Mechanisms of layer formation in the cerebral cortex

• Project/Area Number: 15H02355
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Keio University
• Principal Investigator: 仲嶋 一範 慶應義塾大学, 医学部(信濃町), 教授 (90280734)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000); Fiscal Year 2018: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000); Fiscal Year 2017: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000); Fiscal Year 2016: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000); Fiscal Year 2015: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
• Keywords: 神経科学 / 発生・分化 / 脳・神経 / 大脳皮質

Outline of Annual Research Achievements

本研究ではこれまでに、Reelinが皮質神経細胞の凝集を誘導できること、また、原子間力顕微鏡を用いた直接的な定量により、確かにReelinによって細胞膜表面のN-カドヘリン依存的な接着力が増強されることを明らかにした。そこで本年度は、発生期の脳においてReelinが産生される辺縁帯直下における細胞構築の詳細を検討した。辺縁帯の直下にはNeuN陰性の比較的未成熟な神経細胞が濃縮した帯状の領域 ‘primitive cortical zone (PCZ)’ が存在することを見出して命名したため、まずは電子顕微鏡を用いてPCZの神経細胞同士がどのように接着しているのかを調べた。その結果、PCZを構築する神経細胞は辺縁帯に対して法線方向に並んでいる傾向があり、互いに細胞体で直接接していることが分かった。この神経細胞集団を‘primitive neuronal cluster’と命名した。このクラスターは概ね法線方向に3~7個 、接線方向に1~2個並んだ細胞で形成され、主にはNeuN陰性の未熟な神経細胞で構成されていた。次に、クラスターを形成する神経細胞の誕生時期を連続子宮内電気穿孔法等を用いて調べた。その結果、早生まれの神経細胞は、遅生まれの神経細胞が取り込まれるにつれてクラスター内で深い位置に移っていくことが分かった。さらに抑制性神経細胞を蛍光ラベルしてクラスターとの関係を調べたところ、抑制性神経細胞も興奮性神経細胞と接してクラスターの中に存在することが分かった。平均6個の神経細胞で形成されるクラスターの中に、抑制性神経細胞は平均0.7個含まれていた。さらに、類似したクラスターはマウスだけではなく、ヒトを含む霊長類でも存在することが分かった。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Inserm, リヨン大学(フランス)
• [Int'l Joint Research] フランシス・クリック研究所(英国)
• [Int'l Joint Research] ジョンズホプキンズ大学医学部/ベイラー医科大学(アメリカ合衆国)
• [Int'l Joint Research] パリ第7大学(フランス)
• [Int'l Joint Research] フランシス・クリック研究所(イギリス)
• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] ジョンズホプキンズ大学医学部(アメリカ合衆国)
• [Journal Article] Drebrin-like (Dbnl) Controls Neuronal Migration via Regulating N-Cadherin Expression in the Developing Cerebral Cortex. (2019)
  • Author(s): Inoue Seika、Hayashi Kanehiro、Fujita Kyota、Tagawa Kazuhiko、Okazawa Hitoshi、Kubo Ken-ichiro、Nakajima Kazunori
  • Journal Title: J Neurosci. Volume: 39 Pages: 678-691
  • DOI: 10.1523/jneurosci.1634-18.2018
  • Peer Reviewed / Open Access
• [Journal Article] Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex. (2019)
  • Author(s): Shin Minkyung、Kitazawa Ayako、Yoshinaga Satoshi、Hayashi Kanehiro、Hirata Yukio、Dehay Colette、Kubo Ken‐ichiro、Nakajima Kazunori
  • Journal Title: J Comp Neurol. Volume: 527 Pages: 1577-1597
  • DOI: 10.1002/cne.24634
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] プレプレート (2018)
  • Author(s): 石井一裕、仲嶋一範
  • Journal Title: 脳科学辞典 Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] ApoER2 controls not only neuronal migration in the intermediate zone, but also termination of migration in the developing cerebral cortex. (2018)
  • Author(s): Yuki Hirota, Ken-ichiro Kubo, Takahiro Fujino, Tokuo T. Yamamoto, and Kazunori Nakajima
  • Journal Title: Cereb. Cortex Volume: in press Pages: 223-235
  • DOI: 10.1093/cercor/bhw369
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Excessive activation of AhR signaling disrupts neuronal migration in the hippocampal CA1 region in the developing mouse (2017)
  • Author(s): Eiki Kimura, Ken-ichiro Kubo, Toshihiro Endo, Kazunori Nakajima, Masaki Kakeyama, and Chiharu Tohyama
  • Journal Title: J. Toxicol. Sci. Volume: 42 Issue: 1 Pages: 25-30
  • DOI: 10.2131/jts.42.25
  • NAID: 130005286645
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reelin transiently promotes N-cadherin?dependent neuronal adhesion during mouse cortical development (2017)
  • Author(s): Yuki Matsunaga, Mariko Noda, Hideki Murakawa, Kanehiro Hayashi, Arata Nagasaka, Seika Inoue, Takaki Miyata, Takashi Miura, Ken-ichiro Kubo, and Kazunori Nakajima
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. Volume: 114 Pages: 2048-2053
  • DOI: 10.1073/pnas.1615215114
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Control of neuronal migration and aggregation by Reelin signaling in the developing cerebral cortex. (2017)
  • Author(s): Yuki Hirota and Kazunori Nakajima
  • Journal Title: Front. Cell Dev. Biol. Volume: 5
  • DOI: 10.3389/fcell.2017.00040
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. (2017)
  • Author(s): Ken-ichiro Kubo, K. Deguchi, T. Nagai, Y. Ito, K. Yoshida, T. Endo, S. Benner, W.Shan, A. Kitazawa, M. Aramaki, K. Ishii, M. Shin, Y. Matsunaga, K. Hayashi, M. Kakeyama, C. Tohyama, K.F. Tanaka, K. Tanaka, S. Takashima, M. Nakayama, M. Itoh, Y. Hirata, B. Antalffy, D.D. Armstrong, K. Yamada, K. Inoue, Kazunori Nakajima
  • Journal Title: JCI Insight Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Editorial: Mechanisms of neuronal migration during corticogenesis. (2016)
  • Author(s): Chiaki Ohtaka-Maruyama, Kazunori Nakajima, Alessandra Pierani, and Nobuaki Maeda
  • Journal Title: Front Neurosci Volume: 10 Pages: 172-172
  • DOI: 10.3389/fnins.2016.00172
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy. (2016)
  • Author(s): Haruka Sudo and Kazunori Nakajima
  • Journal Title: Oncotarget Volume: 7 Pages: 53712-53734
  • DOI: 10.18632/oncotarget.10728
  • Peer Reviewed / Open Access
• [Journal Article] DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia. (2016)
  • Author(s): Minae Niwa, Tyler Cash-Padgett, Ken-Ichiro Kubo, Atsushi Saito, Kazuhiro Ishii, Akiko Sumitomo, Yu Taniguchi, Koko Ishizuka, Hanna Jaaro-Peled, Toshifumi Tomoda, Kazunori Nakajima, Akira Sawa, and Atsushi Kamiya
  • Journal Title: Mol. Psychiatry Volume: 21 Pages: 1488-1489
  • DOI: 10.1038/mp.2016.154
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] ADP rebosylation factor 6 regulates neuronal migration in the developing cerebral cortex thruough FIP2/Arfophilin-1-dependent endosomal trafficking of N-cadherin (2016)
