Saito, Eriko Uchimura, Xiaohui Liu, Ayami Matsushima, and Yasuyuki Shimohigashi
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚中央公民館(神奈川県平塚市)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Functional Role of the Phe-Phe Stacking Microswitch in the ORL1 Nociceptin Receptor Activation.2015

    • Author(s)
      Yuuki Takesue, Hirokazu Nishimura, Xiaohui Liu, Ayami Matsushima, and Yasuyuki Shimohigashi
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚中央公民館(神奈川県平塚市)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Comprehensive Structural Analysis of the Nociceptin ORL1 Receptor by Means of Virtual and Experimental Ala-Scanning Combined Methods.2015

    • Author(s)
      Ayami Matsushima, Hirokazu Nishimura, Xiaohui Liu, Yuuki Takesue, Yutaka Matsuyama, and Yasuyuki Shimohigashi
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚中央公民館(神奈川県平塚市)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] ORL1 Nociceptin Receptor Response of Opioid Peptides Derived from Proenkephalin Precursor Protein.2015

    • Author(s)
      Yudai Motomatsu, Hirokazu Nishimura, Yutaka Matsuyama, Xiaohui Liu, Ayami Matsushima, and Yasuyuki Shimohigashi
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚中央公民館(神奈川県平塚市)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Expression Analysis of Neuropeptide pdf mRNA in the Hypoactive and Hyperactive Fruit Flies Drosophila melanogaster.2015

    • Author(s)
      Asuka Tokumaru, Ayaka Matsuo, Shotaro Umeno, Yutaka Matsuyama, Masayuki Nakamura, Miho Sumiyoshi, Xiaohui Liu, Ayami Matsushima, Miki Shimohigashi, and Yasuyuki Shimohigashi
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚中央公民館(神奈川県平塚市)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Protein Constitutive Peptide Fragments to Inhibit Protein-Protein Interaction: Inhibitory Peptides as Molecular Probe for Clarification of Human Nuclear Receptor Activation Mechanism.2015

    • Author(s)
      Xiaohui Liu, Miki Shimohigashi, Ayami Matsushima, and Yasuyuki Shimohigashi
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚中央公民館(神奈川県平塚市)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Do the Estrogen Receptors Function as A Homodimer? Experimental Validation of Homodimerization by Inhibitory Peptides.2015

    • Author(s)
      Saya Sakito, Xiaohui Liu, Akina Fujiyama, Ayami Matsushima, and Yasuyuki Shimohigashi
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚中央公民館(神奈川県平塚市)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Comparative Analyses of the Ligand Binding Domain Secondary Structures of Human Nuclear Receptors.2015

    • Author(s)
      Yutaka Matsuyama, Hirokazu Nishimura, Xiaohui Liu, Ayami Matsushima, Yasuyuki Shimohigashi
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚中央公民館(神奈川県平塚市)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 痛み増強受容体ORL1のPhe269は受容体活性化における新規な分子スイッチ.2015

    • Author(s)
      武末祐貴・西村裕一・劉 暁輝・松島綾美・下東康幸
    • Organizer
      平成27年度日本生化学会九州支部例会
    • Place of Presentation
      九州大学国際ホール&システム生命科学府棟(福岡市)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] エストロゲン受容体 ERβ型の受容体活性化に必須なホモダイマー化の構造要因.2015

    • Author(s)
      﨑戸沙耶・藤山明菜・劉 暁輝・松島綾美・下東康幸
    • Organizer
      平成27年度日本生化学会九州支部例会
    • Place of Presentation
      九州大学国際ホール&システム生命科学府棟(福岡市)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自発活性化型核内受容体 SF1 が介添えして起こるビスフェノールAの エストロゲン受容体における著明な活性増強.2015

    • Author(s)
      佐藤俊介・劉 暁輝・松島綾美・下東康幸
    • Organizer
      平成27年度日本生化学会九州支部例会
    • Place of Presentation
      九州大学国際ホール&システム生命科学府棟(福岡市)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] ERRホモダイマーが協働して増強されるビスフェノールAのERαを介したエストロゲン様活性.2015

    • Author(s)
      劉 暁輝・池田 伸・松島綾美・下東康幸
    • Organizer
      平成27年度日本生化学会九州支部例会
    • Place of Presentation
      九州大学国際ホール&システム生命科学府棟(福岡市)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 雌雄で異なる概日性神経ペプチド遺伝子が誘導するビスフェノールA暴露マウスにおける低活動性症状.2015

    • Author(s)
      杉山真季子・梶山祥太・亀田朋典・斎藤辰弥・内村恵梨子・元松雄大・劉 暁輝・松島綾美・下東美樹・下東康幸
    • Organizer
      平成27年度日本生化学会九州支部例会
    • Place of Presentation
      九州大学国際ホール&システム生命科学府棟(福岡市)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] ビスフェノールA食餌ショウジョウバエが示す多動性症状と時計遺伝子発現パターンの変化,2015

    • Author(s)
      松尾文香・梅野翔太郎・徳丸飛鳥・中村将行・住吉美保・劉 暁輝・松島綾美・下東美樹・下東康幸
    • Organizer
      平成27年度日本生化学会九州支部例会
    • Place of Presentation
      九州大学国際ホール&システム生命科学府棟(福岡市)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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