Biosynthetic studies on complex natural products

• Project/Area Number: 15H01836
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomolecular chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: Abe Ikuro 東京大学, 大学院薬学系研究科(薬学部), 教授 (40305496)
• Co-Investigator(Kenkyū-buntansha): 淡川 孝義 東京大学, 大学院薬学系研究科(薬学部), 助教 (80609834) ; 中村 仁美 東京大学, 大学院薬学系研究科(薬学部), 助教 (90800657) ; 岡田 正弘 東京大学, 大学院薬学系研究科(薬学部), 准教授 (40377792) ; 松田 侑大 東京大学, 大学院薬学系研究科(薬学部), 特任助教 (10720766) ; 森 貴裕 東京大学, 大学院薬学系研究科(薬学部), 助教 (60734564)
• Co-Investigator(Renkei-kenkyūsha): MORITA Hiroyuki 富山大学, 和漢医薬学総合研究所, 教授 (20416663) ; SENDA Toshiya 大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 教授 (30272868)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥40,300,000 (Direct Cost: ¥31,000,000、Indirect Cost: ¥9,300,000); Fiscal Year 2017: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2016: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2015: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
• Keywords: 合成生物学 / 生合成 / 酵素 / 遺伝子 / 物質生産 / 構造生物学 / 反応機構

Outline of Final Research Achievements

We aimed to elucidate biosynthetic reaction mechanism of complex natural products. We succeeded in elucidating the details and structural basis of the biosynthetic machinery of various complex natural products such as telecidin B, calyculin A, antimycin, meroterpenoids, terpennoids, indole alkaloids, polyketides. We published the results in scientific journals.

Research Products

• [Int'l Joint Research] ジナン大学/上海有機化学研究所/武漢大学(中国)
• [Int'l Joint Research] ピッツバーグ大学(米国)
• [Int'l Joint Research] ボン大学(ドイツ)
• [Journal Article] Molecular insights into the Mg2+-dependent allosteric control of indole prenylation by aromatic prenyltransferase AmbP1 (2018)
  • Author(s): Abe Ikuro、Awakawa Takayoshi、Mori Takahiro、Nakashima Yu、Zhai Rui、Wong Chin Piow、Hillwig Matthew、Liu Xinyu
  • Journal Title: Angewandte Chemie International Edition Volume: 印刷中 Issue: 23 Pages: 6810-6813
  • DOI: 10.1002/anie.201800855
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage (2018)
  • Author(s): 2.Wang, G.-Q., Chen, G.-D., Qin, S.-Y., Hu, D., Awakawa, T., Li, S.-Y., Lv, J.-M., Wang, C.-X., Yao, X.-S., Abe, I., Gao, H.
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 1838-1838
  • DOI: 10.1038/s41467-018-04298-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis (2018)
  • Author(s): Nakashima Yu、Mori Takahiro、Nakamura Hitomi、Awakawa Takayoshi、Hoshino Shotaro、Senda Miki、Senda Toshiya、Abe Ikuro
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41467-017-02371-w
  • Peer Reviewed / Open Access
• [Journal Article] Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways (2018)
  • Author(s): Nakamura Hitomi、Matsuda Yudai、Abe Ikuro
  • Journal Title: Nat Prod Rep Volume: 35 Issue: 7 Pages: 633-645
  • DOI: 10.1039/c7np00055c
  • Peer Reviewed
• [Journal Article] Chimeric Terpene Synthases Possessing both Terpene Cyclization and Prenyltransfer Activities (2018)
  • Author(s): Mitsuhashi Takaaki、Abe Ikuro
  • Journal Title: ChemBioChem Volume: 19 Issue: 11 Pages: 1106-1114
  • DOI: 10.1002/cbic.201800120
  • Peer Reviewed
• [Journal Article] A Tryptophan Prenyltransferase with Broad Substrate Tolerance from Bacillus subtilis subsp. natto (2018)
  • Author(s): Abe Ikuro、Sugita Tomotoshi、Okada Masahiro、Nakashima Yu、Tian Tian
  • Journal Title: ChemBioChem Volume: 19 Issue: 13 Pages: 1396-1399
  • DOI: 10.1002/cbic.201800174
  • Peer Reviewed / Open Access