  • Author(s): Yoshinobu Hara, Masahiro Fukaya, Kanehiro Hayashi, Takeshi Kawauchi, Kazunori Nakajima, and Hiroyuki Sakagami
  • Journal Title: eNeuro Volume: 3 Pages: 1-20
  • DOI: 10.1523/eneuro.0148-16.2016
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reelin and neuropsychiatric disorders. (2016)
  • Author(s): Kazuhiro Ishii, Ken-ichiro Kubo, and Kazunori Nakajima
  • Journal Title: Front. Cell. Neurosci. Volume: 10
  • DOI: 10.3389/fncel.2016.00229
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 大脳新皮質の層形成過程におけるリーリンの役割 (2016)
  • Author(s): 仲嶋一範
  • Journal Title: BRAIN and NERVE Volume: 68 Pages: 931-937
  • NAID: 40020933663
• [Journal Article] Propagation of focal imbalance through neuronal circuits. (Author Response) (2016)
  • Author(s): Ken-ichiro Kubo, Kazuhiro Ishii, Masaki Kakeyama, and Kazunori Nakajima
  • Journal Title: J. Neurosci. Volume: 36
  • DOI: 10.1523/jneurosci.4014-15.2016
• [Journal Article] In utero Bisphenol A Exposure Induces Abnormal Neuronal Migration in the Cerebral Cortex of Mice (2016)
  • Author(s): Wenting Ling, Toshihiro Endo, Ken-ichiro Kubo, Masaki Kakeyama, Kazunori Nakajima, and Chiharu Tohyama.
  • Journal Title: Frontiers in Endocrinology Volume: 7 Pages: 1-6
  • DOI: 10.3389/fendo.2016.00007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex. (2016)
  • Author(s): Koji Oishi, Nao Nakagawa, Kashiko Tachikawa, Shinji Sasaki, Michihiko Aramaki, Shinji Hirano, Nobuhiko Yamamoto, Yumiko Yoshimura, Kazunori Nakajima
  • Journal Title: eLife Volume: 5 Pages: 1-26
  • DOI: 10.7554/elife.10907.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mutually repressive interaction between Brn1/2 and Rorb contributes to establishment of neocortical layer 2/3 and layer 4. (2016)
  • Author(s): Koji Oishi, Kazunori Nakajima
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. Volume: 113(12) Pages: 3371-3376
  • DOI: 10.1073/pnas.1515949113
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Proper Level of Cytosolic Disabled-1, Which Is Regulated by Dual Nuclear Translocation Pathways, Is Important for Cortical Neuronal Migration. (2016)
  • Author(s): Honda T and Nakajima K
  • Journal Title: Cerebral Cortex Volume: bhv162 Pages: 1-18
  • DOI: 10.1093/cercor/bhv162
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex. (2016)
  • Author(s): Stephanie Tankou, Kazuhiro Ishii, Christina Elliott, Krishna C. Yalla, Jon P. Day, Keiko Furukori, Ken-ichiro Kubo, Nicholas J. Brandon, Qiyi Tang, Gary Hayward, Kazunori Nakajima, Miles D. Houslay, Atsushi Kamiya, George Baillie, Koko Ishizuka, and Akira Sawa
  • Journal Title: Mol. Neuropsychiatry Volume: 2 Pages: 20-27
  • DOI: 10.1159/000444257
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PDK1?Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex (2016)
  • Author(s): Itoh, Y., Higuchi, M., Oishi, K.,Kishi, Y., Okazaki, T., Sakai, H., Miyata, T., Nakajima, K., Gotoh, Y.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 113(21) Pages: 2955-64
  • DOI: 10.1073/pnas.1516321113
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis (2015)
  • Author(s): Takao Kohno, Takao Honda,Ken-ichiro Kubo, Yoshimi Nakano, Ayaka Tsuchiya, Tatsuro Murakami, Hideyuki Banno, Kazunori Nakajima, and Mitsuharu Hattori
  • Journal Title: J. Neurosci. Volume: 35(11) Pages: 4776-4787
  • DOI: 10.1523/jneurosci.4119-14.2015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cellular dynamics of neuronal migration in the hippocampus (2015)
  • Author(s): Hayashi K, Kubo K, Kitazawa A and Nakajima K
  • Journal Title: Front Neurosci. Volume: in press Pages: 135-135
  • DOI: 10.3389/fnins.2015.00135
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits. (2015)
  • Author(s): Kazuhiro Ishii, Taku Nagai, Yuki Hirota, Mariko Noda, Toshitaka Nabeshima, Kiyofumi Yamada, Ken-ichiro Kubo, and Kazunori Nakajima
  • Journal Title: Neurosci Res. Volume: 印刷中 Pages: 30-36
  • DOI: 10.1016/j.neures.2014.12.013
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Analysis of cardiomyocyte movement in the developing murine heart. (2015)
  • Author(s): Hashimoto H, Yuasa S, Tabata H, Tohyama S, Seki T, Egashira T, Hayashiji N, Hattori F, Kusumoto D, Kunitomi A, Takei M, Kashimura S, Yozu G, Shimojima M, Motoda C, Muraoka N, Nakajima K, Sakaue-Sawano A, Miyawaki A, Fukuda K
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 464 Pages: 1000-1007
  • DOI: 10.1016/j.bbrc.2015.07.036
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon- derived GABAergic neurons in the developing mouse brain. (2015)
  • Author(s): Shigeaki Kanatani, Takao Honda, Michihiko Aramaki, Kanehiro Hayashi, Ken-ichiro Kubo, Mami Ishida, Daisuke H. Tanaka, Takeshi Kawauchi, Katsutoshi Sekine, Sayaka Kusuzawa, Takahiko Kawasaki, Tatsumi Hirata, Hidenori Tabata, Per Uhlen and Kazunori Nakajima
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 112(36)
  • DOI: 10.1073/pnas.1420701112
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits. (2015)
  • Author(s): Kazuhiro Ishii, Ken-ichiro Kubo, Toshihiro Endo, Keitaro Yoshida, Seico Benner, Yukiko Ito, Hidenori Aizawa, Michihiko Aramaki, Akihiro Yamanaka, Kohichi Tanaka, Norio Takata, Kenji Tanaka, Masaru Mimura, Chiahru Tohyama, Masaki Kakeyama, and Kazunori Nakajima
  • Journal Title: J. Neurosci. Volume: 35 Pages: 12432-12445
  • DOI: 10.1523/jneurosci.3648-14.2015
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Developmental origin of abnormal dendritic growth in the mouse brain induced by in utero disruption of arly hydrocarbon receptor signaling (2015)
  • Author(s): Eiki Kimura, Ken-ichiro Kubo, Chieri Matsuyoshi, Seico Benner, Mayuko Hosokawa, Toshihiro Endo, Wenting Ling, Masanobu Kohda, Kazuhito Yokoyama, Kazunori Nakajima, Masaki Kakeyama, and Chiharu Tohyama.
