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Mechanisms of inflammation control in functional phytochemicals: Counterplans against lifestyle-related diseases based on chronic inflammation

Research Project

Project/Area Number 15H01767
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits
Research InstitutionTokyo University of Agriculture

Principal Investigator

UEHARA Mariko  東京農業大学, 応用生物科学部, 教授 (20211071)

Co-Investigator(Kenkyū-buntansha) 高橋 信之  東京農業大学, 応用生物科学部, 准教授 (50370135)
井上 博文  東京農業大学, 応用生物科学部, 助教 (10639305)
Co-Investigator(Renkei-kenkyūsha) KATSUMATA Shin-ichi  東京農業大学, 応用生物科学部, 准教授 (10424681)
Research Collaborator Felix Angelina DR.  University of the Philippines Los Baños, Institute of Human Nutrition and Food, College of Human Ecology, Associate Professor
IKUSHIRO Shin-ichi  富山県立大学, 工学研究科, 教授
MUROTA Kaeko  島根大学, 生物資源科学部, 教授
KATSUMATA Rie (TSUBOI Rie)  東京農業大学, 応用生物科学部, 助手
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥41,340,000 (Direct Cost: ¥31,800,000、Indirect Cost: ¥9,540,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Keywordsファイトケミカル / ポリフェノール / 含硫化合物 / 炎症制御 / ロコモティブシンドローム / メタボリックシンドローム / 破骨細胞 / シグナル伝達 / フィトケミカル / 骨粗鬆症 / 植物性機能物質(フィトケミカル) / 生理活性物質
Outline of Final Research Achievements

In this study, we focused on the anti-inflammatory effects of functional phytochemicals, and aimed at simultaneous prevention of lifestyle-related diseases caused by chronic inflammation, especially locomotive/metabolic syndromes. First, we screened anti-inflammatory effects of phytochemicals by using osteoclasts (OC) in vitro, since OC is activated in inflammatory condition. Equol enantiomers, isoflavone metabolites, and suforaphane, a sulfur-containing compound, were found as effective compounds for anti-osteoclastogenesis. We determined the detailed mechanism in OC, and examined the anti-inflammatory effects of those phytochemicals in chronic inflammatory disease modeled animals. Regarding anti-metabolic syndrome, we used black/brown rice extracts, which involved anthocyanins and other ingredients as physiological active substances. The extracts inhibited hepatic fat accumulation via activation of PPAR-alpha in obese and type II diabetes model mouse with high fat diet intake.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (32 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (18 results) (of which Int'l Joint Research: 9 results,  Invited: 8 results) Book (1 results) Remarks (3 results)

  • [Int'l Joint Research] University of the Philippines Los Banos(Philippines)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of the Philippines Los Banos(Philippines)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Flavonoid metabolism: the interaction of metabolites and gut microbiota.2018

    • Author(s)
      Murota K, Nakamura Y, Uehara M.
    • Journal Title

      Biosci Biotechnol Biochem.

      Volume: 82 Issue: 4 Pages: 600-610

    • DOI

      10.1080/09168451.2018.1444467

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracts of black and brown rice powders improve hepatic lipid accumulation via the activation of PPARα in obese and diabetic model mice.2017

    • Author(s)
      Felix AD, Takahashi N, Takahashi M, Katsumata-Tsuboi R, Satoh R, Soon Hui T, Miyajima K, Nakae D, Inoue H, Uehara M.
    • Journal Title

      Biosci Biotechnol Biochem.

      Volume: 81 Issue: 11 Pages: 2209-2211

    • DOI

      10.1080/09168451.2017.1372178

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sulforaphene attenuates multinucleation of pre-osteoclasts by suppressing expression of cell-cell fusion-associated genes DC-STAMP, OC-STAMP, and Atp6v0d2.2017

    • Author(s)
      Takagi T, Inoue H, Takahashi N, Katsumata-Tsuboi R, Uehara M.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 81 Issue: 6 Pages: 1220-1223

    • DOI

      10.1080/09168451.2017.1281729

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sulforaphane inhibits osteoclast differentiation by suppressing the cell-cell fusion molecules DC-STAMP and OC-STAMP.2017

    • Author(s)
      Takagi T, Inoue H, Takahashi N, Katsumata-Tsuboi R, Uehara M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 483 Issue: 1 Pages: 718-724

