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Development of novel biomarkers on exercise, stress and aging and their functional analyses

Research Project

Project/Area Number 15H01833
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionWaseda University

Principal Investigator

Suzuki Katsuhiko  早稲田大学, スポーツ科学学術院, 教授 (80344597)

Co-Investigator(Kenkyū-buntansha) 秋本 崇之  早稲田大学, スポーツ科学学術院, 教授 (00323460)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2015: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
Keywords翻訳動態 / リボソームプロファイリング / 運動 / 骨格筋 / 老化 / 遺伝子ネットワーク / バイオマーカー / 骨格筋適応 / 共発現遺伝子ネットワーク解析 / ストレス / トレーニング / 網羅的翻訳動態解析 / 機能解析 / マウス / 共発現遺伝子ネットワーク / 翻訳 / 細胞 / マイクロRNA / 網羅的解析
Outline of Final Research Achievements

Using aging-model mice and young mice together with acute exercise model mice and endurance exercise model mice, grobal mRNA sequence and ribosome profiling were performed using next-generation sequencer. Changed variables and factors based on the analyses were further confirmed by real-time PCR and western blotting, and messages and proteins were quantified. In addition, gene network analyses were performed to capture changes at the system level of skeletal muscle, and found interesting genes and their potentially new functions.

Academic Significance and Societal Importance of the Research Achievements

運動や身体活動を担う骨格筋は総重量が生体の約50%にも達し、骨格筋で転写される骨格筋由来の分子は他の組織由来の分子に比べ多量に存在すると考えられる。老化モデルマウスや運動負荷マウスの骨格筋で網羅的に解析されてリストアップされた遺伝子は生活習慣病や老化の予防に役立つ可能性が高く、本研究ではバイオインフォマティクス的手法を用いて基礎研究レベルでの解析が行われ、新知見が得られた。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (17 results)

All 2018 2017 2016 2015 Other

All Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 9 results,  Acknowledgement Compliant: 6 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Cytokine Response to Exercise and Its Modulation2018

    • Author(s)
      K Suzuki
    • Journal Title

      Antioxidants

      Volume: 7 Issue: 1 Pages: 17-17

    • DOI

      10.3390/antiox7010017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Ingestion of Different Amounts of Carbohydrate after Endurance Exercise on Circulating Cytokines and Markers of Neutrophil Activation2018

    • Author(s)
      K Tanisaw, K Suzuki, S Ma, S Kondo, S Okugawa, M Higuchi
    • Journal Title

      Antioxidants

      Volume: 7 Issue: 4 Pages: 51-51

    • DOI

      10.3390/antiox7040051

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of endothelial microRNAs on blood pressure homeostasis2018

    • Author(s)
      S Oikawa, S Maeda, T Akimoto
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 7 Issue: 1 Pages: 41-45

    • DOI

      10.7600/jpfsm.7.41

    • NAID

      130006315805

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Titin Fragments in Urine in Response to Exercise-induced Muscle Damage2017

    • Author(s)
      K Kanda, J Sakuma, T Akimoto, Y Kawakami, K Suzuki
    • Journal Title

      PloS one

      Volume: 12 Issue: 7 Pages: 1-14

    • DOI

      10.1371/journal.pone.0181623

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exercise-Induced Inflammation during Different Phases of the Menstrual Cycle.2016

    • Author(s)
      Harumi Hayashida, Mayura Shimura, Kaoru Sugama, Kazue Kanda, Katsuhiko Suzuki
    • Journal Title

      Physiother Rehabil

      Volume: 1 Pages: 121-121

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Systemic Inflammation Mediates the Effects of Endotoxemia in the Mechanisms of Heat Stroke.2016

    • Author(s)
      Chin Leong Lim, Katsuhiko Suzuki
    • Journal Title

      Biol Med

      Volume: 9 Issue: 01 Pages: 376-376

    • DOI

      10.4172/0974-8369.1000376

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 運動によるサイトカインの動態と制御2016

    • Author(s)
      鈴木克彦
    • Journal Title

      日本未病システム学会雑誌

      Volume: 22 (1) Pages: 31-33

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Genome-Wide Analysis of Acute Endurance Exercise-Induced Translational Regulation in Mouse Skeletal Muscle2016

    • Author(s)
      Hiroaki Sako, Koichi Yada, and Katsuhiko Suzuki
    • Journal Title

      PLOS One

      Volume: 11 Issue: 2 Pages: e0148311-e0148311

    • DOI

      10.1371/journal.pone.0148311

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genome-wide Analysis of Acute Inflammatory and Anti-Inflammatory Responses in RAW264 Cells Suggests cis-Elements Associated with Translational Regulation2016

    • Author(s)
      Hiroaki Sako and Katsuhiko Suzuki
    • Journal Title

      Journal of Data Mining in Genomics & Proteomics

      Volume: 7 Issue: 02 Pages: 191-191

    • DOI

      10.4172/2153-0602.1000191

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effects of the menstrual cycle and acute aerobic exercise on cytokine levels.2015

    • Author(s)
      Hayashida H, Shimura M, Sugama K, Kanda K, Suzuki K.
    • Journal Title

      J Sports Med Doping Stud

      Volume: 6 Issue: 01 Pages: 173-173

    • DOI

      10.4172/2161-0673.1000173

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of exercise-induced muscle damage on muscle hardness evaluated by ultrasound real-time tissue elastography.2015

    • Author(s)
      Yanagisawa O, Sakuma J, Kawakami Y, Suzuki K, Fukubayashi T.
    • Journal Title

      SpringerPlus

      Volume: 4 Issue: 1 Pages: 308-308

    • DOI

      10.1186/s40064-015-1094-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 翻訳動態特異的な共発現遺伝子ネットワーク解析2018

    • Author(s)
      佐古博皓,秋本祟之,鈴木克彦
    • Organizer
      日本筋学会第四回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cytokine response to exercise and its modulation2017

    • Author(s)
      Katsuhiko Suzuki
    • Organizer
      13th Symposium of the International Society of Exercise and Immunology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Translation-specific gene network predicts novel gene functions2017

    • Author(s)
      Hiroaki Sako, Takayuki Akimoto, Katsuhiko Suzu
    • Organizer
      MIRAI seminar and Ageing workshops
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 翻訳動態特異的共発現ネットワークによる遺伝子の機能予測とその解析2017

    • Author(s)
      佐古博皓,秋本崇之,鈴木克彦
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 共発現遺伝子ネットワークによる遺伝子の機能予測とその解析2017

    • Author(s)
      佐古博皓,秋本崇之,鈴木克彦
    • Organizer
      第3回日本筋学会
    • Related Report
      2017 Annual Research Report
  • [Remarks] http://www.f.waseda.jp/katsu.suzu/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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