• [Journal Article] Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP3 (2017)
  • Author(s): Wong Chin Piow、Awakawa Takayoshi、Nakashima Yu、Mori Takahiro、Zhu Qin、Liu Xinyu、Abe Ikuro
  • Journal Title: Angewandte Chemie International Edition Volume: 57 Issue: 2 Pages: 560-563
  • DOI: 10.1002/anie.201710682
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis (2017)
  • Author(s): Mori Takahiro、Iwabuchi Taiki、Hoshino Shotaro、Wang Hang、Matsuda Yudai、Abe Ikuro
  • Journal Title: Nature Chemical Biology Volume: 13 Issue: 10 Pages: 1066-1073
  • DOI: 10.1038/nchembio.2443
  • Peer Reviewed
• [Journal Article] Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis (2017)
  • Author(s): Lv Jian-Ming、Hu Dan、Gao Hao、Kushiro Tetsuo、Awakawa Takayoshi、Chen Guo-Dong、Wang Chuan-Xi、Abe Ikuro、Yao Xin-Sheng
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 1644-1644
  • DOI: 10.1038/s41467-017-01813-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides (2017)
  • Author(s): Zhang, L., Hashimoto, T., Qin, B., Hashimoto, J., Kozone, I., Kawahara, T., Okada, M., Awakawa, T., Ito, T., Asakawa, Y., Ueki, M., Takahashi, S., Osada, H., Wakimoto, T., Ikeda, H., Shin-ya, K., Abe, I.
  • Journal Title: Angew. Chem. Int. Ed. Volume: 56 Issue: 7 Pages: 1740-1745
  • DOI: 10.1002/anie.201611371
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mechanistic Characterization of Two Chimeric Sesterterpene Synthases from Penicillium (2017)
  • Author(s): Mitsuhashi Takaaki、Rinkel Jan、Okada Masahiro、Abe Ikuro、Dickschat Jeroen S.
  • Journal Title: Chemistry - A European Journal Volume: 23 Issue: 42 Pages: 10053-10057
  • DOI: 10.1002/chem.201702766
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mycolic Acid Containing Bacterium Stimulates Tandem Cyclization of Polyene Macrolactam in a Lake Sediment Derived Rare Actinomycete (2017)
  • Author(s): Hoshino Shotaro、Okada Masahiro、Awakawa Takayoshi、Asamizu Shumpei、Onaka Hiroyasu、Abe Ikuro
  • Journal Title: Organic Letters Volume: 19 Issue: 18 Pages: 4992-4995
  • DOI: 10.1021/acs.orglett.7b02508
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Chimeric αβγ Diterpene Synthases Possessing both Type?II Terpene Cyclase and Prenyltransferase Activities (2017)
  • Author(s): Mitsuhashi Takaaki、Okada Masahiro、Abe Ikuro
  • Journal Title: ChemBioChem Volume: 18 Issue: 21 Pages: 2104-2109
  • DOI: 10.1002/cbic.201700445
  • Peer Reviewed / Open Access
• [Journal Article] Combinatorial Biosynthesis of (+)-Daurichromenic Acid and Its Halogenated Analogue (2017)
  • Author(s): Okada Masahiro、Saito Kai、Wong Chin Piow、Li Chang、Wang Dongmei、Iijima Miu、Taura Futoshi、Kurosaki Fumiya、Awakawa Takayoshi、Abe Ikuro
  • Journal Title: Organic Letters Volume: 19 Issue: 12 Pages: 3183-3186
  • DOI: 10.1021/acs.orglett.7b01288
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 2-Alkylquinolone alkaloid biosynthesis in the medicinal plantEvodia rutaecarpainvolves collaboration of two novel type III polyketide synthases (2017)
  • Author(s): Matsui Takashi、Kodama Takeshi、Mori Takahiro、Tadakoshi Tetsuhiro、Noguchi Hiroshi、Abe Ikuro、Morita Hiroyuki
  • Journal Title: Journal of Biological Chemistry Volume: 292 Issue: 22 Pages: 9117-9135
  • DOI: 10.1074/jbc.m117.778977
  • NAID: 120006559815
  • Peer Reviewed
• [Journal Article] Identification of pyridinium with three indole moieties as an antimicrobial agent (2017)
  • Author(s): Okada, M., Sugita, T., Wong, C. P., Wakimoto, T., Abe, I.
