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Development of species/site-specific drug delivery technology using carrier particles and their application to agriculture field

Research Project

Project/Area Number 15H01745
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental engineering and reduction of environmental burden
Research InstitutionOsaka Prefecture University

Principal Investigator

Nomura Toshiyuki  大阪府立大学, 工学(系)研究科(研究院), 准教授 (00285305)

Co-Investigator(Kenkyū-buntansha) 谷 修治  大阪府立大学, 生命環境科学研究科, 准教授 (80405357)
徳本 勇人  大阪府立大学, 理学(系)研究科(研究院), 講師 (70405348)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2017: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2016: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2015: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Keywordsキャリア粒子 / DDS / 植物 / イメージング
Outline of Final Research Achievements

In this study, the delivery of target substances to cells with cell walls was investigated using carrier particles. As a result, it was found that biodegradable polymer particles were taken into plant pathogens. In addition, it was revealed that encapsulation of pesticide in the carrier particle improved the inhibition of infection by plant pathogens. Furthermore, it was found that proteins and polysaccharides can be delivered to plant cells by using polystyrene particles (particle size 30 nm) adsorbing cationic lipids as carrier particles.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (33 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (31 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results)

  • [Journal Article] Comparison of the cytotoxic effect of polystyrene latex nanoparticles on planktonic cells and bacterial biofilms2016

    • Author(s)
      T. Nomura, E. Fujisawa, S. Itoh, Y. Konishi
    • Journal Title

      J. Nanopart. Res.

      Volume: 18 Issue: 6 Pages: 157-157

    • DOI

      10.1007/s11051-016-3471-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cytotoxicity and colloidal behavior of polystyrene latex nanoparticles toward filamentous fungi in isotonic solutions2016

    • Author(s)
      T. Nomura, S. Tani, M. Yamamoto, T. Nakagawa, S. Toyoda, E. Fujisawa, A. Yasui, Y. Konishi
    • Journal Title

      Chemosphere

      Volume: 149 Pages: 84-90

    • DOI

      10.1016/j.chemosphere.2016.01.091

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 粒子-細胞間に働く相互作用力の評価とその利用2018

    • Author(s)
      野村俊之
    • Organizer
      NEPTIS-26
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 原子間力顕微鏡を用いた粒子-植物細胞に働く相互作用力の直接評価2018

    • Author(s)
      田川花菜,小西康裕,野村俊之
    • Organizer
      第20回化学工学会学生発表会(東広島大会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Disease control of Phytophthora infestans using cyazofamid loaded PLGA nanoparticles2017

    • Author(s)
      K. Fukamachi, S. Tani, Y. Konishi, T. Nomura
    • Organizer
      7th Asian Particle Technology Symposium (APT 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Eco-toxicity of polystyrene nanoparticles on the growth of methanogen2017

    • Author(s)
      R. Chen, Y. Konishi, T. Nomura
    • Organizer
      7th Asian Particle Technology Symposium (APT 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Delivery of carrier nanoparticles into tobacco BY-2 cells2017

    • Author(s)
      Y. Yuasa, Y. Konishi, T. Nomura
    • Organizer
      7th Asian Particle Technology Symposium (APT 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cytotoxicity of polymer nanoparticles toward methanogen2017

    • Author(s)
      R. Chen, Y. Konishi, T. Nomura
    • Organizer
      Joint Symposium of Asia Five Universities
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 農薬封入キャリア粒子を用いた植物病原菌の防除2017

    • Author(s)
      野村俊之,深町一仁
    • Organizer
      第107回テクノラボツアー
    • Related Report
      2017 Annual Research Report
  • [Presentation] 原子間力顕微鏡を用いた植物細胞に働く相互作用力の直接測定2017

    • Author(s)
      田川花菜,小西康裕,野村俊之
    • Organizer
      2017年度粉体工学会秋期研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 薬物封入粒子を利用して食料問題に貢献!2017

    • Author(s)
      野村俊之
    • Organizer
      APPIE産学官連携フェア2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 農薬封入キャリア粒子を用いた植物病原菌の防除2017

    • Author(s)
      南浦茉奈,小西康裕,野村俊之
    • Organizer
      化学工学会金沢大会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 動物細胞と植物細胞へのナノ粒子の取込現象の比較2017

    • Author(s)
      長井このみ,小西康裕,野村俊之
    • Organizer
      化学工学会金沢大会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 植動植物細胞におけるキャリア粒子の取込現象の相違2017

    • Author(s)
      長井このみ,小西康裕,野村俊之
    • Organizer
      第19回化学工学会学生発表会(大阪大会)
    • Place of Presentation
      大阪大学(豊中市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 農薬封入キャリア粒子を用いたウリ炭疽病菌の防除2017

    • Author(s)
      南浦茉奈,谷 修治,小西康裕,野村俊之
    • Organizer
      第19回化学工学会学生発表会(大阪大会)
    • Place of Presentation
      大阪大学(豊中市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 植物細胞と動物細胞へのナノ粒子の取込現象の比較2016

