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The preventive effects of exercise + milk product intake on lifestyle-related diseases and heat illness: the establishment of remote research system on a large population of subjects

Research Project

Project/Area Number 15H01830
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionShinshu University

Principal Investigator

Nose Hiroshi  信州大学, 学術研究院医学系, 教授 (40128715)

Co-Investigator(Kenkyū-buntansha) 樋口 京一  信州大学, 学術研究院医学系, 教授 (20173156)
上條 義一郎  和歌山県立医科大学, 医学部, 准教授 (40372510)
谷口 俊一郎  信州大学, 学術研究院医学系, 教授 (60117166)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2017: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2016: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2015: ¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
Keywords運動処方 / インターバル速歩 / 乳製品摂取 / 生活習慣病予防 / 熱中症予防 / 遺伝子修飾 / 血漿量 / インシュリン / 生活習慣病 / 要介護 / 熱中症
Outline of Final Research Achievements

In our previous studies, we suggested that lifestyle-related diseases and heat illness were mainly caused by muscle atrophy with advancing aging. Further, we suggested that the regimen of "interaval walking traiing + milk product intake" was effective to increase physical fitness, prevent lifestyle-related diseases, and improve body temperature regulation in middle-aged and older subjects. Therefore, in the present study, we examined the effects of the regimen in patients with lifestyle-related diseases while fousing not only on the symptoms of diseases but also on the epigenetics. We have established a remote research system which enables us to accomplish these on a large population of subjects.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (52 results)

All 2018 2017 2016 2015

All Journal Article (18 results) (of which Peer Reviewed: 18 results,  Acknowledgement Compliant: 6 results,  Open Access: 6 results) Presentation (21 results) (of which Int'l Joint Research: 6 results,  Invited: 13 results) Book (10 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Barometric pressure change and heart rate response during sleeping at 3000m2018

    • Author(s)
      Horiuchi M, Endo J, Handa Y, and Nose H
    • Journal Title

      Int J Biometeorol

      Volume: - Issue: 5 Pages: 909-912

    • DOI

      10.1007/s00484-017-1487-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of dried tofu supplementation during interval walking training on the methylation of NFKB2 gen in the whole blood of older women2018

    • Author(s)
      Morikawa M, Nakano S, Mitsui N, Murasawa H, Masuki S, and Nose H
    • Journal Title

      J Physiol Sci

      Volume: - Issue: 6 Pages: 749-757

    • DOI

      10.1007/s12576-017-0589-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Seasonal influence on adherence to and effects of an interval walking training program on sedentary female college students in Japan2018

    • Author(s)
      Tanabe A, Masuki S, Nemoto K, and Nose H
    • Journal Title

      Int J Biometeorol

      Volume: 62 Issue: 4 Pages: 643-654

    • DOI

      10.1007/s00484-017-1473-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged deppressive women: randomized, double-blind, crossover pilot srudy2018

    • Author(s)
      Suzuki H, Masuki S, Morikawa A, Ogawa Y, Kamijo Y, Takahashi K, Nakajima M, and Nose H
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 7151-7151

    • DOI

      10.1038/s41598-018-25452-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of postural change from supine to head-up tilt on the skin sympathetic nerve activity component synchronised with the cardiac cycle in warmed men.2017

    • Author(s)
      Ogawa Y, Kamijo YI, Ikegawa S, Masuki S, Nose H
    • Journal Title

      The Journal of Physiology

      Volume: 595 Issue: 4 Pages: 1185-1200

    • DOI

      10.1113/jp273281

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of milk product intake on thigh muscle strength and NFkB gene methylation during home-based interval walking training in older women: a randomized controlled study2017

    • Author(s)
      Masuki S, Nishida K, Hashimoto S, Morikawa M, Takasugi S, Nagata M, Taniguchi S, Rokutan K, and Nose H
    • Journal Title

      PLoS ONE,

      Volume: 12 Issue: 5 Pages: e0176757-e0176757

    • DOI

      10.1371/journal.pone.0176757

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interval walking training and nutritional intake to increase plasma volume in elderly2017

    • Author(s)
      Uchida K, Kamijo Y, Ikegawa S, Hamada K, Masuki S, and Nose H
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 50 Issue: 1 Pages: 151-158