  • Journal Title: Neurotoxicology and Teratology Volume: 52 Pages: 42-50
  • DOI: 10.1016/j.ntt.2015.10.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Transient formation of primitive neuronal clusters at the outermost region of the developing mammalian neocortex (2019)
  • Author(s): Minkyung Shin, Ayako Kitazawa, Satoshi Yoshinaga, Kanehiro Hayashi, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第12回神経発生討論会
• [Presentation] Neuronal migration and layer formation in the developing cerebral neocortex (2019)
  • Author(s): Kazunori Nakajima
  • Organizer: Brain Malformations: A Roadmap for Future Phenotyping and Research
  • Int'l Joint Research / Invited
• [Presentation] 発生中の大脳新皮質において辺縁帯直下に認める比較的未成熟な神経細胞の凝集構造についての知見 (Findings on primitive neuronal clusters formed beneath the marginal zone of the developing mammalian neocortices) (2019)
  • Author(s): 久保健一郎、シン ミンギョン、北澤彩子、吉永怜史、林周宏、仲嶋一範
  • Organizer: 第124回日本解剖学会総会・全国学術集会
• [Presentation] 異所移植による発生期のマウス海馬CA1及び大脳新皮質の移動についての解析 (2019)
  • Author(s): 北澤彩子、シン ミンギョン、林周宏、久保健一郎、仲嶋一範
  • Organizer: 第124回日本解剖学会総会・全国学術集会
• [Presentation] リーリンシグナルによるニューロン移動停止制御機構 (2019)
  • Author(s): 廣田ゆき、仲嶋一範
  • Organizer: 第124回日本解剖学会総会・全国学術集会
• [Presentation] FlashTag technology reveals areal differences in neuronal migration and positioning in the cerebral cortex of developing mice (2019)
  • Author(s): Satoshi Yoshinaga, Minkyun Shin, Ayako Kitazawa, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第124回日本解剖学会総会・全国学術集会
• [Presentation] Control of neuronal layer formation during cerebral cortical development (2018)
  • Author(s): Kazunori Nakajima
  • Organizer: 22nd Biennial Meeting of the International Society for Developmental Neuroscience (ISDN2018), Symposium: “Cell migration and layer formation in the developing cerebral cortex”
  • Int'l Joint Research / Invited
• [Presentation] Haploinsufficiency of dab1 causes upward shift and invasion of superficial-layer neurons into the cortical layer I and splitting of the CA1 pyramidal cell layer (2018)
  • Author(s): Takao Honda and Kazunori Nakajima
  • Organizer: 22nd Biennial Meeting of the International Society for Developmental Neuroscience (ISDN2018)
  • Int'l Joint Research
• [Presentation] Subtype specification of cortical neurons by the extracellular environment (2018)
  • Author(s): Koji Oishi and Kazunori Nakajima
  • Organizer: 22nd Biennial Meeting of the International Society for Developmental Neuroscience (ISDN2018)
  • Int'l Joint Research
• [Presentation] ApoER2 controls not only neuronal migration but also termination of migration in the developing cerebral cortex (2018)
  • Author(s): Yuki Hirota, Ken-ichiro Kubo, Takahiro Fujino, Tokuo T. Yamamoto, and Kazunori Nakajima
  • Organizer: 22nd Biennial Meeting of the International Society for Developmental Neuroscience (ISDN2018)
  • Int'l Joint Research
• [Presentation] Neuronal layer formation during mouse neocortical development (2018)
  • Author(s): Kazunori Nakajima
  • Organizer: Cortical Evolution Conference 2018, Conference Center of the Canary Islands, Las Palmas de Gran Canaria
  • Int'l Joint Research / Invited
• [Presentation] In vivo reprogramming of postmitotic neocortical neurons into different neuronal subtypes (2018)
  • Author(s): Koji Oishi and Kazunori Nakajima
  • Organizer: 第70回日本細胞生物学会・第51回日本発生生物学会合同大会、Symposium: “Developmental Biology in Stem Cell Research and Regenerative Medicine”
  • Int'l Joint Research / Invited
• [Presentation] In vitro and in vivo cell dynamics analysis of iPSC-derived neural crest cells from CHARGE patients harboring CHD7 mutations reveals deficit in delamination, migration and motility of CHARGE syndrome (2018)
  • Author(s): Hironobu Okuno，Francois Renault Mihara, Shigeki Ohta, Kimiko Fukuda, Kenji Kurosawa, Wado Akamatsu, Tsukasa Sanosaka, Jun Kohyama, Kanehiro Hayashi, Kazunori Nakajima, Takao Takahashi, Joanna Wysocka, Kenjiro Kosaki, and Hideyuki Okano
  • Organizer: 第70回日本細胞生物学会・第51回日本発生生物学会合同大会、Symposium: “Developmental Biology in Stem Cell Research and Regenerative Medicine”
  • Int'l Joint Research
• [Presentation] AhR Activation Impairs Neuronal Growth in Mice (2018)
  • Author(s): Eiki Kimura, Ken-ichiro Kubo, Toshihiro Endo, Wenting Ling, Kazunori Nakajima, Masaki Kakeyama, and Chiharu Tohyama
  • Organizer: 68th Lindau Nobel Laureate Meeting, Lindau Inselhalle
  • Int'l Joint Research
• [Presentation] 発生期哺乳類大脳皮質における神経細胞移動は癌細胞の間葉上皮転換と同じ仕組みを持つか？ (2018)
  • Author(s): 林周宏、井上聖香、久保健一郎、仲嶋一範
  • Organizer: 第37回分子病理学研究会はがくれシンポジウム
• [Presentation] CRISPR/Cas9により高感度タグラベルしたDab1の大脳新皮質神経細胞における細胞内分布の解析 (Analysis of subcellular distribution of CRISPR/Cas9-mediated highly sensitive tagged-Dab1 in cerebral neocortical neurons) (2018)
  • Author(s): 本田岳夫、仲嶋一範
  • Organizer: 第41回日本神経科学大会
• [Presentation] リーリンと新規結合分子との結合は、大脳皮質浅層神経細胞の樹状突起発達に必要である（The interaction between Reelin and its novel binding protein is required for dendrite development of cortical upper-layer neurons.) (2018)
  • Author(s): 河野孝夫、牧野誠、石井圭介、廣田ゆき、本田岳夫、仲嶋一範、服部光治
  • Organizer: 第41回日本神経科学大会
• [Presentation] How does Reelin signaling control the termination of neuronal migration? (2018)