    • Author(s)
      長井このみ,湯浅友貴,小西康裕,野村俊之
    • Organizer
      2016年度粉体工学会秋期研究発表会
    • Place of Presentation
      東京ビッグサイト(東京都江東区)
    • Year and Date
      2016-11-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 糸状菌を用いた高分子ナノ粒子の取込現象の評価2016

    • Author(s)
      野村俊之,山本 亮,中川拓実,谷 修治,小西康裕
    • Organizer
      日本植物学会第80回大会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] PLGAナノ粒子のタバコ培養細胞への導入2016

    • Author(s)
      湯浅友貴,小西康裕,野村俊之
    • Organizer
      日本植物学会第80回大会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] メタラキシル封入PLGAナノ粒子を用いた植物病原菌P. infestansの防除2016

    • Author(s)
      深町一仁,谷 修治,小西康裕,野村俊之
    • Organizer
      日本植物学会第80回大会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] メタン生成古細菌の増殖に及ぼすポリスチレンナノ粒子の影響2016

    • Author(s)
      陳 栄, 小西康裕, 野村俊之
    • Organizer
      第48回化学工学会秋季大会
    • Place of Presentation
      徳島大学(徳島市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 薬物送達用キャリアナノ粒子の種々の細胞への導入2016

    • Author(s)
      野村俊之,湯浅友貴,深町一仁,弓山翔平,中川拓実,小西康裕
    • Organizer
      第52回粉体工学会夏期シンポジウム
    • Place of Presentation
      ひょうご共済会館(神戸市)
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] メタン生成古細菌に及ぼすPSLナノ粒子の毒性影響2016

    • Author(s)
      陳 栄,小西康裕,野村俊之
    • Organizer
      第18回化学工学会学生発表会(福岡大会)
    • Place of Presentation
      福岡大学(福岡県福岡市)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] キャリアナノ粒子のタバコBY-2細胞への導入2016

    • Author(s)
      湯浅 友貴,小西康裕,野村俊之
    • Organizer
      第18回化学工学会学生発表会(福岡大会)
    • Place of Presentation
      福岡大学(福岡県福岡市)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 農薬内包PLGA粒子を用いた植物病原菌の防除2016

    • Author(s)
      深町一仁,谷 修治,小西康裕,野村俊之
    • Organizer
      第18回化学工学会学生発表会(福岡大会)
    • Place of Presentation
      福岡大学(福岡県福岡市)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生体の界面現象を制御して食料問題を解決!2015

    • Author(s)
      野村俊之
    • Organizer
      APPIE産学官連携フェア2015
    • Place of Presentation
      インテックス大阪(大阪府大阪市)
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] ポリスチレンナノ粒子がメタン生成古細菌に及ぼす毒性評価2015

    • Author(s)
      陳 栄,小西康裕,野村俊之
    • Organizer
      2015年度粉体工学会秋期研究発表会
    • Place of Presentation
      大阪南港ATC(大阪府大阪市)
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] タバコ培養細胞へのナノ粒子の導入2015

    • Author(s)
      湯浅 友貴,小西康裕,野村俊之
    • Organizer
      2015年度粉体工学会秋期研究発表会
    • Place of Presentation
      大阪南港ATC(大阪府大阪市
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 農薬封入キャリア粒子を用いた植物病原菌の防除2015

    • Author(s)
      深町一仁,小西康裕,野村俊之
    • Organizer
      2015年度粉体工学会秋期研究発表会
    • Place of Presentation
      大阪南港ATC(大阪府大阪市
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Eco-toxicity of polystyrene latex nanoparticles toward biofilm2015

    • Author(s)
      E. Fujisawa, S. Itoh, Y. Konishi, T. Nomura
    • Organizer
      The 6th Asian Particle Technology Symposium (APT2015)
    • Place of Presentation
      COEX, Seoul, Korea
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cytotoxicity of functionalized polystyrene latex nanoparticles toward filamentous fungi2015

    • Author(s)
      T. Nakagawa, M. Yamamoto, S. Tani, Y. Konishi, T. Nomura
    • Organizer
      The 6th Asian Particle Technology Symposium (APT2015)
    • Place of Presentation
      COEX, Seoul, Korea
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 微生物・植物細胞へのナノ粒子の付着・取込現象2015

    • Author(s)
      野村俊之
    • Organizer
      第66回コロイドおよび界面化学討論会
    • Place of Presentation
      鹿児島大学(鹿児島県鹿児島市)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 酸化亜鉛ナノ粒子が根の伸長成長に及ぼす影響2015

    • Author(s)
      中島淑乃,村田森応,井渕加奈,宮崎順平,栗山雄太,竹田恵美,野村俊之,徳本勇人
    • Organizer
      日本植物学会第79回大会
    • Place of Presentation
      新潟コンベンションセンター(新潟県新潟市)
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 酸化亜鉛ナノ粒子が細胞増殖に及ぼす影響2015

    • Author(s)
      中島淑乃,竹田恵美,野村俊之,徳本勇人
    • Organizer
      日本植物学会第79回大会
    • Place of Presentation
      新潟コンベンションセンター(新潟県新潟市)
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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