    • DOI

      10.1249/mss.0000000000001416

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of carbohydrate-electrolyte beverages ingestion on heart rate response while climbing Mt. Fiji at 3,000m2017

    • Author(s)
      Horiuchi M, Endo J, Kondo K, Uno T, Morikawa M, and Nose H
    • Journal Title

      BioMed Res Int

      Volume: 2017 Pages: 1-7

    • DOI

      10.1155/2017/3919826

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 老年医学の展望:0歳若返る!「インターバル速歩」-生活習慣病・介護予防のための新しい運動処方システム-2017

    • Author(s)
      能勢 博
    • Journal Title

      日本老年医学会雑誌

      Volume: 54 Pages: 10-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interval walking training can increase physical fitness in middle-aged and older people2017

    • Author(s)
      Masuki S, Morikawa M, and Nose H
    • Journal Title

      Exerc Sport Sci Rev

      Volume: 45 Issue: 3 Pages: 154-162

    • DOI

      10.1249/jes.0000000000000113

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older women.2016

    • Author(s)
      Masuki S, Morita A, Kamijo Y, Ikegawa S, Kataoka Y, Ogawa Y, Sumiyoshi E, Takahashi K, Tanaka T, Nakajima M, Nose H.
    • Journal Title

      J Appl Physiol

      Volume: 120 Issue: 1 Pages: 87-96

    • DOI

      10.1152/japplphysiol.00582.2015

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Target intensity and interval walking training in water to enhance physical fitness in middle-aged and older women: a randomised controlled study.2016

    • Author(s)
      Handa S, Masuki S, Ohshio T, Kamijo Y, Takamata A, Nose H.
    • Journal Title

      Eur J Appl Physiol.

      Volume: 116 Issue: 1 Pages: 203-215

    • DOI

      10.1007/s00421-015-3267-9

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of hypervolemia bu protein and glucose supplementation during aerobic training on thermal and arterial pressure regulations in hypertensive older men2016

    • Author(s)
      Kataoka Y, Kamijo Y, Ogawa Y, Sumitoshi E, Nakae M, Ikegawa S, Manabe K, Morikawa M, Nagata M, Takasugi S, Masuki S, and Nose H
    • Journal Title

      J. Appl. Physiol.

      Volume: 121 Issue: 4 Pages: 1021-1031

    • DOI

      10.1152/japplphysiol.00033.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] スポーツ、汗と電解質異常2016

    • Author(s)
      能勢 博、片岡由布子、小川 雄、増木静江
    • Journal Title

      腎と透析

      Volume: 80 Pages: 315-320

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] フレイルの予防を目的としたウォーキングの有効性2016

    • Author(s)
      能勢 博、半田秀一、森川真悠子、増木静江
    • Journal Title

      理学療法

      Volume: 33 Pages: 1102-1110

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The factors affecting adherence to a long-term interval walking training program in middle-aged and older people2015

    • Author(s)
      Masuki S, Mori M, Tabara Y, Sakurai A, Hashimoto S, Morikawa M, Miyagawa K, Sumiyoshi E, Miki T, Higuchi K, and Nose H
    • Journal Title

      J. Appl. Physiol.

      Volume: 118 Issue: 5 Pages: 595-603

    • DOI

      10.1152/japplphysiol.00819.2014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] NFkB2 gene as anoble candidate epidemiologically responding to interval walking training.2015

    • Author(s)
      Zhang Y, Hashimoto S, Fujii C, Hida S, Ito K, Matsumura T, Sakaizawa T, Morikawa M, Masuki S, Nose H, Higuchi K, Nakajima K, Taniguchi S
    • Journal Title

      Int. J. Sports. Med.

      Volume: in press Issue: 09 Pages: 769-775

    • DOI

      10.1055/s-0035-1547221

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vasopressin V1a receptor gene and voluntary exercise: Insights from humans and animal models2015

    • Author(s)
      Masuki S, Sumiyoshi E, Morikawa M, and Nose H
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 4 Issue: 3 Pages: 271-278

    • DOI

      10.7600/jpfsm.4.271

    • NAID

      130005091347

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] インターバル速歩+乳製品摂取の生活習慣病改善効果、シンポジウム「食べること・動くことが人生を変える2018

    • Author(s)
      増木静江、内田晃司、森川真悠子、能勢 博
    • Organizer
      第95回日本生理学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 5ヶ月間のインターバル速歩が中高年者の認知機能に及ぼす効果2017