  • Journal Title: J. Nat. Prod., Volume: 80 Issue: 4 Pages: 1205-1209
  • DOI: 10.1021/acs.jnatprod.6b01152
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Posttranslational isoprenylation of tryptophan in bacteria (2017)
  • Author(s): Masahiro Okada, Tomotoshi Sugita, Ikuro Abe
  • Journal Title: Beilstein J. Org. Chem. Volume: 13 Pages: 338-346
  • DOI: 10.3762/bjoc.13.37
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification and Characterization of Daurichromenic Acid Synthase Active in Anti-HIV Biosynthesis (2017)
  • Author(s): Iijima Miu、Munakata Ryosuke、Takahashi Hironobu、Kenmoku Hiromichi、Nakagawa Ryuichi、Kodama Takeshi、Asakawa Yoshinori、Abe Ikuro、Yazaki Kazufumi、Kurosaki Fumiya、Taura Futoshi
  • Journal Title: Plant Physiology Volume: 174 Issue: 4 Pages: 2213-2230
  • DOI: 10.1104/pp.17.00586
  • Peer Reviewed
• [Journal Article] 3,5-Dimethylorsellinic Acid Derived Meroterpenoids from Penicillium chrysogenum MT-12, an Endophytic Fungus Isolated from Huperzia serrata (2017)
  • Author(s): Qi Bowen、Liu Xiao、Mo Ting、Zhu Zhixiang、Li Jun、Wang Juan、Shi Xiaoping、Zeng Kewu、Wang Xiaohui、Tu Pengfei、Abe Ikuro、Shi Shepo
  • Journal Title: Journal of Natural Products Volume: 80 Issue: 10 Pages: 2699-2707
  • DOI: 10.1021/acs.jnatprod.7b00438
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases (2016)
  • Author(s): T. Mori, L. Zhang, T. Awakawa, S. Hoshino, M. Okada, H. Morita, I. Abe
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 10849-10851
  • DOI: 10.1038/ncomms10849
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Structural insight into the enzymatic formation of bacterial stilbene (2016)
  • Author(s): Mori, T., Awakawa, T., Shimomura, K., Saito, Y., Yang, D., Morita, H., Abe, I.
  • Journal Title: Cell Chem. Biol. Volume: 23 Issue: 12 Pages: 1468-1479
  • DOI: 10.1016/j.chembiol.2016.10.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Discovery of key dioxygenases that diverged the paraherquonin and acetoxydehydroaustin pathways in Penicillium brasilianum (2016)
  • Author(s): Matsuda, Y., Iwabuchi,T., Fujimoto, T., Awakawa,T., Nakashima, Y., Mori, T., Zhang, H., Hayashi, F., Abe, I.
  • Journal Title: J. Am. Chem. Soc. Volume: 138 Issue: 38 Pages: 12671-12677
  • DOI: 10.1021/jacs.6b08424
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoids biosynthesis (2016)
  • Author(s): Okada, M., Matsuda, Y., Mitsuhashi, T., Hoshino, S., Mori, T., Nakagawa, K., Quan, Z., Qin, B., Zhang, H., Hayashi, F., Kawaide, H., Abe, I.
  • Journal Title: J. Am. Chem. Soc. Volume: 138 Issue: 31 Pages: 10011-10018
  • DOI: 10.1021/jacs.6b05799
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Astellifadiene, a unique tetracyclic fungal sesterterpene: structure determination by an NMR-coupled crystalline sponge method and elucidation of its biosynthesis (2016)
  • Author(s): Matsuda, Y., Mitsuhashi,T., Lee, S., Hoshino, M., Mori, T., Okada, M., Zhang, H., Hayashi, F., Fujita, M., Abe, I.