  • Author(s): Yuki Hirota and Kazunori Nakajima
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会
• [Presentation] Reelin-DBNL signaling regulates neuronal migration via N-cadherin/α-N-catenin complex in the intermediate zone and multipolar cell accumulation zone of the developing mouse cerebral neocortex (2018)
  • Author(s): Seika Inoue, Kanehiro Hayashi, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会
• [Presentation] Structural view of radial glial cells in the developing mouse neocortex (2018)
  • Author(s): Minkyung Shin, Ayako Kitazawa, Satoshi Yoshinaga, Kanehiro Hayashi, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会
• [Presentation] Astrocyte progenitors require blood vessels for their proper migration and positioning within the cerebral gray matter (2018)
  • Author(s): Hidenori Tabata, Megumi Sasaki, Yutaka Inaguma, Hidenori Ito, Kanehiro Hayashi, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, and Kazunori Nakajima
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会
• [Presentation] Analysis of subcellular distribution of Dab1 in cerebral neocortical excitatory neurons using highly sensitive tagging by genome editing (2018)
  • Author(s): Takao Honda and Kazunori Nakajima
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会
• [Presentation] Optogenetic modulation of neural synchronization in the mouse prefrontal cortex by using in utero electroporation (2018)
  • Author(s): Debabrata Hazra, Satoshi Yoshinaga, Keitaro Yoshida, Kenji F. Tanaka, Kimiko Deguchi, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会
• [Presentation] Subtype specification and reprogramming of cortical neurons in progenitor cells and postmitotic immature neurons (2018)
  • Author(s): Koji Oishi and Kazunori Nakajima
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会、Symposium: “Mechanisms of neuronal production and differentiation in the cerebral cortex”
  • Invited
• [Presentation] Reelin controls N-cadherin-dependent neuronal adhesion by a couple of mechanisms in the developing mouse cortex (2018)
  • Author(s): Kanehiro Hayashi, Nobuhiko Nakao, Seika Inoue, Taiji Adachi, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会
• [Presentation] Reelin function in the developing cerebral neocortex (2018)
  • Author(s): Kazunori Nakajima
  • Organizer: World Federation of the Societies of Biological Psychiatry (WFSBP) Asia Pacific Regional Congress of Biological Psychiatry (WFSBP 2018 KOBE)、Symposium: “Brain Development and Mental Disorder”
  • Int'l Joint Research / Invited
• [Presentation] 神経発達症モデルマウスの作成とその神経回路の解析 (2018)
  • Author(s): 久保健一郎、出口貴美子、石井一裕、井上健、仲嶋一範
  • Organizer: 2018年度生理学研究所研究会 「情動の神経回路機構とその破綻」
  • Invited
• [Presentation] 発生期のマウス大脳新皮質及び海馬CA1における細胞移動様式についての解析 (2018)
  • Author(s): 北澤 彩子、シン ミンギョン、林 周宏、久保 健一郎、仲嶋 一範
  • Organizer: 第27回 海馬と高次脳機能学会
• [Presentation] 大脳皮質発生におけるリーリンシグナルの機能 (2018)
  • Author(s): 廣田ゆき、仲嶋一範
  • Organizer: 2018年度生理学研究所研究会 「神経発達・再生研究会」
  • Invited
• [Presentation] Drebrin-like (Dbnl) controls neuronal migration through regulating N-cadherin expression in the developing mouse cerebral cortex (2018)
  • Author(s): 井上聖香、林周宏、藤田慶大、田川一彦、岡澤均、久保健一郎、仲嶋一範
  • Organizer: 第53回TOKYOニューロサイエンス研究会
• [Presentation] Reelin-Dab1シグナルによる大脳新皮質Layer1形成の制御機構 (2018)
  • Author(s): 本田岳夫、仲嶋一範
  • Organizer: 第53回TOKYOニューロサイエンス研究会
• [Presentation] Optogenetic induction of neural synchronization in the mouse medial prefrontal cortex (2018)
  • Author(s): Debabrata Hazra, Satoshi Yoshinaga, Keitaro Yoshida, Kenji F. Tanaka, Kimiko Deguchi,Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: Society for Neuroscience, Neuroscience 2018 meeting
  • Int'l Joint Research
• [Presentation] Cas9を用いたゲノム編集技術によって高感度タグラベルされたDab1の大脳新皮質神経細胞における細胞内局在の解析 (2018)
  • Author(s): 本田岳夫、仲嶋一範
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] リーリンシグナルによるニューロン移動停止制御機構（How does Reelin signaling control the termination of neuronal migration?） (2018)
  • Author(s): 廣田ゆき、仲嶋一範
  • Organizer: 第41回日本分子生物学会年会、ワークショップ: “多細胞生物の発生における細胞接着・移動”
  • Invited
• [Presentation] マウス大脳皮質発生における、ニューロン移動の領域差の個体発生的解析（Ontogenetic analyses of areal differences in neuronal migration in the cerebral cortex of developing mice） (2018)
  • Author(s): 吉永怜史、シン ミンギョン、北澤彩子、久保健一郎、仲嶋一範
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] 大脳皮質神経細胞の産生調節機構と、その進化 ～マウスとヒトのゲノム配列を用いた機能解析（Regulation of cortical neuron production, and its evolution ~ Functional analyses using mouse and human genome sequences） (2018)
  • Author(s): 田畑秀典、八谷剛史、下田耕治、林周宏、永田浩一、榊原康文、仲嶋一範
  • Organizer: 第41回日本分子生物学会年会、ワークショップ: “脳発生プログラムの複雑化と、その進化”
  • Invited
• [Presentation] 未成熟・成熟大脳皮質ニューロンにおけるサブタイプ転換（Fate Conversion of Subtypes in Immature and Mature Cortical Neurons） (2018)
  • Author(s): 大石康二、仲嶋一範
  • Organizer: 第41回日本分子生物学会年会、ワークショップ: “脳発生プログラムの複雑化と、その進化”
  • Invited
• [Presentation] Drebrin-like (Dbnl) controls neuronal migration via regulating N-cadherin expression in the developing mouse cerebral neocortex (2018)
  • Author(s): Seika Inoue, Kanehiro Hayashi, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 2018 The American Society for Cell Biology (ASCB) Annual Meeting, San Diego Convention Center, San Diego, California (U.S.A.)