    • Author(s)
      降幡真由佳、森川真悠子、林良一、冨田和優美、増木静江、能勢 博
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 中高年者インターバル速歩10年継続の体力維持・向上効果-ドロップアウト者との比較-2017

    • Author(s)
      森川真悠子、増木静江、古旗俊一、下平博和、降幡真由佳、能勢 博
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] インターバル速歩トレーニング+高圧化高邁摂取による生活習慣病予防効果2017

    • Author(s)
      相田隆道、増木静江、内田晃司、真鍋憲正、森川真悠子、降幡真由佳、藤田智之、能勢 博
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] インターバル速歩+牛乳・糖質摂取は高血糖・高血圧症状の改善を促進する2017

    • Author(s)
      内田晃司、増木静江、森川真悠子、降幡真由佳、真鍋憲正、小川 雄、片岡由布子、相田隆道、中野さくら、能勢 博
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 熱中症予防アラーム付消防服の開発2017

    • Author(s)
      小川雄, 木村祐、安光玲、片岡由布子、内田晃司、眞鍋憲正、増木静江、能勢博
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 10歳若返る歩行術「インターバル速歩」-その背景と効果のエビデンス2017

    • Author(s)
      能勢 博
    • Organizer
      第49回日本動脈硬化学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Effects of 5-aminolevulinic acid with iron supplementation on respiratory response to exercise and interval walking training achievement in middle-aged depressive women2016

    • Author(s)
      Suzuki H, Masuki S, Morikawa A, Ogawa Y, Kamijo Y, Takahashi K, Nakajima M, and Nose H
    • Organizer
      The 4th International ALA and Porphyrin Symposium
    • Place of Presentation
      Nagasaki, Nagasaki University
    • Year and Date
      2016-12-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Interval walking training to prevent age-associated declines in physical fitness and lifestyle-related diseases2016

    • Author(s)
      Masuki S, Morikawa M, and Nose H
    • Organizer
      The 6th International Sports Science Network Forum in Nagano 2016
    • Place of Presentation
      Matsumoto, otel Buena Vista
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Interval walking training program for sedentary female college students: seasonal influence on the adherence.2016

    • Author(s)
      Tanabe A, Masuki S, Nemoto K, Nose H
    • Organizer
      The 6th International Sports Science Network Forum in Nagano 20
    • Place of Presentation
      Matsumoto, Hotel Buena Vista
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A New Device to Estimate Vo2 during Cycling on inclines by Accelerometry and Barometry.2016

    • Author(s)
      Ikegawa S, Takahashi Y, Kmaijo Y, Okada Y, Miyagawa K, Morikawa M, Genno H, Masuki S, and Nose H
    • Organizer
      The 6th International Sports Science Network Forum in Nagano 2016
    • Place of Presentation
      Matsumoto, Hotel Buena Vista
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interval walking training over 10 years protects against age-associated declines in physical fitness.2016

    • Author(s)
      Morikawa M, Masuki S, Furuhata S, Shimodaira H, Furihata M, Nose H.
    • Organizer
      The 6th International Sports Science Network Forum in Nagano 2016,
    • Place of Presentation
      Matsumoto, Hotel Buena Vista
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] インターバル速歩+乳製品摂取の生活習慣病・介護予防効果2016

    • Author(s)
      増木静江、能勢 博
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 10歳若返る歩行術「インターバル速歩」―生活習慣病・介護予防のための新しい運動処方システム―2016

    • Author(s)
      能勢 博
    • Organizer
      日本リハ学会近畿地方会
    • Place of Presentation
      和歌山県JAビル(和歌山市)
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 10歳若返る!「インターバル速歩」―その背景と効果のエビデンス―2016

    • Author(s)
      能勢 博
    • Organizer
      第28回老年麻酔学会
    • Place of Presentation
      メルパルク長野(長野市)
    • Year and Date
      2016-02-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Impact of 5-aminolevulinic acid with iron suplementation on exercise efficiency and home-based walking training in older women2015

    • Author(s)
      Masuki S, Morita A, Kamijo Y, Ikegawa S, Kataoka Y, Ogawa Y, Sumiyoshi E, Takahashi K, Tanaka T, Nakajima M, and Nose H
    • Organizer
      The 3rd International ALA and Porphyrin Symposium
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] インターバルウォーキングの健康増進効果2015