  • Journal Title: Angew. Chem. Int. Ed. Volume: 55 Issue: 19 Pages: 5785-5788
  • DOI: 10.1002/anie.201601448
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An unusual chimeric diterpene synthase from Emericella varicolor and its functional conversion into a sesterterpene synthase by domain swapping (2016)
  • Author(s): B. Qin, Y. Matsuda, T. Mori, M. Okada, Z. Quan, T. Mitsuhashi, T. Wakimoto, I. Abe
  • Journal Title: Angew. Chem. Int. Ed. Volume: 55 Issue: 5 Pages: 1658-1661
  • DOI: 10.1002/anie.201509263
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Biosynthesis of fungal meroterpenoids (2016)
  • Author(s): Matsuda, Y., Abe, I.
  • Journal Title: Nat. Prod. Rep. Volume: 33 Issue: 1 Pages: 26-53
  • DOI: 10.1039/c5np00090d
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Calyculin: Nature’s way of making the sponge-derived cytotoxin (2016)
  • Author(s): T. Wakimoto, Y. Egami, I. Abe
  • Journal Title: Nat. Prod. Rep. Volume: 未定 Issue: 6 Pages: 751-760
  • DOI: 10.1039/c5np00123d
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Unusual chemistries in fungal meroterpenoid biosynthesis (2016)
  • Author(s): Matsuda, Y., Awakawa, T., Mori, T., Abe, I.
  • Journal Title: Curr. Opin. Chem. Biol. Volume: 31 Pages: 1-7
  • DOI: 10.1016/j.cbpa.2015.11.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Rational control of polyketide extender units by structure-based engineering of a crotonyl-CoA carboxylase/ reductase in antimycin biosynthesis (2015)
  • Author(s): Zhang, L., Mori, T., Zheng, Q., Awakawa, T., Yan, Y., Liu, W., Abe, I.,
  • Journal Title: Angewandte Chemie International Edition Volume: 54 Issue: 45 Pages: 13462-13465
  • DOI: 10.1002/anie.201506899
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Structural basis for the β-carboline alkaloids production by the microbial homodimeric enzyme McbB (2015)
  • Author(s): T. Mori, S. Hoshino, S. Sahashi, T. Wakimoto, T. Matsui, H. Morita, I. Abe
  • Journal Title: Chem. Biol. Volume: 17 Issue: 7 Pages: 1501-1504
  • DOI: 10.1016/j.chembiol.2015.06.006
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Structural basis for the formation of acylalkylpyrones from two β-ketoacyl units by the fungal type III polyketide synthase CsyB (2015)
  • Author(s): Mori, T., Yang, D., Matsui, T, Hashimoto, M., Morita, H., Fujii, I., Abe, I.
  • Journal Title: J. Biol. Chem. Volume: 290 Issue: 8 Pages: 5214-5225
  • DOI: 10.1074/jbc.m114.626416
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Molecular basis for stellatic acid biosynthesis: a genome mining approach for discovery of sesterterpene synthases (2015)
  • Author(s): Matsuda, Y., Mitsuhashi, T., Quan, Z., Abe, I.
  • Journal Title: Org. Lett. Volume: 17 Issue: 18 Pages: 4644-4647
  • DOI: 10.1021/acs.orglett.5b02404
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase (2015)
  • Author(s): Matsuda, Y., Iwabuchi, T., Wakimoto, T., Awakawa, T., Abe, I.