  • Int'l Joint Research
• [Presentation] 大脳皮質層構造の形成機構 (2018)
  • Author(s): 仲嶋一範
  • Organizer: 名古屋大学医学部神経解剖学特別講義
  • Invited
• [Presentation] 大脳新皮質の形成機構 (2018)
  • Author(s): 仲嶋一範
  • Organizer: 名古屋大学大学院医学系研究科医学特論
  • Invited
• [Presentation] リーリン受容体ApoER2による大脳皮質ニューロン移動と停止の制御機構 (2017)
  • Author(s): 廣田ゆき、久保健一郎、藤野貴広、山本徳男、仲嶋一範
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学坂本キャンパス（長崎県長崎市）
  • Year and Date: 2017-03-28
• [Presentation] 哺乳類大脳皮質発生における神経細胞移動の領野別検討 (2017)
  • Author(s): 吉永怜史、北澤彩子、シン ミンギョン、久保健一郎、仲嶋一範
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学坂本キャンパス（長崎県長崎市）
  • Year and Date: 2017-03-28
• [Presentation] 超早産児脳障害のモデルマウス脳における組織構築の解析 (2017)
  • Author(s): 久保健一郎、出口貴美子、北澤彩子、石井一裕、シン ミンギョン、高嶋幸男、中山雅弘、伊藤雅之、井上健、仲嶋一範
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学坂本キャンパス（長崎県長崎市）
  • Year and Date: 2017-03-28
• [Presentation] Molecular and morphological analyses of radial glial fibers during mouse neocortical development (発生期のマウス大脳皮質における放射状グリア線維についての分子的・形態的解析) (2017)
  • Author(s): Minkyung Shin, Ayako Kitazawa, Yuki Matsunaga, Kanehiro Hayashi, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第10回神経発生討論会
  • Place of Presentation: 秋保リゾートホテルクレセント（宮城県仙台市）
  • Year and Date: 2017-03-10
• [Presentation] Neuronal layer formation during development of the cerebral cortex” (2017)
  • Author(s): Kazunori Nakajima
  • Organizer: NUS-KEIO JOINT SCIENTIFIC SYMPOSIUM “Frontiers of Translational Medicine -From Cradle to Ageing”
  • Place of Presentation: Singapore
  • Year and Date: 2017-01-10
  • Int'l Joint Research / Invited
• [Presentation] Investigation of the molecular mechanisms underlying Reelin-induced neuronal aggregation in the mouse neocortex (2016)
  • Author(s): Seika Inoue, Kanehiro Hayashi, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 2016 The American Society for Cell Biology (ASCB) Annual Meeting
  • Place of Presentation: San Francisco( U.S.A.)
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] Specification of neuronal layer identity during neocortical development (2016)
  • Author(s): Kazunori Nakajima
  • Organizer: 第39回日本分子生物学会年会、シンポジウム: “神経細胞の誕生と初期神経回路形成の分子メカニズム(Generation of neuronal subtypes and initial steps of circuit formation)
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
  • Invited
• [Presentation] Enhanced expression of Pafah1b causes overmigration of cerebral cortical neurons into the marginal zone (2016)
  • Author(s): Kei-ichi Katayama, Kanehiro Hayashi, Kazushige Sakaguchi, and Kazunori Nakajima
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] 大脳皮質ニューロンのサブタイプ決定におけるポリコーム抑制複合体の役割 (2016)
  • Author(s): 大石康二、仲嶋一範、Francois Guillemot
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] ApoER2 controls neuronal migration in the intermediate zone and termination of migration in the (2016)
  • Author(s): Yuki Hirota, Ken-ichiro Kubo, Takahiro Fujino, Tokuo T. Yamamoto,and Kazunori Nakajima
  • Organizer: The 28th CDB Meeting “Cilia and Centrosomes, Current Advances and Future Directions”
  • Place of Presentation: RIKEN CDB（兵庫県神戸市）
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Morphological analyses of radial glial cells in the developing mouse neocortex (2016)
  • Author(s): Minkyung Shin, Ayako Kitazawa, Yuki Matsunaga, Kanehiro Hayashi, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: Society for Neuroscience, Neuroscience 2014 Meeting
  • Place of Presentation: San Diego(U.S.A.)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Why does cognitive impairment frequently develop later in extremely preterm infants? (2016)
  • Author(s): Ken-ichiro Kubo, Kimiko Deguchi, Taku Nagai, Wei Shan, Ayako Kitazawa, Michihiko Aramaki, Kazuhiro Ishii, Shin Minkyung, Sachio Takashima, Masahiro Nakayama, Masayuki Itoh, Barbara Antalffy, Dawna D. Armstrong, Kiyofumi Yamada, Ken Inoue, and Kazunori Nakajima
  • Organizer: Cell Symposia: Big Questions in Neuroscience
  • Place of Presentation: San Diego(U.S.A.)
  • Year and Date: 2016-11-10
  • Int'l Joint Research
• [Presentation] 大脳皮質ニューロンの分化制御機構 (2016)
  • Author(s): 仲嶋一範
  • Organizer: 日本発生生物学会 秋季シンポジウム2016
  • Place of Presentation: 三島市民文化会館（静岡県三島市）
  • Year and Date: 2016-10-19
• [Presentation] Involvement of Enc1 in neuronal migration and differentiation in the developing neocortex (2016)
  • Author(s): 廣田ゆき、鶴重千加子、味岡逸樹、仲嶋一範
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-09-08
• [Presentation] Analysis of Reelin-Nck signaling in mouse neocortex (2016)
  • Author(s): 林周宏、井上聖香、久保健一郎、仲嶋一範
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-09-08
• [Presentation] Cell-intrinsic and -extrinsic mechanisms that control the specification of neuronal layer identity during neocortical development (2016)
  • Author(s): Kazunori Nakajima
  • Organizer: International Symposium 2016: “Circuit Construction in the Mammalian Brain”
  • Place of Presentation: 大阪大学（大阪府吹田市）
  • Year and Date: 2016-08-08
  • Int'l Joint Research / Invited
• [Presentation] 大脳新皮質においてリーリン分子により誘導される神経細胞凝集を担うシグナル伝達経路の探索 (2016)
  • Author(s): 井上聖香、林周宏、久保健一郎、仲嶋一範
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-08-08
