| Budget Amount *help |
¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2019: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2018: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2017: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
|
|---|
| Outline of Final Research Achievements |
Dendrite patterning through neurite elongation, branching, pruning, self-avoidance and tiling is required for correct circuit formation. Dendritic refinement is known to operate via cytoskeletal modification and membrane-initiated activity-dependent pathways through secretion molecules including Btbd3. In this current study, we revealed that Btbd3 changes its binding partner depends on the activity level. Low activity leads Btdb3 to bind protein which has Rho activity and remove dendrite. High neuronal activity leads to bind to protein which has Rac activity and elongate dendrites. Moreover, dendrites which received very high long-lasting activity makes Btbd3 to dissociate from these proteins and translocates to cytoskeletal fibers to stabilize the structure.
Taken together, we have revealed a molecular mechanism for how dendrite-specific neuronal activity controls precise morphological remodeling during the critical period.
|