  • Journal Title: J. Am. Chem. Soc. Volume: 137 Issue: 9 Pages: 3393-3401
  • DOI: 10.1021/jacs.5b00570
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Engineered Biosynthesis of Medicinal Natural Products (2018)
  • Author(s): Ikuro Abe
  • Organizer: 34th International Conference on Natural Products 2018 (ICNP 2018)
  • Int'l Joint Research / Invited
• [Presentation] Unusual Enzyme Reactions in Fungal Meroterpenoid Biosynthesis (2018)
  • Author(s): Ikuro Abe
  • Organizer: 8th CMDD Symposium on Marine Natural Products
  • Int'l Joint Research / Invited
• [Presentation] Unusual Enzyme Reactions in Fungal Meroterpenoid Biosynthesis (2018)
  • Author(s): Ikuro Abe
  • Organizer: The Society for Industrial Microbiology (SIMB), “2nd International Conference on Natural Product Discovery and Development in the Genomic Era”
  • Int'l Joint Research / Invited
• [Presentation] Engineered Biosynthesis of Medicinal Natural Products (2018)
  • Author(s): Ikuro Abe
  • Organizer: 2018 Synthetic Biotechnology Training Course, Beijing
  • Int'l Joint Research / Invited
• [Presentation] Redesigning Complex Natural Products Biosynthesis (2017)
  • Author(s): 阿部郁朗
  • Organizer: PSJ-AAPS Joint Symposium, Creation of Complex Functional Molecules by Rational Redesign of Biosynthetic Machineries
  • Place of Presentation: 仙台国際センター（宮城県・仙台市）
  • Year and Date: 2017-03-26
  • Int'l Joint Research / Invited
• [Presentation] 複雑骨格天然物の生合成マシナリーの解明と再設計 (2017)
  • Author(s): 阿部郁朗
  • Organizer: 日本農芸化学会2017年度京都大会シンポジウム、農芸化学から発信する次世代型天然物化学
  • Place of Presentation: 京都女子大（京都府・京都市）
  • Year and Date: 2017-03-18
  • Invited
• [Presentation] Engineered Biosynthesis of Medicinal Natural Products (2017)
  • Author(s): 阿部郁朗
  • Organizer: The 2nd International Conference on Herbal and Traditional Medicine (HTM2017)
  • Place of Presentation: Bangkok (Thailand)
  • Year and Date: 2017-01-25
  • Int'l Joint Research / Invited
• [Presentation] 薬用天然物の生合成リデザイン (2017)
  • Author(s): 阿部郁朗
  • Organizer: 理研シンポジウム、高磁場・高感度NMR利活用促進のための天然物分野における日中連携シンポジウム2017
  • Int'l Joint Research / Invited
• [Presentation] 放線菌由来生物活性二次代謝産物の生合成研究 (2017)
  • Author(s): 阿部郁朗
  • Organizer: 公益財団法人日本感染症医薬品協会、メディカルサイエンス・セミナー、住木・梅澤記念賞受賞講演
  • Invited
• [Presentation] 複雑骨格薬用天然物の合成生物学 (2017)
  • Author(s): 阿部郁朗
  • Organizer: JST-ACCEL「革新的分子構造解析」公開シンポジウム
  • Invited
• [Presentation] Molecular Basis for the Unusual Ring Reconstruction in Fungal Meroterpenoid Biogenesis (2017)
  • Author(s): Ikuro Abe
  • Organizer: 3rd Sino-Italian Symposium on Bioactive Natural Products & 1st International Forum for Drug Discovery Chemistry
  • Int'l Joint Research / Invited
• [Presentation] Unusual Enzyme Reactions in Fungal Meroterpenoid Biosynthesis (2017)
  • Author(s): Ikuro Abe
  • Organizer: 1st China-Japan Joint Symposium on Natural Product Biosynthesis
  • Int'l Joint Research / Invited
• [Presentation] 薬用天然物の生合成工学に関する研究 (2017)
  • Author(s): 阿部郁朗
  • Organizer: 日本生薬学会 第64回年会、生薬学会賞受賞講演
  • Invited
• [Presentation] Engineered Biosynthesis of Fungal Meroterpenoids (2017)
  • Author(s): Ikuro Abe
  • Organizer: The American Society of Pharmacognosy Annual Meeting
  • Int'l Joint Research / Invited