• [Presentation] Cell-extrinsic and -intrinsic mechanisms that control the neuronal layer identity in the developing neocortex（細胞外環境と細胞内機構による大脳新皮質ニューロンの層特異的分化制御） (2016)
  • Author(s): Kazunori Nakajima
  • Organizer: 第39回日本神経科学大会、シンポジウム：“神経発達の分子基盤と精神疾患”
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
  • Invited
• [Presentation] Roles of ApoER2 in neuronal migration and termination of migration in the developing cerebral cortex（大脳皮質形成におけるApoER2による神経細胞移動とその停止制御） (2016)
  • Author(s): Yuki Hirota, Ken-ichiro Kubo, Takahiro Fujino, Tokuo T. Yamamoto, and Kazunori Nakajima
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
• [Presentation] Investigation of the molecular mechanisms that regulate Reelin-induced neuronal aggregation in the mouse neocortex(大脳新皮質においてリーリン分子により引き起こされる神経細胞凝集のシグナル伝達経路の探索) (2016)
  • Author(s): Seika Inoue, Kanehiro Hayashi, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
• [Presentation] Function of the Reelin-Nck signaling pathway during mouse neocortical development (マウス大脳新皮質発生におけるReelin-Nckシグナル経路の役割) (2016)
  • Author(s): Kanehiro Hayashi, Seika Inoue, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
• [Presentation] Experiment and modeling of the Reelin-dependent modification of intercellular adhesion among cells from the developing cerebral cortex (数理モデルと培養実験の併用によるリーリン依存的な大脳皮質細胞接着機構の検討) (2016)
  • Author(s): Yuki Matsunaga, Mariko Noda, Hideki Murakawa, Takashi Miura, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
• [Presentation] Subtype specification in cortical layers is regulated both in neural progenitors and postmitotic neurons(大脳皮質における特定の層への分化は神経系前駆細胞と最終分裂後のニューロンの両段階で制御される) (2016)
  • Author(s): Koji Oishi, Kazunori Nakajima, and Francois Guillemot
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
• [Presentation] Reelin coupled with myelin may play a role in long term maintenance of myelin （リーリンは、ミエリンの長期維持の役割を果たしている） (2016)
  • Author(s): Kimiko Deguchi，Takao Honda, Ken-ichiro Kubo, Kazunori Nakajima, and Ken Inoue
  • Organizer: 第58回日本小児神経学会学術集会
  • Place of Presentation: 京王プラザホテル新宿（東京都新宿区）
  • Year and Date: 2016-06-03
• [Presentation] Reelin coupled with myelin may play a role in long-term maintenance of myelin (2016)
  • Author(s): Kimiko Deguchi, Takao Honda, Ken-ichiro Kubo, Kazunori Nakajima, and Ken Inoue
  • Organizer: 21st Biennial Meeting of the International Society for Developmental Neuroscience (ISDN2016)
  • Place of Presentation: Antibes-Juan les Pins(France)
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] Identity of neocortical layer 4 neurons is specified through correct positioning into the cerebral cortex (2016)
  • Author(s): Koji Oishi, Nao Nakagawa, Kashiko Tachikawa, Shinji Sasaki, Michihiko Aramaki, Shinji Hirano, Nobuhiko Yamamoto, Yumiko Yoshimura, and Kazunori Nakajima (presenter: K. Nakajima)
  • Organizer: 21st Biennial Meeting of the International Society for Developmental Neuroscience (ISDN2016)
  • Place of Presentation: Antibes-Juan les Pins(France)
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] 大脳皮質ニューロンの移動制御機構 (2016)
  • Author(s): 仲嶋一範
  • Organizer: シンポジウム：“形作りのダイナミクスとその制御機構の探索 ～新たな発生原理の解明を目指して”、第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: ビッグパレットふくしま(福島県郡山市)
  • Year and Date: 2016-03-28
  • Invited
• [Presentation] グリア前駆細胞の移動様式と血管との関連 (2016)
  • Author(s): 田畑秀典、佐々木恵、稲熊裕、伊東秀記、竹林浩秀、依馬正次、池中一裕、永田浩一、仲嶋一範
  • Organizer: シンポジウム：“形作りのダイナミクスとその制御機構の探索 ～新たな発生原理の解明を目指して”、第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: ビッグパレットふくしま(福島県郡山市)
  • Year and Date: 2016-03-28
• [Presentation] ApoER2 controls not only neuronal migration but also termination of migration in the developing cerebral cortex (2016)
  • Author(s): 廣田ゆき、久保健一郎、藤野貴広、山本徳男、仲嶋一範
  • Organizer: 第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: ビッグパレットふくしま(福島県郡山市)
  • Year and Date: 2016-03-28
• [Presentation] Analysis of the molecular mechanisms that underlie Reelin-induced neuronal aggregation in the mouse neocortex) (2016)
  • Author(s): Seika Inoue, Kanehiro Hayashi, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第９回神経発生討論会・難治疾患共同研究拠点共同開催学術集会
  • Place of Presentation: 東京医科歯科大学Ｍ＆Ｄタワー鈴木章夫記念講堂(東京都文京区)
  • Year and Date: 2016-03-18
• [Presentation] Analysis of the role of Dab1 nucleo-cytoplasmic transport for migration of excitatory neurons (Dab1の核細胞質間輸送が興奮性神経細胞の移動に果たす役割の解明) (2016)
  • Author(s): Takao Honda and Kazunori Nakajima
  • Organizer: 第９回神経発生討論会・難治疾患共同研究拠点共同開催学術集会
  • Place of Presentation: 東京医科歯科大学Ｍ＆Ｄタワー鈴木章夫記念講堂(東京都文京区)
  • Year and Date: 2016-03-18
• [Presentation] Control of cell migration in the developing cerebral cortex (2016)
  • Author(s): Kazunori Nakajima
  • Organizer: Symposium: “Neuroscience III: Mechanisms of cerebral cortical development" 7th Asia Pacific International Congress of Anatomists
  • Place of Presentation: Singapore
  • Year and Date: 2016-03-17
  • Int'l Joint Research / Invited
• [Presentation] C-terminal region of Reelin is required for development and maintenance of the postnatal cerebral cortex and its functions are regulated by specific proteolysis (2016)
  • Author(s): Takao Kohno, Takao Honda, Ken-ichiro Kubo, Yoshimi Nakano, Ayaka Tsuchiya, Tatsuro Murakami, Hideyuki Banno, Kazunori Nakajima, and Mitsuharu Hattori
