| Project/Area Number |
15H02296
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Composite materials/Surface and interface engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
Yogo Toshinobu 名古屋大学, 未来材料・システム研究所, 名誉教授 (00135310)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO Wataru 名古屋大学, 未来材料システム研究所, 准教授 (50273264)
HAYASHI Koichiro 九州大学, 大学院歯学研究院, 准教授 (80580886)
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| Research Collaborator |
HAYASHI Hikaru
YAMADA Shota
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2015: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
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| Keywords | ハイブリッド材料 / 特異形状 / 赤血球状粒子 / 体内動態 / 肝硬変治療 / 特異形状粒子 / ハイブリッド / 発熱特性 / 生体材料 / 磁性 |
|---|
| Outline of Final Research Achievements |
Red-blood-cell like micro particles (RBC-MPs) consisting of cellulose were successfully synthesized. RBC-MPs were intravenously administrated to mice, and their pharmacokinetics were investigated by fluorescence imaging. RBC-MPs avoided the accumulation in the lung and spleen, but accumulated specifically in the liver. Based on the pharmacokinetics of RBC-MPs, the drug to heal fibrosis was incorporated to RBC-MPs, and delivered specifically to the liver. The fibrous was successfully cured without any side effect. In addition, RBC-MPs dispersed with magnetic nanoparticles was molecularly imprinted with cortisol were found to trap cortisol selectively, and to be recoverd by magnet.
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