Development of versatile synthesis for fungal natural products by reconstitution of biosynthetic machinery
| Project/Area Number |
15H01835
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
南 篤志 北海道大学, 理学研究院, 准教授 (40507191)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2016: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2015: ¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
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| Keywords | 生合成 / 天然物 / テルペン / ペプチド / 麹菌 |
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| Outline of Final Research Achievements |
Using Aspergillus oryzae expression system, we have succeeded elucidation of enzymatic mechanism of several important natural products such as C20/C25-terpenes, ribosomal peptide and mushroom antibiotics. Especially, we proved the expression system is reliable for production of known and novel natural products (terpenoids) using uncharacterized biosynthetic gene clusters.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Focused genome mining of structurally related sesterterpenes: enzymatic formation of enantiomeric and diastereomeric products2017
Author(s)
Narita, K., Sato, H., Minami, A., Kudo, K., Gao, L., Liu, C., Ozaki, T., Kodama, M.., Lei, X., Taniguchi, T., Monde, K., Yamazaki, M., Uchiyama, M., Oikawa, H.
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Journal Title
Organic letters
Volume: 19
Issue: 24
Pages: 6696-6699
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi.2016
Author(s)
Y. Ye, A. Minami, Y. Igarashi, M. Izumikawa, M. Umemura, N. Nagano, M. Machida, T. Kawahara, K. Shin-ya, K. Gomi, H. Oikawa
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Journal Title
Angewandte Chemie-International Edition
Volume: 55
Issue: 28
Pages: 8072-8075
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Reconstitution of biosynthetic machinery for the synthesis of the highly elaborated indole diterpene Penitrem.2015
Author(s)
Liu, C., Tagami, K., Minami, A., Matsumoto, T., Frisvad, J.C., Suzuki, H., Ishikawa, J., Gomi, K., and Oikawa, H.
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Journal Title
Angew. Chem. Int. Ed.
Volume: 54
Issue: 19
Pages: 5748-5752
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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