  • Organizer: 「神経細胞の多様性と大脳新皮質の構築」第3回国際シンポジウム「Neocortical Organization 3」
  • Place of Presentation: 東京大学小柴ホール(東京都文京区)
  • Year and Date: 2016-02-11
  • Int'l Joint Research
• [Presentation] ApoER2 controls not only neuronal migration but also termination of migration in the developing cerebral cortex (2016)
  • Author(s): Yuki Hirota, Ken-ichiro Kubo, Takahiro Fujino, Tokuo T. Yamamoto, and Kazunori Nakajima
  • Organizer: 「神経細胞の多様性と大脳新皮質の構築」第3回国際シンポジウム「Neocortical Organization 3」
  • Place of Presentation: 東京大学小柴ホール(東京都文京区)
  • Year and Date: 2016-02-11
  • Int'l Joint Research
• [Presentation] Functional screening of the candidate genes involved in the expansion of the subventricular zone in primates using mouse embryos (2016)
  • Author(s): Hidenori Tabata, Tsuyoshi Hachiya, Koh-ichi Nagata, Yasubumi Sakakibara, and Kazunori Nakajima
  • Organizer: 「神経細胞の多様性と大脳新皮質の構築」第3回国際シンポジウム「Neocortical Organization 3」
  • Place of Presentation: 東京大学小柴ホール(東京都文京区)
  • Year and Date: 2016-02-11
  • Int'l Joint Research
• [Presentation] 大脳皮質層構造の形成機構 (2016)
  • Author(s): 仲嶋一範
  • Organizer: 京都大学医学部解剖学特別講義
  • Place of Presentation: 京都大学医学部総合解剖センター（京都府京都市）
  • Invited
• [Presentation] 大脳皮質構築のメカニズム (2016)
  • Author(s): 仲嶋一範
  • Organizer: 京都大学大学院医学研究科セミナー
  • Place of Presentation: 京都大学医学部A棟（京都府京都市）
  • Invited
• [Presentation] 環境因子が大脳皮質の発生・発達過程に与える影響 (2016)
  • Author(s): 仲嶋一範
  • Organizer: 九州大学精神科・特別セミナー
  • Place of Presentation: 九州大学病院ウェストウィング棟（福岡県福岡市）
  • Invited
• [Presentation] 大脳皮質の形成機構 (2016)
  • Author(s): 仲嶋一範
  • Organizer: 九州大学医学部組織学特論
  • Place of Presentation: 九州大学病院キャンパス基礎研究B棟（福岡県福岡市）
  • Invited
• [Presentation] 環境要因としての虚血ストレスが大脳皮質の発達に与える影響（Effects of ischemic stress on cerebral cortical development） (2016)
  • Author(s): 久保健一郎、出口貴美子、井澤栄一、井上健、仲嶋一範
  • Organizer: フォーラム2016：衛生薬学・環境トキシコロジー、シンポジウム：“生体防御・ストレス応答研究の新展開”
  • Place of Presentation: 昭和大学旗の台キャンパス（東京都品川区）
  • Invited
• [Presentation] リーリン分子により形成される神経細胞凝集を制御する分子メカニズム (2016)
  • Author(s): 井上聖香、林周宏、久保健一郎、仲嶋一範
  • Organizer: 第51回慶應ニューロサイエンス研究会
  • Place of Presentation: 慶應義塾大学信濃町キャンパス（東京都新宿区）
• [Presentation] Morphological analyses of radial glial fibers in the developing reeler neocortex (2016)
  • Author(s): Minkyung Shin, Ayako Kitazawa, Yuki Matsunaga, Kanehiro Hayashi, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第51回慶應ニューロサイエンス研究会
  • Place of Presentation: 慶應義塾大学信濃町キャンパス（東京都新宿区）
• [Presentation] 子宮内電気穿孔法を用いたマウス脳内神経細胞における活動制御の試み (2016)
  • Author(s): ハズラ デバブラタ、久保健一郎、仲嶋一範
  • Organizer: 日本解剖学会関東支部 第104回学術集会
  • Place of Presentation: 横浜市立大学八景キャンパス（神奈川県横浜市）
• [Presentation] Experiment and modeling of the Reelin-dependent modification of intercellular adhesion among cerebral cortical cells (2015)
  • Author(s): Yuki Matsunaga, Mariko Noda, Hideki Murakawa, Takashi Miura, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 2015 American Society for Cell Biology Annual Meeting
  • Place of Presentation: San Diego(U.S.A.)
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] マウス発生期脳において移動ニューロンの進む方向と目的地を制御するメカニズム（Molecular mechanism that steers the migrating neurons in the developing mouse brain） (2015)
  • Author(s): 仲嶋 一範
  • Organizer: ワークショップ：“細胞のふるまいの制御から解き明かす大脳皮質形成機構”、第38回日本分子生物学会年会・第88回日本生化学会大会合同大会(BMB2015)
  • Place of Presentation: 神戸ポートアイランド(兵庫県神戸市)
  • Year and Date: 2015-12-01
• [Presentation] 皮質脳室帯由来グリア前駆細胞のダイナミックな移動様式（Dynamic behavior of glia progenitors derived from the cortical ventricular zone） (2015)
  • Author(s): 田畑秀典、佐々木恵、稲熊裕、伊東秀記、竹林浩秀、依馬正次、池中一裕、永田浩一、仲嶋一範
  • Organizer: ワークショップ：“細胞のふるまいの制御から解き明かす大脳皮質形成機構”、第38回日本分子生物学会年会・第88回日本生化学会大会合同大会(BMB2015)
  • Place of Presentation: 神戸ポートアイランド(兵庫県神戸市)
  • Year and Date: 2015-12-01
• [Presentation] Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis (2015)
  • Author(s): Takao Kohno, Takao Honda, Ken-ichiro Kubo, Yoshimi Nakano, Ayaka Tsuchiya, Tatsuro Murakami, Hideyuki Banno, Kazunori Nakajima, and Mitsuharu Hattori
  • Organizer: Society for Neuroscience, Neuroscience 2015 meeting
  • Place of Presentation: Chicago(U.S.A.)
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits (2015)
  • Author(s): Kazuhiro Ishii, Ken-ichiro Kubo, Toshihiro Endo, Keitaro Yoshida, Seico Benner, Yukiko Ito, Hidenori Aizawa, Michihiko Aramaki, Akihiro Yamanaka, Kohichi Tanaka, Norio Takata, Kenji F. Tanaka, Masaru Mimura, Chiharu Tohyama, Masaki Kakeyama, and Kazunori Nakajima
  • Organizer: Society for Neuroscience, Neuroscience 2015 meeting
  • Place of Presentation: Chicago(U.S.A.)
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Application of the in utero electroporation technique to the study of the pathological mechanism of focal heterotopias in the brain (2015)
  • Author(s): Ken-ichiro Kubo, Kazuhiro Ishii, Toshihiro Endo, Keitaro Yoshida, Seico Benner, Yukiko Ito, Hidenori Aizawa, Michihiko Aramaki, Akihiro Yamanaka, Kohichi Tanaka, Norio Takata, Kenji F. Tanaka, Masaru Mimura, Chiharu Tohyama, Masaki Kakeyama, and Kazunori Nakajima
  • Organizer: Cell Symposia: Engineering the Brain -Technologies for Neurobiological Applications
  • Place of Presentation: Chicago(U.S.A.)