    • DOI

      10.1016/j.bbrc.2016.12.075

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Kanamycin inhibits daidzein metabolism and abilities of the metabolites to prevent bone loss in ovariectomized mice.2017

    • Author(s)
      Katsumata S, Fujioka M, Fujii S, Takeda K, Ishimi Y, Uehara M.
    • Journal Title

      BMC Res. Notes

      Volume: 9 Issue: 1 Pages: 334-334

    • DOI

      10.1186/s13104-016-2139-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A combination of soy isoflavones and cello-oligosaccharides changes equol/O-desmethylangolensin production ratio and attenuates bone fragility in ovariectomized mice.2016

    • Author(s)
      Fujii S, Takahashi N, Inoue H, Katsumata S, Kikkawa Y, Machida M, Ishimi Y, Uehara M.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 80 Issue: 8 Pages: 1632-1635

    • DOI

      10.1080/09168451.2016.1184559

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of Nrf2/Keap1 Signaling and Autophagy Induction against Oxidative Stress in Heart in Iron Deficiency2015

    • Author(s)
      Hirofumi Inoue, Ken-Ichi Kobayashi, Moussa Ndong, Yuji Yamamoto, Shi-Ichi Katsumata, Kazuharu Suzuki, Mariko Uehara
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 60 Issue: 8 Pages: 1-3

    • DOI

      10.1080/09168451.2015.1018125

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of Dietary Calcium Supplementation on Bone Metabolism, Kidney Mineral Concentrations, and Kidney Function in Rats Fed a High-Phosphorus Diet.2015

    • Author(s)
      Katsumata S, Matsuzaki H, Uehara M, Suzuki K.
    • Journal Title

      J. Nutr. Sci. Vitaminol.

      Volume: 61 Issue: 2 Pages: 195-200

    • DOI

      10.3177/jnsv.61.195

    • NAID

      130005074120

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Prebiotics and antibiotics affect soy isoflavone metabolism and bone health.2017

    • Author(s)
      Uehara M
    • Organizer
      2017 KoSFoST International Symposium & Annual Meeting (Jeju, Korea)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 動脈硬化性疾患発症リスクとしての食後高脂血症の食品成分による改善2017

    • Author(s)
      高橋 信之、上原 万里子
    • Organizer
      日本骨代謝学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 骨粗鬆症予防におけるフィトケミカルの有効性2017

    • Author(s)
      井上 博文
    • Organizer
      第15回日本機能性食品医用学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] レスベラトロールの食後高脂血症に対する作用メカニズムの解析2017

    • Author(s)
      高橋 真美、佐藤 綾、勝間田 理恵、井上 博文、中田 理恵子、井上 裕康、河田 照雄、室田 佳恵子、上原 万里子、高橋 信之
    • Organizer
      第71回 日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高齢化する女性の健康を考える2017

    • Author(s)
      上原万里子
    • Organizer
      第19回 脂質栄養シンポジウム ―健康寿命の延伸―
    • Place of Presentation
      星稜会館(東京・千代田区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Equol鏡像異性体の再吸収動態と骨量減少抑制作用の差異2016

    • Author(s)
      藤井俊吾、生城真一、室田佳恵子、太田篤胤、井上博文、高橋信之、上原万里子
    • Organizer
      第21回 日本フードファクター学会 学術集会
    • Place of Presentation
      富山国際会議場(富山県・富山市)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] SulforaphaneはSTAT1を介して破骨細胞融合因子(DC-STAMP,OC-STAMP)を阻害する2016

    • Author(s)
      髙木智弘、井上博文、勝間田(坪井)理恵、高橋信之、上原万里子
    • Organizer
      第21回 日本フードファクター学会 学術集会
    • Place of Presentation
      富山国際会議場(富山県・富山市)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] オレウロペイン代謝産物hydroxytyrosolによる破骨細胞分化抑制メカニズム2016

    • Author(s)
      井上 博文、勝間田(坪井) 理恵、高橋 信之、上原 万里子
    • Organizer
      第10回 日本ポリフェノール学会 学術集会
    • Place of Presentation
      芝浦工業大学 豊洲キャンパス(東京都・江東区)
    • Year and Date
      2016-08-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sulforaphaneの続発性骨粗鬆症に対する有効性および作用機序の検討2016