• [Presentation] Structure-guided Engineered Biosynthesis of Fungal Meroterpenoid (2017)
  • Author(s): Ikuro Abe
  • Organizer: 13th International Meeting on Biosynthesis, Function and Synthetic Biology of Isoprenoids (TERPNET 2017)
  • Int'l Joint Research / Invited
• [Presentation] Enzymes Involved in the Complex Natural Products Biosynthesis (2017)
  • Author(s): Ikuro Abe
  • Organizer: 9th US-Japan Seminar on Natural Product Biosynthesis
  • Int'l Joint Research / Invited
• [Presentation] Biosynthesis of Fungal Meroterpenoids (2016)
  • Author(s): 阿部郁朗
  • Organizer: Czech-Japan Joint Workshop, Innovative Technologies for the Discovery of Natural Products
  • Place of Presentation: Prague (Czech Republic)
  • Year and Date: 2016-11-09
  • Int'l Joint Research / Invited
• [Presentation] Engineered Biosynthesis of Medicinal Natural Products (2016)
  • Author(s): 阿部郁朗
  • Organizer: 2016 Mogan Mountain International Summit on Green Pharmaceuticals
  • Place of Presentation: Hangzhou (China)
  • Year and Date: 2016-11-02
  • Int'l Joint Research / Invited
• [Presentation] Biosynthesis of Fungal Meroterpenoids (2016)
  • Author(s): 阿部郁朗
  • Organizer: 13th International Symposium on the Genetics of Industrial Microorganisms (GIM2016)
  • Place of Presentation: Wuhan (China)
  • Year and Date: 2016-10-18
  • Int'l Joint Research / Invited
• [Presentation] Multifunctional Oxygenases Involved in Complex Natural Products Biosynthesis (2016)
  • Author(s): 阿部郁朗
  • Organizer: Cytochrome P450 Biodiversity & Biotechnology 2016
  • Place of Presentation: Vancouver (Canada)
  • Year and Date: 2016-07-26
  • Int'l Joint Research / Invited
• [Presentation] Multifunctional oxygenases in the biosynthesis of fungal meroterpenoids (2015)
  • Author(s): 阿部郁朗
  • Organizer: Pacifichem 2015
  • Place of Presentation: Hawaii (USA)
  • Year and Date: 2015-12-19
  • Int'l Joint Research / Invited
• [Presentation] Engineered Biosynthesis of Medicinal Natural Products (2015)
  • Author(s): 阿部郁朗
  • Organizer: 14th FAOBMB Congress and 84th Annual Meeting of SBC
  • Place of Presentation: Hyderabad (India)
  • Year and Date: 2015-11-30
  • Int'l Joint Research / Invited
• [Presentation] Engineered Biosynthesis of. Medicinal Natural Products (2015)
  • Author(s): 阿部郁朗
  • Organizer: 7th AASP Conference
  • Place of Presentation: Taipei (Taiwan)
  • Year and Date: 2015-10-30
  • Int'l Joint Research / Invited
• [Presentation] Biosynthesis of Fungal Meroterpenoids (2015)
  • Author(s): 阿部郁朗
  • Organizer: Beilstein Organic Chemistry Symposium
  • Place of Presentation: Pried (Germany)
  • Year and Date: 2015-09-30
  • Int'l Joint Research / Invited
• [Presentation] Engineered Biosynthesis of Medicinal Natural Products (2015)
  • Author(s): 阿部郁朗
  • Organizer: ISPSA2015
  • Place of Presentation: Tokushima (Japan)
  • Year and Date: 2015-08-30
  • Int'l Joint Research / Invited
• [Presentation] Biosynthesis of fungal meroterpenoids (2015)
  • Author(s): 阿部郁朗
  • Organizer: TERPNET 2015
  • Place of Presentation: Vancouver (Canada)
  • Year and Date: 2015-06-03
  • Int'l Joint Research / Invited
• [Remarks] 東京大学大学院薬学系研究科天然物化学教室
  • URL: http://www.f.u-tokyo.ac.jp/~tennen/head.htm