  • Year and Date: 2015-10-15
  • Int'l Joint Research
• [Presentation] Interaction between glia and blood vessels during cortical development (2015)
  • Author(s): Hidenori Tabata, Megumi Sasaki, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, and Kazunori Nakajima
  • Organizer: シンポジウム:“The ins and outs of neuro-vascular interactions”、第58回日本神経化学会大会
  • Place of Presentation: 大宮ソニックシティ(埼玉県大宮市)
  • Year and Date: 2015-09-11
  • Invited
• [Presentation] Analyses of the pathological roles of the altered brain cytoarchitectures with ectopic neurons (2015)
  • Author(s): Ken-ichiro Kubo, Kazuhiro Ishii, Toshihiro Endo, Keitaro Yoshida, Seico Benner, Yukiko Ito, Hidenori Aizawa, Michihiko Aramaki, Akihiro Yamanaka, Kohichi Tanaka, Norio Takata, Kenji F. Tanaka, Masaru Mimura, Chiharu Tohyama, Masaki Kakeyama, and Kazunori Nakajima
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮ソニックシティ(埼玉県大宮市)
  • Year and Date: 2015-09-11
• [Presentation] Modeling and analysis and of intercellular adhesion between cells from the developing cerebral cortex (2015)
  • Author(s): Yuki Matsunaga, Mariko Noda, Hideki Murakawa, Takashi Miura, Ken-ichiro Kubo, and Kazunori Nakajima
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮ソニックシティ(埼玉県大宮市)
  • Year and Date: 2015-09-11
• [Presentation] 二つの核移行経路による細胞質Dab1量の適切な調節が大脳皮質ニューロンの移動に重要である（Proper level of cytosolic Disabled-1, which is regulated by dual nuclear translocation pathways, is important for cortical neuronal migration） (2015)
  • Author(s): 本田岳夫、仲嶋一範
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・神戸国際展示場(兵庫県神戸市)
  • Year and Date: 2015-07-28
• [Presentation] Blood vessel-guided cell migration during late cortical plate development (皮質形成後期に見られる血管に沿った細胞移動) (2015)
  • Author(s): Hidenori Tabata, Megumi Sasaki, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, and Kazunori Nakajima
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場・神戸国際展示場(兵庫県神戸市)
  • Year and Date: 2015-07-28
• [Presentation] Blood vessel-guided cell migration in the developing cerebral cortex (発生期大脳皮質における血管に沿った細胞移動の解析) (2015)
  • Author(s): Hidenori Tabata, Megumi Sasaki, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Koh-ichi Nagata, and Kazunori Nakajima
  • Organizer: 第48回日本発生生物学会大会
  • Place of Presentation: つくば国際会議場 (茨城県つくば市)
  • Year and Date: 2015-06-03
• [Presentation] 環境因子が脳の発達や機能に与える影響とその保護 (2015)
  • Author(s): 仲嶋一範
  • Organizer: シンポジウム：“From the bench: Bedsideを見据えた脳発達基礎医科学の新展開”、第57回日本小児神経学会学術集会
  • Place of Presentation: 帝国ホテル大阪 (大阪府大阪市）
  • Year and Date: 2015-05-28
  • Invited
• [Presentation] Cell migration in the developing cerebral cortex (2015)
  • Author(s): Kazunori Nakajima
  • Organizer: EMBO Workshop:“Cortical development in health and disease”
  • Place of Presentation: Rehovot (Israel)
  • Year and Date: 2015-04-26
  • Int'l Joint Research / Invited
• [Presentation] 動く細胞による大脳皮質の形成機構 (2015)
  • Author(s): 仲嶋一範
  • Organizer: 「神経科学序説」講義
  • Place of Presentation: 横浜市立大学大学院生命医科学研究科 (神奈川県横浜市)
  • Invited
• [Presentation] 巨大分泌蛋白質リーリンのC末端領域を介した大脳皮質形成機構 (2015)
  • Author(s): 河野孝夫、本田岳夫、久保健一郎、中野良美、土屋綾香、村上達郎、阪野英幸、仲嶋一範、服部光治
  • Organizer: 第61回日本薬学会東海支部総会・大会
  • Place of Presentation: 名古屋市立大学(愛知県名古屋市)
• [Presentation] 二つの核移行経路による細胞質Dab1量の適切な調節が興奮性神経細胞移動に重要である (2015)
  • Author(s): 本田岳夫、仲嶋一範
  • Organizer: 第50回慶應ニューロサイエンス研究会「システムとしての脳の理解と介入」
  • Place of Presentation: 慶應義塾大学信濃町キャンパス(東京都新宿区)
• [Presentation] 異所性皮質の作成による大脳皮質組織構築変化の病態理解 (2015)
  • Author(s): 久保健一郎、石井一裕、遠藤俊裕、吉田慶太朗、ベナー聖子、伊藤亨子、相澤秀紀、荒巻道彦、山中章弘、田中光一、高田則雄、田中謙二、三村將、遠山千春、掛山正心、仲嶋一範
  • Organizer: 第50回慶應ニューロサイエンス研究会「システムとしての脳の理解と介入」
  • Place of Presentation: 慶應義塾大学信濃町キャンパス(東京都新宿区)
• [Presentation] 発生期のマウス海馬及び大脳新皮質における特異的な細胞移動様式についての解析 (2015)
  • Author(s): 北澤彩子、シン ミンギョン、林周宏、久保健一郎、仲嶋一範
  • Organizer: 日本解剖学会関東支部 第103回学術集会
  • Place of Presentation: 慶應義塾大学日吉キャンパス(神奈川県横浜市)
• [Presentation] Dab1核細胞質間シャトリングの大脳新皮質層形成における役割の解明 (2015)
  • Author(s): 本田岳夫、仲嶋一範
  • Organizer: 日本解剖学会関東支部 第103回学術集会
  • Place of Presentation: 慶應義塾大学日吉キャンパス(神奈川県横浜市)
• [Presentation] 異所性灰白質は離れた脳部位の神経活動に影響を与えて行動の異常を引き起こす (2015)
  • Author(s): 久保健一郎、石井一裕、遠藤俊裕、吉田慶太朗、ベナー聖子、伊藤亨子、相澤秀紀、荒巻道彦、山中章弘、田中光一、高田則雄、田中謙二、三村將、遠山千春、掛山正心、仲嶋一範
  • Organizer: 日本解剖学会関東支部 第103回学術集会
  • Place of Presentation: 慶應義塾大学日吉キャンパス(神奈川県横浜市)
• [Presentation] 大脳皮質神経細胞接着の制御とその数理モデル (2015)
  • Author(s): 松永友貴、野田万理子、村川秀樹、三浦岳、久保健一郎、仲嶋一範
  • Organizer: 日本解剖学会関東支部 第103回学術集会
  • Place of Presentation: 慶應義塾大学日吉キャンパス(神奈川県横浜市)
• [Presentation] 動く細胞たちが脳を作るメカニズム (2015)
  • Author(s): 仲嶋一範
  • Organizer: 独立行政法人科学技術振興機構グローバルサイエンスキャンパス事業 高校生対象講演
  • Place of Presentation: 慶應義塾大学信濃町キャンパス(東京都新宿区)
  • Invited
• [Book] “Cell polarity and initiation of migration” in Comprehensive Developmental Neuroscience: Cellular Migration and Formation of Neuronal Connections (2019)
  • Author(s): Kanehiro Hayashi, Katsutoshi Sekine, Hidenori Tabata, and Kazunori Nakajima
  • Publisher: Academic Press
• [Remarks] マウス発生期大脳皮質において，リーリンはN-カドヘリン依存的な神経細胞接着を一過的に促進する
  • URL: http://www.neurochemistry.jp/index.php?action=pages_view_main&active_action=multidatabase_view_main_detail&content_id=1118&multidatabase_id=2&block_id=15#_15