    • Author(s)
      髙木智弘、井上博文、高橋信之、牛田悠介、菅沼大行、上原万里子
    • Organizer
      第70回 日本栄養・食糧学会大会
    • Place of Presentation
      神戸ポートピアホテル・武庫川女子大学 中央キャンパス(兵庫県・神戸市および西宮市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Food Diversification in Japan~Update of the Japanese Regulation for Health Food~2016

    • Author(s)
      Uehara M.
    • Organizer
      12th International Conference on Liberal Arts and Frontier Technologies
    • Place of Presentation
      Kyungpook National University, Daeg, Korea
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Beyond antioxidative and anti-inflammatory activities of phytochemicals inhibit osteoclastogenesis.2015

    • Author(s)
      Uehara M, Inoue H, Takahashi N.
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
    • Place of Presentation
      Sheraton Waikiki Hotel, Honolulu, Hawaii, USA.
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Comparative activities of isoflavone metabolites on osteoclastogenesis in vitro and bone loss in vivo.2015

    • Author(s)
      Uehara M, Inoue H, Takahashi N.
    • Organizer
      6th International Conference on Food Factors (ICoFF2015)
    • Place of Presentation
      Coex, Seoul, Korea
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Whole cell-dependent production of equol metabolites using genetically engineered budding yeast.2015

    • Author(s)
      Ikushiro S, Kataoka M, Nishikawa M, Yasuda K, Murota K, Uehara M, Kamakura M, Sakaki T.
    • Organizer
      6th International Conference on Food Factors (ICoFF2015)
    • Place of Presentation
      Coex, Seoul, Korea
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A combination of soy isoflavones and cellooligosaccharides improves equol production and bone fragility in ovariectomized mice.2015

    • Author(s)
      Fujii S, Inoue H, Takahashi N, Kikkawa Y, Machida M, Uehara M.
    • Organizer
      6th International Conference on Food Factors (ICoFF2015)
    • Place of Presentation
      Coex, Seoul, Korea
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Isothiocyanates suppressed the osteoclast differentiation by decreasing master regulator of osteoclast fusion factor DC-STAMP.2015

    • Author(s)
      Takagi T, Inoue H, Takahashi N, Uehara M.
    • Organizer
      6th International Conference on Food Factors (ICoFF2015)
    • Place of Presentation
      Coex, Seoul, Korea
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bone-sparing effects of phytochemicals in vitro and in rodent models of osteoporosis.2015

    • Author(s)
      Uehara M, Inoue H, Takahashi N.
    • Organizer
      12th Asian Congress of Nutrition (ACN2015)
    • Place of Presentation
      Pacifico Yokohama, Kanagawa, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sulforaphene, sulforaphene and erucin, sulfur containing compounds, inhibit osteoclasts differentiation via down-regulating cell-cell fusion molecules associated to osteoclast differentiation.2015

    • Author(s)
      Takagi T, Inoue H, Takahashi N, Uehara M.
    • Organizer
      12th Asian Congress of Nutrition (ACN2015)
    • Place of Presentation
      Pacifico Yokohama, Kanagawa, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differences in effects of equol enantiomers in vivo and in vitro.2015

    • Author(s)
      Fujii S, Inoue H, Takahashi N, Uehara M.
    • Organizer
      12th Asian Congress of Nutrition (ACN2015)
    • Place of Presentation
      Pacifico Yokohama, Kanagawa, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] 食品因子による栄養機能制御(第14章 骨・脂質・糖代謝を制御するポリフェノール)2015

    • Author(s)
      上原万里子(芦田均・立花宏文・原 博 責任編集)
    • Total Pages
      283
    • Publisher
      建帛社
    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京農業大学 応用生物科学部 食品安全健康学科 生理機能学研究室

    • URL

      http://nodaiweb.university.jp/physioly-and-metabolism/project.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京農業大学 応用生物科学部 食品安全健康学科 生理機能学研究室

    • URL

      http://nodaiweb.university.jp/physioly-and-metabolism/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京農業大学 応用生物科学部 食品安全健康学科 生理機能学研究室 (研究業績)

    • URL

      http://nodaiweb.university.jp/physioly-and-metabolism/project.html

    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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