    • Author(s)
      能勢 博
    • Organizer
      日本抗加齢学会
    • Place of Presentation
      東京大手サンケイプラザ(大手町)
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 歩き方を変えるだけで10歳若返る!-生活習慣病・介護予防のための新しい運動処方システム-2015

    • Author(s)
      能勢 博
    • Organizer
      日本繊維製品消費科学会
    • Place of Presentation
      京都市
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 運動と牛乳暑さに強い体づくり2015

    • Author(s)
      能勢 博
    • Organizer
      長野県介護福祉士会
    • Place of Presentation
      軽井沢プリンスホテル(軽井沢町)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 歩き方を変えるだけで10歳若返る!-生活習慣病・介護予防のための新しい運動処方システム-2015

    • Author(s)
      能勢 博
    • Organizer
      電子情報通信学会ASN研究会
    • Place of Presentation
      メルパルク長野(長野市)
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 歩き方を変えるだけで10歳若返る!-生活習慣病・介護予防のための新しい運動処方システム-2015

    • Author(s)
      能勢 博
    • Organizer
      第11回日本疲労学会総会・学術集会
    • Place of Presentation
      山口県総合保健会館(山口市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] もう山でバテない!インターバル速歩の威力2017

    • Author(s)
      能勢 博
    • Total Pages
      207
    • Publisher
      山と渓谷社
    • Related Report
      2017 Annual Research Report
  • [Book] やさしい生理学(改訂第7版)2017

    • Author(s)
      彼末一之、能勢 博
    • Total Pages
      328
    • Publisher
      南江堂
    • Related Report
      2017 Annual Research Report
  • [Book] 「早く歩く」人は、体も心も超健康!2016

    • Author(s)
      能勢 博
    • Total Pages
      198
    • Publisher
      三笠書房
    • Related Report
      2016 Annual Research Report
  • [Book] メリハリ歩行はいい!2016

    • Author(s)
      能勢 博
    • Total Pages
      186
    • Publisher
      こう書房
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Book] エビデンスに基づく身体活動の科学:疫学・分子生物学からのアプローチ2016

    • Author(s)
      能勢 博、森川真悠子、増木静江
    • Total Pages
      257
    • Publisher
      杏林書院
    • Related Report
      2016 Annual Research Report
  • [Book] 「早く歩く」人は、体も心も超健康!2016

    • Author(s)
      能勢 博
    • Total Pages
      198
    • Publisher
      三笠書房
    • Related Report
      2015 Annual Research Report
  • [Book] Vasopressin V1a receoptor gene and voluntary exercise in human and mice. In: Physical Activity, Exercise, Sedentary Behavior and Health2015

    • Author(s)
      Masuki S, Sumiyoshi E, and Nose H
    • Total Pages
      335
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] いくつになっても自分で歩ける!「筋トレ」ウォーキング2015

    • Author(s)
      能勢 博
    • Total Pages
      181
    • Publisher
      青春出版
    • Related Report
      2015 Annual Research Report
  • [Book] 「寝たきり」が嫌ならこのウォーキングに変えなさい2015

    • Author(s)
      能勢 博
    • Total Pages
      93
    • Publisher
      朝日新聞出版
    • Related Report
      2015 Annual Research Report
  • [Book] 図解 いくつになっても自分で歩ける!「筋トレ」ウォーキング2015

    • Author(s)
      能勢 博
    • Total Pages
      92
    • Publisher
      青春出版
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 自転車で坂道走行時にエネルギー消費量が測定できる加速度計と気圧計を搭載した装置およびエネルギー消費量推定方法2017

    • Inventor(s)
      能勢 博、池川茂樹、増木静江
    • Industrial Property Rights Holder
      能勢 博、池川茂樹、増木静江
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 暑熱環境の現場で使える携帯型発汗計2017

    • Inventor(s)
      能勢 博、小川 雄、増木静江
    • Industrial Property Rights Holder
      能勢 博、小川 雄、増木静江
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 生活習慣病を予防または改善するための高圧加工米2017

    • Inventor(s)
      藤田智之、能勢 博、増木静江
    • Industrial Property Rights Holder
      藤田智之、能勢 博、増木静江
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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