| Budget Amount *help |
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2017: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2016: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2015: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
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| Outline of Final Research Achievements |
Biological tissues change themselves actively in response to force applied to them. To elucidate this mechanism, we need to know 3D stress and strain distributions at cellular level and compare it with proteins produced by each cell. We studied 3D deformation of intramural microscopic structure in the rabbit thoracic aortas, and found that 1) the longitudinal waviness of the elastic lamina diminishes in response to longitudinal stretch and the circumferential waviness decreases in response to pressurization; and 2) decrease in the waviness of collagen fibers in response to stretch is larger in the smooth muscle layer than in the elastic lamina. We also found that actin filaments are less abundant in the cells reside in the area with high waviness of the elastic lamina.
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